6DZS
Mycobacterial homoserine dehydrogenase ThrA in complex with NADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004412 | molecular_function | homoserine dehydrogenase activity |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0009088 | biological_process | L-threonine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004412 | molecular_function | homoserine dehydrogenase activity |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0009088 | biological_process | L-threonine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050661 | molecular_function | NADP binding |
| C | 0004412 | molecular_function | homoserine dehydrogenase activity |
| C | 0006520 | biological_process | amino acid metabolic process |
| C | 0009088 | biological_process | L-threonine biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0050661 | molecular_function | NADP binding |
| D | 0004412 | molecular_function | homoserine dehydrogenase activity |
| D | 0006520 | biological_process | amino acid metabolic process |
| D | 0009088 | biological_process | L-threonine biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue NAP A 500 |
| Chain | Residue |
| A | GLY14 |
| A | LEU81 |
| A | MET82 |
| A | PRO84 |
| A | PRO87 |
| A | ALA105 |
| A | LYS107 |
| A | GLY309 |
| A | THR313 |
| A | HOH608 |
| A | LEU15 |
| A | GLY16 |
| A | ASN17 |
| A | VAL18 |
| A | VAL48 |
| A | ARG49 |
| A | ARG50 |
| A | ARG55 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue NAP B 500 |
| Chain | Residue |
| B | LEU15 |
| B | ASN17 |
| B | VAL18 |
| B | VAL48 |
| B | ARG49 |
| B | ARG50 |
| B | ARG55 |
| B | LEU81 |
| B | MET82 |
| B | PRO84 |
| B | PRO87 |
| B | ALA105 |
| B | ASN106 |
| B | LYS107 |
| B | GLY309 |
| B | THR313 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue NAP C 500 |
| Chain | Residue |
| C | GLY14 |
| C | LEU15 |
| C | GLY16 |
| C | ASN17 |
| C | VAL18 |
| C | VAL48 |
| C | ARG49 |
| C | ARG50 |
| C | ARG55 |
| C | ILE66 |
| C | LEU81 |
| C | MET82 |
| C | ALA105 |
| C | LYS107 |
| C | GLY309 |
| C | THR313 |
| C | HOH601 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | binding site for residue NAP D 500 |
| Chain | Residue |
| D | GLY14 |
| D | LEU15 |
| D | GLY16 |
| D | ASN17 |
| D | VAL18 |
| D | VAL48 |
| D | ARG49 |
| D | ARG50 |
| D | ARG55 |
| D | ILE66 |
| D | LEU81 |
| D | MET82 |
| D | PRO87 |
| D | ALA105 |
| D | LYS107 |
| D | ALA308 |
| D | GLY309 |
| D | THR313 |
Functional Information from PROSITE/UniProt
| site_id | PS01042 |
| Number of Residues | 23 |
| Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AsalGYAea.DPtaDVeGyDaaaK |
| Chain | Residue | Details |
| A | ALA185-LYS207 |
