6E07

Crystal structure of Canton G6PD in complex with structural NADP

Replaces:  5VG5

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005536	molecular_function	D-glucose binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0006629	biological_process	lipid metabolic process
B	0006695	biological_process	cholesterol biosynthetic process
B	0006739	biological_process	NADP+ metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0009051	biological_process	pentose-phosphate shunt, oxidative branch
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0010041	biological_process	response to iron(III) ion
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0019322	biological_process	pentose biosynthetic process
B	0021762	biological_process	substantia nigra development
B	0030246	molecular_function	carbohydrate binding
B	0032094	biological_process	response to food
B	0034451	cellular_component	centriolar satellite
B	0034599	biological_process	cellular response to oxidative stress
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043249	biological_process	erythrocyte maturation
B	0043523	biological_process	regulation of neuron apoptotic process
B	0045471	biological_process	response to ethanol
B	0046390	biological_process	ribose phosphate biosynthetic process
B	0050661	molecular_function	NADP binding
B	0051156	biological_process	glucose 6-phosphate metabolic process
B	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
B	0070062	cellular_component	extracellular exosome
B	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
B	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
C	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005536	molecular_function	D-glucose binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006098	biological_process	pentose-phosphate shunt
C	0006629	biological_process	lipid metabolic process
C	0006695	biological_process	cholesterol biosynthetic process
C	0006739	biological_process	NADP+ metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0009051	biological_process	pentose-phosphate shunt, oxidative branch
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0010041	biological_process	response to iron(III) ion
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0019322	biological_process	pentose biosynthetic process
C	0021762	biological_process	substantia nigra development
C	0030246	molecular_function	carbohydrate binding
C	0032094	biological_process	response to food
C	0034451	cellular_component	centriolar satellite
C	0034599	biological_process	cellular response to oxidative stress
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043249	biological_process	erythrocyte maturation
C	0043523	biological_process	regulation of neuron apoptotic process
C	0045471	biological_process	response to ethanol
C	0046390	biological_process	ribose phosphate biosynthetic process
C	0050661	molecular_function	NADP binding
C	0051156	biological_process	glucose 6-phosphate metabolic process
C	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
C	0070062	cellular_component	extracellular exosome
C	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
C	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
F	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005536	molecular_function	D-glucose binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006098	biological_process	pentose-phosphate shunt
F	0006629	biological_process	lipid metabolic process
F	0006695	biological_process	cholesterol biosynthetic process
F	0006739	biological_process	NADP+ metabolic process
F	0006749	biological_process	glutathione metabolic process
F	0009051	biological_process	pentose-phosphate shunt, oxidative branch
F	0009898	cellular_component	cytoplasmic side of plasma membrane
F	0010041	biological_process	response to iron(III) ion
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
F	0019322	biological_process	pentose biosynthetic process
F	0021762	biological_process	substantia nigra development
F	0030246	molecular_function	carbohydrate binding
F	0032094	biological_process	response to food
F	0034451	cellular_component	centriolar satellite
F	0034599	biological_process	cellular response to oxidative stress
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043249	biological_process	erythrocyte maturation
F	0043523	biological_process	regulation of neuron apoptotic process
F	0045471	biological_process	response to ethanol
F	0046390	biological_process	ribose phosphate biosynthetic process
F	0050661	molecular_function	NADP binding
F	0051156	biological_process	glucose 6-phosphate metabolic process
F	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
F	0070062	cellular_component	extracellular exosome
