6DV5

Oligomeric complex of a Hsp27 24-mer at 3.6 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000502	cellular_component	proteasome complex
A	0001533	cellular_component	cornified envelope
A	0001932	biological_process	regulation of protein phosphorylation
A	0003723	molecular_function	RNA binding
A	0005080	molecular_function	protein kinase C binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006446	biological_process	regulation of translational initiation
A	0006457	biological_process	protein folding
A	0006986	biological_process	response to unfolded protein
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0009408	biological_process	response to heat
A	0009615	biological_process	response to virus
A	0010506	biological_process	regulation of autophagy
A	0019901	molecular_function	protein kinase binding
A	0030018	cellular_component	Z disc
A	0032731	biological_process	positive regulation of interleukin-1 beta production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0035556	biological_process	intracellular signal transduction
A	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
A	0042026	biological_process	protein refolding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043066	biological_process	negative regulation of apoptotic process
A	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
A	0043130	molecular_function	ubiquitin binding
A	0043292	cellular_component	contractile muscle fiber
A	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
A	0044183	molecular_function	protein folding chaperone
A	0045766	biological_process	positive regulation of angiogenesis
A	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
A	0051082	molecular_function	unfolded protein binding
A	0060729	biological_process	intestinal epithelial structure maintenance
A	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
A	0070062	cellular_component	extracellular exosome
A	0070527	biological_process	platelet aggregation
A	0090038	biological_process	negative regulation of protein kinase C signaling
A	0099641	biological_process	anterograde axonal protein transport
A	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A	1904115	cellular_component	axon cytoplasm
A	2001028	biological_process	positive regulation of endothelial cell chemotaxis
A	2001234	biological_process	negative regulation of apoptotic signaling pathway
B	0000502	cellular_component	proteasome complex
B	0001533	cellular_component	cornified envelope
B	0001932	biological_process	regulation of protein phosphorylation
B	0003723	molecular_function	RNA binding
B	0005080	molecular_function	protein kinase C binding
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006446	biological_process	regulation of translational initiation
B	0006457	biological_process	protein folding
B	0006986	biological_process	response to unfolded protein
B	0008426	molecular_function	protein kinase C inhibitor activity
B	0009408	biological_process	response to heat
B	0009615	biological_process	response to virus
B	0010506	biological_process	regulation of autophagy
B	0019901	molecular_function	protein kinase binding
B	0030018	cellular_component	Z disc
B	0032731	biological_process	positive regulation of interleukin-1 beta production
B	0032760	biological_process	positive regulation of tumor necrosis factor production
B	0035556	biological_process	intracellular signal transduction
B	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
B	0042026	biological_process	protein refolding
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043066	biological_process	negative regulation of apoptotic process
B	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
B	0043130	molecular_function	ubiquitin binding
B	0043292	cellular_component	contractile muscle fiber
B	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
B	0044183	molecular_function	protein folding chaperone
B	0045766	biological_process	positive regulation of angiogenesis
B	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
B	0051082	molecular_function	unfolded protein binding
B	0060729	biological_process	intestinal epithelial structure maintenance
B	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
B	0070062	cellular_component	extracellular exosome
B	0070527	biological_process	platelet aggregation
B	0090038	biological_process	negative regulation of protein kinase C signaling
B	0099641	biological_process	anterograde axonal protein transport
B	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B	1904115	cellular_component	axon cytoplasm
B	2001028	biological_process	positive regulation of endothelial cell chemotaxis
B	2001234	biological_process	negative regulation of apoptotic signaling pathway
C	0000502	cellular_component	proteasome complex
C	0001533	cellular_component	cornified envelope
C	0001932	biological_process	regulation of protein phosphorylation
C	0003723	molecular_function	RNA binding
C	0005080	molecular_function	protein kinase C binding
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006446	biological_process	regulation of translational initiation
C	0006457	biological_process	protein folding
C	0006986	biological_process	response to unfolded protein
