6E3B
STRUCTURE OF Siw14 CATALYTIC CORE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016791 | molecular_function | phosphatase activity |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0016791 | molecular_function | phosphatase activity |
| C | 0006470 | biological_process | protein dephosphorylation |
| C | 0016791 | molecular_function | phosphatase activity |
| D | 0006470 | biological_process | protein dephosphorylation |
| D | 0016791 | molecular_function | phosphatase activity |
| E | 0006470 | biological_process | protein dephosphorylation |
| E | 0016791 | molecular_function | phosphatase activity |
| F | 0006470 | biological_process | protein dephosphorylation |
| F | 0016791 | molecular_function | phosphatase activity |
| G | 0006470 | biological_process | protein dephosphorylation |
| G | 0016791 | molecular_function | phosphatase activity |
| H | 0006470 | biological_process | protein dephosphorylation |
| H | 0016791 | molecular_function | phosphatase activity |
| I | 0006470 | biological_process | protein dephosphorylation |
| I | 0016791 | molecular_function | phosphatase activity |
| J | 0006470 | biological_process | protein dephosphorylation |
| J | 0016791 | molecular_function | phosphatase activity |
| K | 0006470 | biological_process | protein dephosphorylation |
| K | 0016791 | molecular_function | phosphatase activity |
| L | 0006470 | biological_process | protein dephosphorylation |
| L | 0016791 | molecular_function | phosphatase activity |
| M | 0006470 | biological_process | protein dephosphorylation |
| M | 0016791 | molecular_function | phosphatase activity |
| N | 0006470 | biological_process | protein dephosphorylation |
| N | 0016791 | molecular_function | phosphatase activity |
| O | 0006470 | biological_process | protein dephosphorylation |
| O | 0016791 | molecular_function | phosphatase activity |
| P | 0006470 | biological_process | protein dephosphorylation |
| P | 0016791 | molecular_function | phosphatase activity |
| Q | 0006470 | biological_process | protein dephosphorylation |
| Q | 0016791 | molecular_function | phosphatase activity |
| R | 0006470 | biological_process | protein dephosphorylation |
| R | 0016791 | molecular_function | phosphatase activity |
| S | 0006470 | biological_process | protein dephosphorylation |
| S | 0016791 | molecular_function | phosphatase activity |
| T | 0006470 | biological_process | protein dephosphorylation |
| T | 0016791 | molecular_function | phosphatase activity |
| V | 0006470 | biological_process | protein dephosphorylation |
| V | 0016791 | molecular_function | phosphatase activity |
| W | 0006470 | biological_process | protein dephosphorylation |
| W | 0016791 | molecular_function | phosphatase activity |
| X | 0006470 | biological_process | protein dephosphorylation |
| X | 0016791 | molecular_function | phosphatase activity |
| Y | 0006470 | biological_process | protein dephosphorylation |
| Y | 0016791 | molecular_function | phosphatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 301 |
| Chain | Residue |
| A | SER214 |
| A | ASN215 |
| A | ARG216 |
| A | GLY217 |
| A | LYS218 |
| A | HIS219 |
| A | ARG220 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 301 |
| Chain | Residue |
| B | ARG216 |
| B | LYS218 |
| B | HIS219 |
| B | ARG220 |
| B | SER214 |
| B | ASN215 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 C 301 |
| Chain | Residue |
| C | SER214 |
| C | ASN215 |
| C | ARG216 |
| C | GLY217 |
| C | LYS218 |
| C | HIS219 |
| C | ARG220 |
| C | HOH407 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 301 |
| Chain | Residue |
| D | SER214 |
| D | ASN215 |
| D | ARG216 |
| D | GLY217 |
| D | LYS218 |
| D | HIS219 |
| D | ARG220 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 E 301 |
| Chain | Residue |
| E | SER214 |
| E | ASN215 |
| E | ARG216 |
| E | GLY217 |
| E | LYS218 |
| E | HIS219 |
| E | ARG220 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 F 301 |
| Chain | Residue |
| F | SER214 |
| F | ASN215 |
| F | ARG216 |
| F | GLY217 |
| F | LYS218 |
| F | HIS219 |
| F | ARG220 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 G 301 |
| Chain | Residue |
| G | SER214 |
| G | ASN215 |
| G | ARG216 |
| G | GLY217 |
| G | LYS218 |
| G | HIS219 |
| G | ARG220 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 H 301 |
| Chain | Residue |
| H | SER214 |
| H | ARG216 |
| H | GLY217 |
| H | HIS219 |
| H | ARG220 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 I 301 |
| Chain | Residue |
| I | SER214 |
| I | ASN215 |
| I | ARG216 |
| I | GLY217 |
| I | LYS218 |
| I | HIS219 |
| I | ARG220 |
| I | HOH402 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 J 301 |
| Chain | Residue |
| J | SER214 |
| J | ASN215 |
| J | ARG216 |
| J | GLY217 |
| J | LYS218 |
| J | HIS219 |
| J | ARG220 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 K 301 |
| Chain | Residue |
| K | SER214 |
| K | ASN215 |