F	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
F	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
L	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
L	0005515	molecular_function	protein binding
L	0005536	molecular_function	D-glucose binding
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0006006	biological_process	glucose metabolic process
L	0006098	biological_process	pentose-phosphate shunt
L	0006629	biological_process	lipid metabolic process
L	0006695	biological_process	cholesterol biosynthetic process
L	0006739	biological_process	NADP+ metabolic process
L	0006749	biological_process	glutathione metabolic process
L	0009051	biological_process	pentose-phosphate shunt, oxidative branch
L	0009898	cellular_component	cytoplasmic side of plasma membrane
L	0010041	biological_process	response to iron(III) ion
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
L	0019322	biological_process	pentose biosynthetic process
L	0021762	biological_process	substantia nigra development
L	0030246	molecular_function	carbohydrate binding
L	0032094	biological_process	response to food
L	0034451	cellular_component	centriolar satellite
L	0034599	biological_process	cellular response to oxidative stress
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043249	biological_process	erythrocyte maturation
L	0043523	biological_process	regulation of neuron apoptotic process
L	0045471	biological_process	response to ethanol
L	0046390	biological_process	ribose phosphate biosynthetic process
L	0050661	molecular_function	NADP binding
L	0051156	biological_process	glucose 6-phosphate metabolic process
L	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
L	0070062	cellular_component	extracellular exosome
L	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
L	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
N	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
N	0005515	molecular_function	protein binding
N	0005536	molecular_function	D-glucose binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0006006	biological_process	glucose metabolic process
N	0006098	biological_process	pentose-phosphate shunt
N	0006629	biological_process	lipid metabolic process
N	0006695	biological_process	cholesterol biosynthetic process
N	0006739	biological_process	NADP+ metabolic process
N	0006749	biological_process	glutathione metabolic process
N	0009051	biological_process	pentose-phosphate shunt, oxidative branch
N	0009898	cellular_component	cytoplasmic side of plasma membrane
N	0010041	biological_process	response to iron(III) ion
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
N	0019322	biological_process	pentose biosynthetic process
N	0021762	biological_process	substantia nigra development
N	0030246	molecular_function	carbohydrate binding
N	0032094	biological_process	response to food
N	0034451	cellular_component	centriolar satellite
N	0034599	biological_process	cellular response to oxidative stress
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0043249	biological_process	erythrocyte maturation
N	0043523	biological_process	regulation of neuron apoptotic process
N	0045471	biological_process	response to ethanol
N	0046390	biological_process	ribose phosphate biosynthetic process
N	0050661	molecular_function	NADP binding
N	0051156	biological_process	glucose 6-phosphate metabolic process
N	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
N	0070062	cellular_component	extracellular exosome
N	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
N	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
Q	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
Q	0005515	molecular_function	protein binding
Q	0005536	molecular_function	D-glucose binding
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006006	biological_process	glucose metabolic process
Q	0006098	biological_process	pentose-phosphate shunt
Q	0006629	biological_process	lipid metabolic process
Q	0006695	biological_process	cholesterol biosynthetic process
Q	0006739	biological_process	NADP+ metabolic process
Q	0006749	biological_process	glutathione metabolic process
Q	0009051	biological_process	pentose-phosphate shunt, oxidative branch
Q	0009898	cellular_component	cytoplasmic side of plasma membrane
Q	0010041	biological_process	response to iron(III) ion
Q	0016020	cellular_component	membrane
Q	0016491	molecular_function	oxidoreductase activity
Q	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
Q	0019322	biological_process	pentose biosynthetic process
Q	0021762	biological_process	substantia nigra development
Q	0030246	molecular_function	carbohydrate binding
Q	0032094	biological_process	response to food
Q	0034451	cellular_component	centriolar satellite
