6E3E

Structure of RORgt in complex with a novel inverse agonist.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0004879	molecular_function	nuclear receptor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 501

Chain	Residue
A	HIS451
A	LEU463
B	HIS451

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site_id	AC2
Number of Residues	4
Details	binding site for residue MPD A 502

Chain	Residue
A	GLU290
A	GLU304
A	TYR308
A	LYS311

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site_id	AC3
Number of Residues	12
Details	binding site for residue HQ7 A 503

Chain	Residue
A	HIS323
A	LEU324
A	VAL361
A	ARG364
A	MET365
A	ALA368
A	PHE377
A	PHE378
A	GLU379
A	HOH603
A	GLN286
A	CYS320

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site_id	AC4
Number of Residues	1
Details	binding site for residue SO4 B 501

Chain	Residue
B	LYS336

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site_id	AC5
Number of Residues	4
Details	binding site for residue MPD B 502

Chain	Residue
B	GLU290
B	GLU304
B	LYS311
B	ARG319

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site_id	AC6
Number of Residues	11
Details	binding site for residue HQ7 B 503

Chain	Residue
B	CYS320
B	HIS323
B	LEU324
B	VAL361
B	MET365
B	ALA368
B	PHE377
B	PHE378
B	GLU379
B	ILE400
B	HOH620

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