6E2V

MDDEF in complex with MVAPP, ADPBeF3 and magnesium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004163	molecular_function	diphosphomevalonate decarboxylase activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue MG A 401

Chain	Residue
A	SER106
A	DP6403
A	BEF404
A	ADP405
A	HOH527

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site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 402

Chain	Residue
A	HOH566
A	HOH583
A	ALA104
A	DP6403
A	BEF404
A	HOH527

---

site_id	AC3
Number of Residues	19
Details	binding site for residue DP6 A 403

Chain	Residue
A	ALA13
A	TYR17
A	LYS20
A	SER106
A	SER138
A	GLY139
A	SER140
A	ARG143
A	SER191
A	ARG192
A	MET195
A	ASP282
A	MG401
A	MG402
A	BEF404
A	ADP405
A	HOH519
A	HOH527
A	HOH583

---

site_id	AC4
Number of Residues	12
Details	binding site for residue BEF A 404

Chain	Residue
A	GLY102
A	ALA104
A	LYS187
A	SER191
A	ASP282
A	ALA283
A	MG401
A	MG402
A	DP6403
A	ADP405
A	HOH527
A	HOH617

---

site_id	AC5
Number of Residues	25
Details	binding site for residue ADP A 405

Chain	Residue
A	THR42
A	PHE57
A	SER93
A	ASN95
A	ALA100
A	ALA101
A	GLY102
A	LEU103
A	ALA104
A	SER105
A	SER106
A	GLY109
A	LEU110
A	LYS187
A	SER191
A	MG401
A	DP6403
A	BEF404
A	HOH519
A	HOH529
A	HOH541
A	HOH557
A	HOH578
A	HOH587
A	HOH610

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