Q	0034599	biological_process	cellular response to oxidative stress
Q	0042802	molecular_function	identical protein binding
Q	0042803	molecular_function	protein homodimerization activity
Q	0043249	biological_process	erythrocyte maturation
Q	0043523	biological_process	regulation of neuron apoptotic process
Q	0045471	biological_process	response to ethanol
Q	0046390	biological_process	ribose phosphate biosynthetic process
Q	0050661	molecular_function	NADP binding
Q	0051156	biological_process	glucose 6-phosphate metabolic process
Q	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
Q	0070062	cellular_component	extracellular exosome
Q	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
Q	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
T	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
T	0005515	molecular_function	protein binding
T	0005536	molecular_function	D-glucose binding
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0006006	biological_process	glucose metabolic process
T	0006098	biological_process	pentose-phosphate shunt
T	0006629	biological_process	lipid metabolic process
T	0006695	biological_process	cholesterol biosynthetic process
T	0006739	biological_process	NADP+ metabolic process
T	0006749	biological_process	glutathione metabolic process
T	0009051	biological_process	pentose-phosphate shunt, oxidative branch
T	0009898	cellular_component	cytoplasmic side of plasma membrane
T	0010041	biological_process	response to iron(III) ion
T	0016020	cellular_component	membrane
T	0016491	molecular_function	oxidoreductase activity
T	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
T	0019322	biological_process	pentose biosynthetic process
T	0021762	biological_process	substantia nigra development
T	0030246	molecular_function	carbohydrate binding
T	0032094	biological_process	response to food
T	0034451	cellular_component	centriolar satellite
T	0034599	biological_process	cellular response to oxidative stress
T	0042802	molecular_function	identical protein binding
T	0042803	molecular_function	protein homodimerization activity
T	0043249	biological_process	erythrocyte maturation
T	0043523	biological_process	regulation of neuron apoptotic process
T	0045471	biological_process	response to ethanol
T	0046390	biological_process	ribose phosphate biosynthetic process
T	0050661	molecular_function	NADP binding
T	0051156	biological_process	glucose 6-phosphate metabolic process
T	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
T	0070062	cellular_component	extracellular exosome
T	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
T	2000378	biological_process	negative regulation of reactive oxygen species metabolic process
W	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
W	0005515	molecular_function	protein binding
W	0005536	molecular_function	D-glucose binding
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0006006	biological_process	glucose metabolic process
W	0006098	biological_process	pentose-phosphate shunt
W	0006629	biological_process	lipid metabolic process
W	0006695	biological_process	cholesterol biosynthetic process
W	0006739	biological_process	NADP+ metabolic process
W	0006749	biological_process	glutathione metabolic process
W	0009051	biological_process	pentose-phosphate shunt, oxidative branch
W	0009898	cellular_component	cytoplasmic side of plasma membrane
W	0010041	biological_process	response to iron(III) ion
W	0016020	cellular_component	membrane
W	0016491	molecular_function	oxidoreductase activity
W	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
W	0019322	biological_process	pentose biosynthetic process
W	0021762	biological_process	substantia nigra development
W	0030246	molecular_function	carbohydrate binding
W	0032094	biological_process	response to food
W	0034451	cellular_component	centriolar satellite
W	0034599	biological_process	cellular response to oxidative stress
W	0042802	molecular_function	identical protein binding
W	0042803	molecular_function	protein homodimerization activity
W	0043249	biological_process	erythrocyte maturation
W	0043523	biological_process	regulation of neuron apoptotic process
W	0045471	biological_process	response to ethanol
W	0046390	biological_process	ribose phosphate biosynthetic process
W	0050661	molecular_function	NADP binding
W	0051156	biological_process	glucose 6-phosphate metabolic process
W	0061052	biological_process	negative regulation of cell growth involved in cardiac muscle cell development
W	0070062	cellular_component	extracellular exosome
W	1904879	biological_process	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
W	2000378	biological_process	negative regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue NAP L 601

