6DZS

Mycobacterial homoserine dehydrogenase ThrA in complex with NADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004412	molecular_function	homoserine dehydrogenase activity
A	0006520	biological_process	amino acid metabolic process
A	0009086	biological_process	methionine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0050661	molecular_function	NADP binding
B	0000166	molecular_function	nucleotide binding
B	0004412	molecular_function	homoserine dehydrogenase activity
B	0006520	biological_process	amino acid metabolic process
B	0009086	biological_process	methionine biosynthetic process
B	0009088	biological_process	threonine biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0050661	molecular_function	NADP binding
C	0000166	molecular_function	nucleotide binding
C	0004412	molecular_function	homoserine dehydrogenase activity
C	0006520	biological_process	amino acid metabolic process
C	0009086	biological_process	methionine biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0050661	molecular_function	NADP binding
D	0000166	molecular_function	nucleotide binding
D	0004412	molecular_function	homoserine dehydrogenase activity
D	0006520	biological_process	amino acid metabolic process
D	0009086	biological_process	methionine biosynthetic process
D	0009088	biological_process	threonine biosynthetic process
D	0009097	biological_process	isoleucine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue NAP A 500

Chain	Residue
A	GLY14
A	LEU81
A	MET82
A	PRO84
A	PRO87
A	ALA105
A	LYS107
A	GLY309
A	THR313
A	HOH608
A	LEU15
A	GLY16
A	ASN17
A	VAL18
A	VAL48
A	ARG49
A	ARG50
A	ARG55

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site_id	AC2
Number of Residues	16
Details	binding site for residue NAP B 500

Chain	Residue
B	LEU15
B	ASN17
B	VAL18
B	VAL48
B	ARG49
B	ARG50
B	ARG55
B	LEU81
B	MET82
B	PRO84
B	PRO87
B	ALA105
B	ASN106
B	LYS107
B	GLY309
B	THR313

---

site_id	AC3
Number of Residues	17
Details	binding site for residue NAP C 500

Chain	Residue
C	GLY14
C	LEU15
C	GLY16
C	ASN17
C	VAL18
C	VAL48
C	ARG49
C	ARG50
C	ARG55
C	ILE66
C	LEU81
C	MET82
C	ALA105
C	LYS107
C	GLY309
C	THR313
C	HOH601

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site_id	AC4
Number of Residues	18
Details	binding site for residue NAP D 500

Chain	Residue
D	GLY14
D	LEU15
D	GLY16
D	ASN17
D	VAL18
D	VAL48
D	ARG49
D	ARG50
D	ARG55
D	ILE66
D	LEU81
D	MET82
D	PRO87
D	ALA105
D	LYS107
D	ALA308
D	GLY309
D	THR313

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Functional Information from PROSITE/UniProt

site_id	PS01042
Number of Residues	23
Details	HOMOSER_DHGENASE Homoserine dehydrogenase signature. AsalGYAea.DPtaDVeGyDaaaK

Chain	Residue	Details
A	ALA185-LYS207

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