| K | ARG216 |
| K | GLY217 |
| K | LYS218 |
| K | HIS219 |
| K | ARG220 |
| K | HOH404 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 L 301 |
| Chain | Residue |
| L | SER214 |
| L | ASN215 |
| L | ARG216 |
| L | GLY217 |
| L | LYS218 |
| L | HIS219 |
| L | ARG220 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 M 301 |
| Chain | Residue |
| M | SER214 |
| M | ASN215 |
| M | ARG216 |
| M | GLY217 |
| M | LYS218 |
| M | HIS219 |
| M | ARG220 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 N 301 |
| Chain | Residue |
| N | SER214 |
| N | ASN215 |
| N | ARG216 |
| N | GLY217 |
| N | LYS218 |
| N | HIS219 |
| N | ARG220 |
| N | HOH403 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 O 301 |
| Chain | Residue |
| O | SER214 |
| O | ASN215 |
| O | ARG216 |
| O | LYS218 |
| O | HIS219 |
| O | ARG220 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 P 301 |
| Chain | Residue |
| P | SER214 |
| P | ASN215 |
| P | ARG216 |
| P | GLY217 |
| P | LYS218 |
| P | HIS219 |
| P | ARG220 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 Q 301 |
| Chain | Residue |
| Q | SER214 |
| Q | ASN215 |
| Q | ARG216 |
| Q | GLY217 |
| Q | HIS219 |
| Q | ARG220 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 R 301 |
| Chain | Residue |
| R | SER214 |
| R | ASN215 |
| R | ARG216 |
| R | GLY217 |
| R | LYS218 |
| R | HIS219 |
| R | ARG220 |
| site_id | AE1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 S 301 |
| Chain | Residue |
| S | SER214 |
| S | ASN215 |
| S | ARG216 |
| S | GLY217 |
| S | LYS218 |
| S | HIS219 |
| S | ARG220 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 T 301 |
| Chain | Residue |
| T | SER214 |
| T | ARG216 |
| T | GLY217 |
| T | LYS218 |
| T | HIS219 |
| T | ARG220 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 V 301 |
| Chain | Residue |
| V | SER214 |
| V | ASN215 |
| V | ARG216 |
| V | GLY217 |
| V | LYS218 |
| V | HIS219 |
| V | ARG220 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 W 301 |
| Chain | Residue |
| W | SER214 |
| W | ARG216 |
| W | GLY217 |
| W | LYS218 |
| W | HIS219 |
| W | ARG220 |
| W | THR221 |
| W | GLY222 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 X 301 |
| Chain | Residue |
| X | SER214 |
| X | ASN215 |
| X | ARG216 |
| X | GLY217 |
| X | LYS218 |
| X | HIS219 |
| X | ARG220 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 Y 301 |
| Chain | Residue |
| Y | SER214 |
| Y | ASN215 |
| Y | ARG216 |
| Y | GLY217 |
| Y | LYS218 |
| Y | HIS219 |
| Y | ARG220 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000305|PubMed:29540476 |
| Chain | Residue | Details |
| A | SER214 | |
| J | SER214 | |
| K | SER214 | |
| L | SER214 | |
| M | SER214 | |
| N | SER214 | |
| O | SER214 | |
| P | SER214 | |
| Q | SER214 | |
| R | SER214 | |
| S | SER214 | |
| B | SER214 | |
| T | SER214 | |
| V | SER214 | |
| W | SER214 | |
| X | SER214 | |
| Y | SER214 | |
| C | SER214 | |
| D | SER214 | |
| E | SER214 | |
| F | SER214 | |
| G | SER214 | |
| H | SER214 | |
| I | SER214 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 72 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9ZVN4 |
| Chain | Residue | Details |
| A | ASN189 | |
| D | ASN189 | |
| D | ILE190 | |
| D | HIS193 | |
| E | ASN189 | |
| E | ILE190 | |
| E | HIS193 | |
| F | ASN189 | |
| F | ILE190 | |
| F | HIS193 | |
| G | ASN189 | |
| A | ILE190 | |
| G | ILE190 | |
| G | HIS193 | |
| H | ASN189 | |
| H | ILE190 | |
| H | HIS193 | |
| I | ASN189 | |
| I | ILE190 | |
| I | HIS193 | |
| J | ASN189 | |
| J | ILE190 | |
| A | HIS193 | |
| J | HIS193 | |
| K | ASN189 | |
| K | ILE190 | |
| K | HIS193 | |
| L | ASN189 | |
| L | ILE190 | |
| L | HIS193 | |
| M | ASN189 | |
| M | ILE190 | |
| M | HIS193 | |
| B | ASN189 | |
| N | ASN189 | |
| N | ILE190 | |
| N | HIS193 | |
| O | ASN189 | |
| O | ILE190 | |
| O | HIS193 | |
| P | ASN189 | |
| P | ILE190 | |
| P | HIS193 | |
| Q | ASN189 | |
| B | ILE190 | |
| Q | ILE190 | |
| Q | HIS193 | |
| R | ASN189 | |
| R | ILE190 | |
| R | HIS193 | |
| S | ASN189 | |
| S | ILE190 | |
| S | HIS193 | |
| T | ASN189 | |
| T | ILE190 | |
| B | HIS193 | |
| T | HIS193 | |
| V | ASN189 | |
| V | ILE190 | |
| V | HIS193 | |
| W | ASN189 | |
| W | ILE190 | |
| W | HIS193 | |
| X | ASN189 | |
| X | ILE190 | |
| X | HIS193 | |
| C | ASN189 | |
| Y | ASN189 | |
| Y | ILE190 | |
| Y | HIS193 | |
| C | ILE190 | |
| C | HIS193 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | SITE: Transition state stabilizer => ECO:0000305|PubMed:29540476 |
| Chain | Residue | Details |
| A | ARG220 | |
| J | ARG220 | |
| K | ARG220 | |
| L | ARG220 | |
| M | ARG220 | |
| N | ARG220 | |
| O | ARG220 | |
| P | ARG220 | |
| Q | ARG220 | |
| R | ARG220 | |
| S | ARG220 | |
| B | ARG220 | |
| T | ARG220 | |
| V | ARG220 | |
| W | ARG220 | |
| X | ARG220 | |
| Y | ARG220 | |
| C | ARG220 | |
| D | ARG220 | |
| E | ARG220 | |
| F | ARG220 | |
| G | ARG220 | |
| H | ARG220 | |
| I | ARG220 |