Chain	Residue
L	LYS238
L	ARG487
L	ASP493
L	PHE501
L	TYR503
L	TYR507
L	TRP509
L	HOH718
L	HOH756
L	ARG357
L	LYS366
L	ARG370
L	ARG393
L	TYR401
L	LYS403
L	ASP421
L	THR423

---

site_id	AC2
Number of Residues	4
Details	binding site for residue PO4 L 602

Chain	Residue
L	HIS201
L	TYR202
L	LYS205
L	ARG365

---

site_id	AC3
Number of Residues	3
Details	binding site for residue GOL L 603

Chain	Residue
L	ARG227
L	ASP350
N	ASP375

---

site_id	AC4
Number of Residues	1
Details	binding site for residue GOL L 604

Chain	Residue
L	GLU345

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL L 605

Chain	Residue
L	LYS293
L	CYS294
L	SER296
L	GLU345
L	ARG463
L	HOH733
L	HOH772

---

site_id	AC6
Number of Residues	2
Details	binding site for residue GOL L 606

Chain	Residue
L	ARG498
L	GLY500

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL L 607

Chain	Residue
B	GLU347
L	ARG215
L	PHE221
L	GLY222
L	TRP225
L	ARG348

---

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL L 608

Chain	Residue
L	TRP54
L	ARG57
L	LYS432
L	GLU438

---

site_id	AC9
Number of Residues	2
Details	binding site for residue GOL L 609

Chain	Residue
L	GLN471
L	HOH713

---

site_id	AD1
Number of Residues	19
Details	binding site for residue NAP C 601

Chain	Residue
C	LYS238
C	LYS366
C	ARG370
C	ARG393
C	TYR401
C	LYS403
C	ASP421
C	THR423
C	ARG487
C	ASP493
C	MET496
C	PHE501
C	TYR503
C	TYR507
C	TRP509
C	GOL605
C	HOH706
C	HOH709
C	HOH727

---

site_id	AD2
Number of Residues	6
Details	binding site for residue PO4 C 602

Chain	Residue
C	HIS201
C	TYR202
C	LYS205
C	ARG365
C	GLN395
C	HOH737

---

site_id	AD3
Number of Residues	1
Details	binding site for residue GOL C 603

Chain	Residue
C	ARG498

---

site_id	AD4
Number of Residues	1
Details	binding site for residue GOL C 604

Chain	Residue
C	GLU345

---

site_id	AD5
Number of Residues	8
Details	binding site for residue GOL C 605

Chain	Residue
C	LYS386
C	GLU389
C	LYS403
C	GLU417
C	GLN502
C	TYR503
C	GLU504
C	NAP601

---

site_id	AD6
Number of Residues	2
Details	binding site for residue GOL C 606

Chain	Residue
B	ASP375
C	ARG227

---

site_id	AD7
Number of Residues	16
Details	binding site for residue NAP F 601

Chain	Residue
F	LYS238
F	ARG357
F	LYS366
F	ARG370
F	ARG393
F	TYR401
F	LYS403
F	ASP421
F	THR423
F	ARG487
F	ASP493
F	MET496
F	PHE501
F	TYR503
F	TYR507
F	TRP509

---

site_id	AD8
Number of Residues	4
Details	binding site for residue PO4 F 602

Chain	Residue
F	HIS201
F	TYR202
F	LYS205
F	ARG365

---

site_id	AD9
Number of Residues	4
Details	binding site for residue GOL F 603

Chain	Residue
F	ARG227
F	HOH701
Q	ARG219
T	ASP375

---

site_id	AE1
Number of Residues	3
Details	binding site for residue GOL F 605

Chain	Residue
F	GLU491
F	LEU495
F	ARG498

---

site_id	AE2
Number of Residues	1
Details	binding site for residue GOL F 606

Chain	Residue
F	GLN471

---

site_id	AE3
Number of Residues	2
Details	binding site for residue GOL F 607

Chain	Residue
F	ARG120
F	HIS124

---

site_id	AE4
Number of Residues	15
Details	binding site for residue NAP N 601

Chain	Residue
N	LYS238
N	LYS366
N	ARG370
N	ARG393
N	TYR401
N	LYS403
N	ASP421
N	THR423
N	ARG487
N	ASP493
N	PHE501
N	TYR503
N	TYR507
N	TRP509
N	HOH730