C	0008426	molecular_function	protein kinase C inhibitor activity
C	0009408	biological_process	response to heat
C	0009615	biological_process	response to virus
C	0010506	biological_process	regulation of autophagy
C	0019901	molecular_function	protein kinase binding
C	0030018	cellular_component	Z disc
C	0032731	biological_process	positive regulation of interleukin-1 beta production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0035556	biological_process	intracellular signal transduction
C	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
C	0042026	biological_process	protein refolding
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043066	biological_process	negative regulation of apoptotic process
C	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
C	0043130	molecular_function	ubiquitin binding
C	0043292	cellular_component	contractile muscle fiber
C	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
C	0044183	molecular_function	protein folding chaperone
C	0045766	biological_process	positive regulation of angiogenesis
C	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
C	0051082	molecular_function	unfolded protein binding
C	0060729	biological_process	intestinal epithelial structure maintenance
C	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
C	0070062	cellular_component	extracellular exosome
C	0070527	biological_process	platelet aggregation
C	0090038	biological_process	negative regulation of protein kinase C signaling
C	0099641	biological_process	anterograde axonal protein transport
C	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C	1904115	cellular_component	axon cytoplasm
C	2001028	biological_process	positive regulation of endothelial cell chemotaxis
C	2001234	biological_process	negative regulation of apoptotic signaling pathway
D	0000502	cellular_component	proteasome complex
D	0001533	cellular_component	cornified envelope
D	0001932	biological_process	regulation of protein phosphorylation
D	0003723	molecular_function	RNA binding
D	0005080	molecular_function	protein kinase C binding
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006446	biological_process	regulation of translational initiation
D	0006457	biological_process	protein folding
D	0006986	biological_process	response to unfolded protein
D	0008426	molecular_function	protein kinase C inhibitor activity
D	0009408	biological_process	response to heat
D	0009615	biological_process	response to virus
D	0010506	biological_process	regulation of autophagy
D	0019901	molecular_function	protein kinase binding
D	0030018	cellular_component	Z disc
D	0032731	biological_process	positive regulation of interleukin-1 beta production
D	0032760	biological_process	positive regulation of tumor necrosis factor production
D	0035556	biological_process	intracellular signal transduction
D	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
D	0042026	biological_process	protein refolding
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043066	biological_process	negative regulation of apoptotic process
D	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
D	0043130	molecular_function	ubiquitin binding
D	0043292	cellular_component	contractile muscle fiber
D	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
D	0044183	molecular_function	protein folding chaperone
D	0045766	biological_process	positive regulation of angiogenesis
D	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
D	0051082	molecular_function	unfolded protein binding
D	0060729	biological_process	intestinal epithelial structure maintenance
D	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
D	0070062	cellular_component	extracellular exosome
D	0070527	biological_process	platelet aggregation
D	0090038	biological_process	negative regulation of protein kinase C signaling
D	0099641	biological_process	anterograde axonal protein transport
D	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D	1904115	cellular_component	axon cytoplasm
D	2001028	biological_process	positive regulation of endothelial cell chemotaxis
D	2001234	biological_process	negative regulation of apoptotic signaling pathway
E	0000502	cellular_component	proteasome complex
E	0001533	cellular_component	cornified envelope
E	0001932	biological_process	regulation of protein phosphorylation
E	0003723	molecular_function	RNA binding
E	0005080	molecular_function	protein kinase C binding
E	0005515	molecular_function	protein binding
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005886	cellular_component	plasma membrane
E	0005925	cellular_component	focal adhesion
E	0006446	biological_process	regulation of translational initiation
E	0006457	biological_process	protein folding
E	0006986	biological_process	response to unfolded protein
E	0008426	molecular_function	protein kinase C inhibitor activity
E	0009408	biological_process	response to heat
E	0009615	biological_process	response to virus
E	0010506	biological_process	regulation of autophagy
E	0019901	molecular_function	protein kinase binding
E	0030018	cellular_component	Z disc
E	0032731	biological_process	positive regulation of interleukin-1 beta production
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0035556	biological_process	intracellular signal transduction
