Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DVY

Cryo-EM structure of mouse TRPV3 in complex with 2-Aminoethoxydiphenyl borate (2-APB)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005262	molecular_function	calcium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005886	cellular_component	plasma membrane
A	0005929	cellular_component	cilium
A	0006811	biological_process	monoatomic ion transport
A	0007015	biological_process	actin filament organization
A	0007231	biological_process	osmosensory signaling pathway
A	0009266	biological_process	response to temperature stimulus
A	0016020	cellular_component	membrane
A	0035725	biological_process	sodium ion transmembrane transport
A	0042636	biological_process	negative regulation of hair cycle
A	0042802	molecular_function	identical protein binding
A	0043235	cellular_component	receptor complex
A	0090280	biological_process	positive regulation of calcium ion import
A	0098703	biological_process	calcium ion import across plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005261	molecular_function	monoatomic cation channel activity
B	0005262	molecular_function	calcium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005886	cellular_component	plasma membrane
B	0005929	cellular_component	cilium
B	0006811	biological_process	monoatomic ion transport
B	0007015	biological_process	actin filament organization
B	0007231	biological_process	osmosensory signaling pathway
B	0009266	biological_process	response to temperature stimulus
B	0016020	cellular_component	membrane
B	0035725	biological_process	sodium ion transmembrane transport
B	0042636	biological_process	negative regulation of hair cycle
B	0042802	molecular_function	identical protein binding
B	0043235	cellular_component	receptor complex
B	0090280	biological_process	positive regulation of calcium ion import
B	0098703	biological_process	calcium ion import across plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005261	molecular_function	monoatomic cation channel activity
C	0005262	molecular_function	calcium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005886	cellular_component	plasma membrane
C	0005929	cellular_component	cilium
C	0006811	biological_process	monoatomic ion transport
C	0007015	biological_process	actin filament organization
C	0007231	biological_process	osmosensory signaling pathway
C	0009266	biological_process	response to temperature stimulus
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0042636	biological_process	negative regulation of hair cycle
C	0042802	molecular_function	identical protein binding
C	0043235	cellular_component	receptor complex
C	0090280	biological_process	positive regulation of calcium ion import
C	0098703	biological_process	calcium ion import across plasma membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0005261	molecular_function	monoatomic cation channel activity
D	0005262	molecular_function	calcium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005886	cellular_component	plasma membrane
D	0005929	cellular_component	cilium
D	0006811	biological_process	monoatomic ion transport
D	0007015	biological_process	actin filament organization
D	0007231	biological_process	osmosensory signaling pathway
D	0009266	biological_process	response to temperature stimulus
D	0016020	cellular_component	membrane
D	0035725	biological_process	sodium ion transmembrane transport
D	0042636	biological_process	negative regulation of hair cycle
D	0042802	molecular_function	identical protein binding
D	0043235	cellular_component	receptor complex
D	0090280	biological_process	positive regulation of calcium ion import
D	0098703	biological_process	calcium ion import across plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FZ4 A 801

Chain	Residue
A	LEU420
A	HIS426
A	HIS430
A	ARG693
A	ARG696

site_id	AC2
Number of Residues	6
Details	binding site for residue FZ4 A 802

Chain	Residue
A	TYR565
A	MET706
A	SER444
A	CYS496
A	GLU501
A	PHE526

site_id	AC3
Number of Residues	5
Details	binding site for residue FZ4 B 801

Chain	Residue
B	LEU420
B	HIS426
B	HIS430
B	ARG693
B	ARG696

site_id	AC4
Number of Residues	6
Details	binding site for residue FZ4 B 802

Chain	Residue
B	SER444
B	CYS496
B	GLU501
B	PHE526
B	TYR565
B	MET706

site_id	AC5
Number of Residues	5
Details	binding site for residue FZ4 C 801

Chain	Residue
C	LEU420
C	HIS426
C	HIS430
C	ARG693
C	ARG696

site_id	AC6
Number of Residues	7
Details	binding site for residue FZ4 C 802

Chain	Residue
C	MET440
C	SER444
C	CYS496
C	GLU501
C	PHE526
C	TYR565
C	MET706

site_id	AC7
Number of Residues	5
Details	binding site for residue FZ4 D 801

Chain	Residue
D	LEU420
D	HIS426
D	HIS430
D	ARG693
D	ARG696

site_id	AC8
Number of Residues	6
Details	binding site for residue FZ4 D 802

Chain	Residue
D	SER444
D	CYS496
D	GLU501
D	PHE526
D	TYR565
D	MET706

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	140
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	48
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	100
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	124
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	112
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	116
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	120
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	128
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	88
Details	Repeat: {"description":"ANK 6","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	88
Details	Repeat: {"description":"ANK 7","evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8NET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)