---

site_id	AE5
Number of Residues	3
Details	binding site for residue PO4 N 602

Chain	Residue
N	HIS201
N	LYS205
N	ARG365

---

site_id	AE6
Number of Residues	1
Details	binding site for residue GOL N 603

Chain	Residue
N	GLU345

---

site_id	AE7
Number of Residues	2
Details	binding site for residue GOL N 604

Chain	Residue
N	ARG498
N	VAL499

---

site_id	AE8
Number of Residues	4
Details	binding site for residue GOL N 605

Chain	Residue
L	ASP375
N	ARG227
N	ASP350
N	HOH701

---

site_id	AE9
Number of Residues	7
Details	binding site for residue GOL N 606

Chain	Residue
C	GLU347
N	ARG215
N	PHE216
N	PHE221
N	TRP225
N	ARG348
N	HOH718

---

site_id	AF1
Number of Residues	6
Details	binding site for residue GOL N 607

Chain	Residue
N	ALA231
N	GLY351
N	ARG387
N	VAL499
N	GLY500
N	HOH722

---

site_id	AF2
Number of Residues	6
Details	binding site for residue GOL N 608

Chain	Residue
N	LYS293
N	ILE295
N	SER296
N	GLU345
N	ARG463
N	HOH713

---

site_id	AF3
Number of Residues	17
Details	binding site for residue NAP Q 601

Chain	Residue
Q	LYS238
Q	ARG357
Q	LYS366
Q	ARG370
Q	ARG393
Q	TYR401
Q	LYS403
Q	ASP421
Q	THR423
Q	ARG487
Q	ASP493
Q	MET496
Q	PHE501
Q	TYR503
Q	TYR507
Q	TRP509
Q	HOH716

---

site_id	AF4
Number of Residues	4
Details	binding site for residue PO4 Q 602

Chain	Residue
Q	HIS201
Q	TYR202
Q	LYS205
Q	GLN395

---

site_id	AF5
Number of Residues	3
Details	binding site for residue GOL Q 603

Chain	Residue
Q	ARG227
Q	ASP350
W	ASP375

---

site_id	AF6
Number of Residues	19
Details	binding site for residue NAP T 601

Chain	Residue
T	LYS238
T	ARG357
T	LYS366
T	ARG370
T	ARG393
T	TYR401
T	LYS403
T	ASP421
T	THR423
T	ARG487
T	ASP493
T	MET496
T	PHE501
T	TYR503
T	TYR507
T	TRP509
T	HOH702
T	HOH726
T	HOH730

---

site_id	AF7
Number of Residues	3
Details	binding site for residue PO4 T 602

Chain	Residue
T	HIS201
T	LYS205
T	ARG365

---

site_id	AF8
Number of Residues	2
Details	binding site for residue GOL T 603

Chain	Residue
F	ASP375
T	ARG227

---

site_id	AF9
Number of Residues	3
Details	binding site for residue GOL T 604

Chain	Residue
T	VAL376
T	GLN383
T	CYS385

---

site_id	AG1
Number of Residues	16
Details	binding site for residue NAP W 601

Chain	Residue
W	LYS238
W	LYS366
W	ARG370
W	ARG393
W	TYR401
W	LYS403
W	ASP421
W	THR423
W	ARG487
W	ASP493
W	TYR503
W	TYR507
W	TRP509
W	HOH712
W	HOH715
W	HOH720

---

site_id	AG2
Number of Residues	3
Details	binding site for residue PO4 W 602

Chain	Residue
W	HIS201
W	LYS205
W	ARG365

---

site_id	AG3
Number of Residues	3
Details	binding site for residue GOL W 603

Chain	Residue
W	ARG227
W	HOH701
W	HOH728

---

site_id	AG4
Number of Residues	3
Details	binding site for residue GOL W 604

Chain	Residue
W	TYR343
W	GLU345
W	HOH729

---

site_id	AG5
Number of Residues	17
Details	binding site for residue NAP B 601

Chain	Residue
B	LYS238
B	GLU364
B	LYS366
B	ARG370
B	ARG393
B	TYR401
B	LYS403
B	ASP421
B	THR423
B	ARG487
B	ASP493
B	MET496
B	PHE501
B	TYR503
B	TYR507
B	TRP509
B	HOH701

---

site_id	AG6
Number of Residues	4
Details	binding site for residue PO4 B 602

Chain	Residue
B	HIS201
B	LYS205
B	ARG365
B	GLN395

---

site_id	AG7
Number of Residues	3
Details	binding site for residue GOL B 603

Chain	Residue
B	ARG227
B	ASP350
C	ASP375

---

Functional Information from PROSITE/UniProt

site_id	PS00069
Number of Residues	7
Details	G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE

Chain	Residue	Details
L	ASP200-GLU206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P11411","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	168
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10745013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BH9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BH9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15858258","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BHL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"24769394","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---