Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DVI

Wild-type Lactate Monooxygenase from Mycobacterium smegmatis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0010181	molecular_function	FMN binding
A	0016491	molecular_function	oxidoreductase activity
A	0050040	molecular_function	lactate 2-monooxygenase activity
B	0004497	molecular_function	monooxygenase activity
B	0010181	molecular_function	FMN binding
B	0016491	molecular_function	oxidoreductase activity
B	0050040	molecular_function	lactate 2-monooxygenase activity
C	0004497	molecular_function	monooxygenase activity
C	0010181	molecular_function	FMN binding
C	0016491	molecular_function	oxidoreductase activity
C	0050040	molecular_function	lactate 2-monooxygenase activity
D	0004497	molecular_function	monooxygenase activity
D	0010181	molecular_function	FMN binding
D	0016491	molecular_function	oxidoreductase activity
D	0050040	molecular_function	lactate 2-monooxygenase activity
E	0004497	molecular_function	monooxygenase activity
E	0010181	molecular_function	FMN binding
E	0016491	molecular_function	oxidoreductase activity
E	0050040	molecular_function	lactate 2-monooxygenase activity
F	0004497	molecular_function	monooxygenase activity
F	0010181	molecular_function	FMN binding
F	0016491	molecular_function	oxidoreductase activity
F	0050040	molecular_function	lactate 2-monooxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue FMN A 401

Chain	Residue
A	ALA96
A	SER288
A	HIS290
A	GLY291
A	ARG293
A	ASP320
A	SER321
A	GLY322
A	ARG324
A	ARG344
A	SO4403
A	PRO97
A	HOH566
A	HOH644
A	HOH648
A	ILE98
A	GLY99
A	SER128
A	GLN150
A	TYR152
A	THR178
A	LYS266

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 402

Chain	Residue
A	HIS53
A	ARG56
A	LYS63
A	HOH618
A	HOH766

site_id	AC3
Number of Residues	10
Details	binding site for residue SO4 A 403

Chain	Residue
A	TYR44
A	TYR152
A	PHE184
A	ARG187
A	HIS290
A	ARG293
A	FMN401
A	HOH507
A	HOH557
A	HOH729

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 A 404

Chain	Residue
A	ARG70
A	HIS270
A	ASP387
A	ARG390
A	HOH672
A	HOH788
B	ASP272

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 405

Chain	Residue
A	GLN116
A	HIS141
A	HOH541

site_id	AC6
Number of Residues	23
Details	binding site for residue FMN B 401

Chain	Residue
B	ALA96
B	PRO97
B	ILE98
B	GLY99
B	SER128
B	GLN150
B	TYR152
B	THR178
B	LYS266
B	SER288
B	HIS290
B	GLY291
B	ARG293
B	ASP320
B	SER321
B	GLY322
B	ARG324
B	GLY343
B	ARG344
B	SO4403
B	HOH572
B	HOH580
B	HOH599

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 B 402

Chain	Residue
B	HIS53
B	ARG56
B	LYS63
B	HOH636
B	HOH662
B	HOH663
B	HOH690

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 B 403

Chain	Residue
B	TYR44
B	TYR152
B	ARG187
B	HIS290
B	ARG293
B	FMN401

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 B 404

Chain	Residue
A	LYS310
B	LYS310
B	HOH524
B	HOH525
B	HOH670
B	HOH683

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 B 405

Chain	Residue
B	GLN116
B	HIS141
B	HOH532

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 B 406

Chain	Residue
A	ASP272
B	HIS270
B	ASP387
B	HOH501
B	HOH645

site_id	AD3
Number of Residues	21
Details	binding site for residue FMN C 401

Chain	Residue
C	ILE98
C	GLY99
C	SER128
C	GLN150
C	TYR152
C	THR178
C	LYS266
C	SER288
C	HIS290
C	GLY291
C	ARG293
C	ASP320
C	SER321
C	GLY322
C	ARG324
C	ARG344
C	SO4402
C	HOH1434
C	HOH1494
C	ALA96
C	PRO97

