6DZ4
Crystal structure of Salmonella typhimurium Tryptophan Synthase with sodium ion at the metal coordination site and (E)-N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)-L-serine at the beta-site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | tryptophan biosynthetic process |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006568 | biological_process | tryptophan metabolic process |
| A | 0008152 | biological_process | metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 301 |
| Chain | Residue |
| A | HIS92 |
| A | PRO93 |
| A | THR94 |
| A | ILE95 |
| A | HOH592 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | ARG225 |
| B | CL407 |
| B | HOH758 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 303 |
| Chain | Residue |
| A | HOH499 |
| A | HOH549 |
| A | PHE82 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 304 |
| Chain | Residue |
| A | GLU5 |
| A | ILE148 |
| A | ALA149 |
| A | HOH555 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 305 |
| Chain | Residue |
| A | ASP60 |
| A | TYR175 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue DMS A 306 |
| Chain | Residue |
| A | ASN12 |
| A | GLU16 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue KOU B 401 |
| Chain | Residue |
| B | HIS86 |
| B | LYS87 |
| B | THR110 |
| B | GLY111 |
| B | ALA112 |
| B | GLY113 |
| B | GLN114 |
| B | HIS115 |
| B | THR190 |
| B | GLY232 |
| B | GLY233 |
| B | GLY234 |
| B | SER235 |
| B | ASN236 |
| B | ALA302 |
| B | GLY303 |
| B | ASP305 |
| B | GLU350 |
| B | SER377 |
| B | HOH646 |
| B | HOH677 |
| B | HOH681 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 402 |
| Chain | Residue |
| B | THR66 |
| B | THR69 |
| B | THR71 |
| B | HOH693 |
| B | HOH824 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 403 |
| Chain | Residue |
| B | GLY232 |
| B | PHE306 |
| B | SER308 |
| B | HOH584 |
| B | HOH690 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 405 |
| Chain | Residue |
| B | LYS219 |
| B | GLU220 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 406 |
| Chain | Residue |
| B | GLY274 |
| B | DMS411 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 407 |
| Chain | Residue |
| A | VAL224 |
| A | ARG225 |
| A | CL302 |
| B | HOH755 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 409 |
| Chain | Residue |
| A | PRO138 |
| B | LYS283 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 410 |
| Chain | Residue |
| B | GLN42 |
| B | ALA46 |
| B | HOH902 |
| B | HOH939 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue DMS B 411 |
| Chain | Residue |
| B | LEU271 |
| B | ASN317 |
| B | ARG363 |
| B | GLU364 |
| B | CL406 |
| B | HOH527 |
| B | HOH559 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue DMS B 412 |
| Chain | Residue |
| B | SER143 |
| B | PRO144 |
| B | PHE385 |
| B | HIS388 |
| B | HOH596 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 413 |
| Chain | Residue |
| B | ILE262 |
| B | HIS267 |
| B | HIS273 |
| B | HOH615 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue DMS B 414 |
| Chain | Residue |
| B | GLN36 |
| B | LYS37 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue DMS B 415 |
| Chain | Residue |
| B | TYR8 |
| B | GLY10 |
| B | HOH899 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue DMS B 416 |
| Chain | Residue |
| B | THR3 |
| B | LEU4 |
| B | LEU5 |
| B | ASN6 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue DMS B 417 |
| Chain | Residue |
| B | HIS357 |
| B | GLU364 |
| B | HOH501 |
| B | HOH621 |
| B | HOH879 |
| B | HOH954 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. LELGvPFSDPLADG |
| Chain | Residue | Details |
| A | LEU48-GLY61 |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LlHgGAHKtNqvLgQ |
| Chain | Residue | Details |
| B | LEU80-GLN94 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine |
| Chain | Residue | Details |
| B | LYS87 | |
| A | ASP60 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 383 |
| Chain | Residue | Details |
| B | LYS87 | electron pair acceptor, electron pair donor, nucleofuge, nucleophile, proton acceptor, proton donor |
| B | GLU109 | |
| B | SER377 | hydrogen bond donor |