E	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
E	0042026	biological_process	protein refolding
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043066	biological_process	negative regulation of apoptotic process
E	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
E	0043130	molecular_function	ubiquitin binding
E	0043292	cellular_component	contractile muscle fiber
E	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
E	0044183	molecular_function	protein folding chaperone
E	0045766	biological_process	positive regulation of angiogenesis
E	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
E	0051082	molecular_function	unfolded protein binding
E	0060729	biological_process	intestinal epithelial structure maintenance
E	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
E	0070062	cellular_component	extracellular exosome
E	0070527	biological_process	platelet aggregation
E	0090038	biological_process	negative regulation of protein kinase C signaling
E	0099641	biological_process	anterograde axonal protein transport
E	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E	1904115	cellular_component	axon cytoplasm
E	2001028	biological_process	positive regulation of endothelial cell chemotaxis
E	2001234	biological_process	negative regulation of apoptotic signaling pathway
F	0000502	cellular_component	proteasome complex
F	0001533	cellular_component	cornified envelope
F	0001932	biological_process	regulation of protein phosphorylation
F	0003723	molecular_function	RNA binding
F	0005080	molecular_function	protein kinase C binding
F	0005515	molecular_function	protein binding
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005886	cellular_component	plasma membrane
F	0005925	cellular_component	focal adhesion
F	0006446	biological_process	regulation of translational initiation
F	0006457	biological_process	protein folding
F	0006986	biological_process	response to unfolded protein
F	0008426	molecular_function	protein kinase C inhibitor activity
F	0009408	biological_process	response to heat
F	0009615	biological_process	response to virus
F	0010506	biological_process	regulation of autophagy
F	0019901	molecular_function	protein kinase binding
F	0030018	cellular_component	Z disc
F	0032731	biological_process	positive regulation of interleukin-1 beta production
F	0032760	biological_process	positive regulation of tumor necrosis factor production
F	0035556	biological_process	intracellular signal transduction
F	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
F	0042026	biological_process	protein refolding
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043066	biological_process	negative regulation of apoptotic process
F	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
F	0043130	molecular_function	ubiquitin binding
F	0043292	cellular_component	contractile muscle fiber
F	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
F	0044183	molecular_function	protein folding chaperone
F	0045766	biological_process	positive regulation of angiogenesis
F	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
F	0051082	molecular_function	unfolded protein binding
F	0060729	biological_process	intestinal epithelial structure maintenance
F	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
F	0070062	cellular_component	extracellular exosome
F	0070527	biological_process	platelet aggregation
F	0090038	biological_process	negative regulation of protein kinase C signaling
F	0099641	biological_process	anterograde axonal protein transport
F	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F	1904115	cellular_component	axon cytoplasm
F	2001028	biological_process	positive regulation of endothelial cell chemotaxis
F	2001234	biological_process	negative regulation of apoptotic signaling pathway
G	0000502	cellular_component	proteasome complex
G	0001533	cellular_component	cornified envelope
G	0001932	biological_process	regulation of protein phosphorylation
G	0003723	molecular_function	RNA binding
G	0005080	molecular_function	protein kinase C binding
G	0005515	molecular_function	protein binding
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006446	biological_process	regulation of translational initiation
G	0006457	biological_process	protein folding
G	0006986	biological_process	response to unfolded protein
G	0008426	molecular_function	protein kinase C inhibitor activity
G	0009408	biological_process	response to heat
G	0009615	biological_process	response to virus
G	0010506	biological_process	regulation of autophagy
G	0019901	molecular_function	protein kinase binding
G	0030018	cellular_component	Z disc
G	0032731	biological_process	positive regulation of interleukin-1 beta production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0035556	biological_process	intracellular signal transduction
G	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
G	0042026	biological_process	protein refolding
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043066	biological_process	negative regulation of apoptotic process
G	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
G	0043130	molecular_function	ubiquitin binding
G	0043292	cellular_component	contractile muscle fiber