site_id	AD4
Number of Residues	7
Details	binding site for residue SO4 C 402

Chain	Residue
C	TYR44
C	TYR152
C	ARG187
C	HIS290
C	ARG293
C	GLN294
C	FMN401

site_id	AD5
Number of Residues	5
Details	binding site for residue SO4 C 403

Chain	Residue
C	HIS53
C	ARG56
C	LYS63
C	HOH1492
C	HOH1570

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 C 404

Chain	Residue
C	GLN116
C	HIS141
C	HOH1507

site_id	AD7
Number of Residues	4
Details	binding site for residue SO4 C 405

Chain	Residue
C	HIS270
C	ASP387
C	ARG390
C	HOH1401

site_id	AD8
Number of Residues	24
Details	binding site for residue FMN D 401

Chain	Residue
D	ALA96
D	PRO97
D	ILE98
D	GLY99
D	SER128
D	GLN150
D	TYR152
D	THR178
D	LYS266
D	TYR286
D	SER288
D	HIS290
D	GLY291
D	ARG293
D	ASP320
D	SER321
D	GLY322
D	ILE323
D	ARG324
D	GLY343
D	ARG344
D	SO4402
D	HOH521
D	HOH524

site_id	AD9
Number of Residues	7
Details	binding site for residue SO4 D 402

Chain	Residue
D	TYR44
D	TYR152
D	ARG187
D	HIS290
D	ARG293
D	FMN401
D	HOH508

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 D 403

Chain	Residue
D	HIS53
D	ARG56
D	GLU60
D	LYS63

site_id	AE2
Number of Residues	21
Details	binding site for residue FMN E 401

Chain	Residue
E	VAL45
E	PRO97
E	ILE98
E	GLY99
E	VAL100
E	SER128
E	GLN150
E	TYR152
E	THR178
E	LYS266
E	HIS290
E	GLY291
E	ARG293
E	ASP320
E	SER321
E	GLY322
E	ILE323
E	ARG324
E	GLY343
E	ARG344
E	SO4403

site_id	AE3
Number of Residues	3
Details	binding site for residue SO4 E 402

Chain	Residue
E	HIS53
E	ARG56
E	LYS63

site_id	AE4
Number of Residues	6
Details	binding site for residue SO4 E 403

Chain	Residue
E	TYR44
E	TYR152
E	ARG187
E	HIS290
E	ARG293
E	FMN401

site_id	AE5
Number of Residues	20
Details	binding site for residue FMN F 401

Chain	Residue
F	TYR44
F	PRO97
F	ILE98
F	GLY99
F	SER128
F	GLN150
F	TYR152
F	THR178
F	LYS266
F	SER288
F	HIS290
F	GLY291
F	ARG293
F	ASP320
F	SER321
F	GLY322
F	ARG324
F	GLY343
F	ARG344
F	SO4402

site_id	AE6
Number of Residues	6
Details	binding site for residue SO4 F 402

Chain	Residue
F	TYR44
F	TYR152
F	ARG187
F	HIS290
F	ARG293
F	FMN401

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 F 403

Chain	Residue
F	HIS53
F	ARG56
F	LYS63

Functional Information from PROSITE/UniProt

site_id	PS00557
Number of Residues	7
Details	FMN_HYDROXY_ACID_DH_1 FMN-dependent alpha-hydroxy acid dehydrogenases active site. SNHGGRQ

Chain	Residue	Details
A	SER288-GLN294

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000255\|PROSITE-ProRule:PRU00683

Chain	Residue	Details
A	HIS290
B	HIS290
C	HIS290
D	HIS290
E	HIS290
F	HIS290

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00683

Chain	Residue	Details
B	ARG187
B	ARG293
C	TYR44
C	TYR152
C	ARG187
C	ARG293
D	TYR44
D	TYR152
D	ARG187
D	ARG293
E	TYR44
E	TYR152
E	ARG187
E	ARG293
F	TYR44
F	TYR152
F	ARG187
F	ARG293
A	TYR44
A	TYR152
A	ARG187
A	ARG293
B	TYR44
B	TYR152

site_id	SWS_FT_FI3
Number of Residues	42
Details	BINDING: BINDING => ECO:0000269\|PubMed:30207005, ECO:0007744\|PDB:6DVI

Chain	Residue	Details
D	THR178
D	LYS266
D	ASP320
D	ARG344
E	PRO97
E	SER128
E	GLN150
E	THR178
E	LYS266
E	ASP320
E	ARG344
F	PRO97
F	SER128
F	GLN150
F	THR178
F	LYS266
F	ASP320
F	ARG344
D	PRO97
D	SER128
D	GLN150
A	PRO97
A	SER128
A	GLN150
A	THR178
A	LYS266
A	ASP320
A	ARG344
B	PRO97
B	SER128
B	GLN150
B	THR178
B	LYS266
B	ASP320
B	ARG344
C	PRO97
C	SER128
C	GLN150
C	THR178
C	LYS266
C	ASP320
C	ARG344

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)