G	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
G	0044183	molecular_function	protein folding chaperone
G	0045766	biological_process	positive regulation of angiogenesis
G	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
G	0051082	molecular_function	unfolded protein binding
G	0060729	biological_process	intestinal epithelial structure maintenance
G	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
G	0070062	cellular_component	extracellular exosome
G	0070527	biological_process	platelet aggregation
G	0090038	biological_process	negative regulation of protein kinase C signaling
G	0099641	biological_process	anterograde axonal protein transport
G	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G	1904115	cellular_component	axon cytoplasm
G	2001028	biological_process	positive regulation of endothelial cell chemotaxis
G	2001234	biological_process	negative regulation of apoptotic signaling pathway
H	0000502	cellular_component	proteasome complex
H	0001533	cellular_component	cornified envelope
H	0001932	biological_process	regulation of protein phosphorylation
H	0003723	molecular_function	RNA binding
H	0005080	molecular_function	protein kinase C binding
H	0005515	molecular_function	protein binding
H	0005615	cellular_component	extracellular space
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005886	cellular_component	plasma membrane
H	0005925	cellular_component	focal adhesion
H	0006446	biological_process	regulation of translational initiation
H	0006457	biological_process	protein folding
H	0006986	biological_process	response to unfolded protein
H	0008426	molecular_function	protein kinase C inhibitor activity
H	0009408	biological_process	response to heat
H	0009615	biological_process	response to virus
H	0010506	biological_process	regulation of autophagy
H	0019901	molecular_function	protein kinase binding
H	0030018	cellular_component	Z disc
H	0032731	biological_process	positive regulation of interleukin-1 beta production
H	0032760	biological_process	positive regulation of tumor necrosis factor production
H	0035556	biological_process	intracellular signal transduction
H	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
H	0042026	biological_process	protein refolding
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043066	biological_process	negative regulation of apoptotic process
H	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
H	0043130	molecular_function	ubiquitin binding
H	0043292	cellular_component	contractile muscle fiber
H	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
H	0044183	molecular_function	protein folding chaperone
H	0045766	biological_process	positive regulation of angiogenesis
H	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
H	0051082	molecular_function	unfolded protein binding
H	0060729	biological_process	intestinal epithelial structure maintenance
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0070062	cellular_component	extracellular exosome
H	0070527	biological_process	platelet aggregation
H	0090038	biological_process	negative regulation of protein kinase C signaling
H	0099641	biological_process	anterograde axonal protein transport
H	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
H	1904115	cellular_component	axon cytoplasm
H	2001028	biological_process	positive regulation of endothelial cell chemotaxis
H	2001234	biological_process	negative regulation of apoptotic signaling pathway
I	0000502	cellular_component	proteasome complex
I	0001533	cellular_component	cornified envelope
I	0001932	biological_process	regulation of protein phosphorylation
I	0003723	molecular_function	RNA binding
I	0005080	molecular_function	protein kinase C binding
I	0005515	molecular_function	protein binding
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005819	cellular_component	spindle
I	0005829	cellular_component	cytosol
I	0005856	cellular_component	cytoskeleton
I	0005886	cellular_component	plasma membrane
I	0005925	cellular_component	focal adhesion
I	0006446	biological_process	regulation of translational initiation
I	0006457	biological_process	protein folding
I	0006986	biological_process	response to unfolded protein
I	0008426	molecular_function	protein kinase C inhibitor activity
I	0009408	biological_process	response to heat
I	0009615	biological_process	response to virus
I	0010506	biological_process	regulation of autophagy
I	0019901	molecular_function	protein kinase binding
I	0030018	cellular_component	Z disc
I	0032731	biological_process	positive regulation of interleukin-1 beta production
I	0032760	biological_process	positive regulation of tumor necrosis factor production
I	0035556	biological_process	intracellular signal transduction
I	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
I	0042026	biological_process	protein refolding
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0043066	biological_process	negative regulation of apoptotic process
I	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
I	0043130	molecular_function	ubiquitin binding
I	0043292	cellular_component	contractile muscle fiber
I	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
I	0044183	molecular_function	protein folding chaperone
I	0045766	biological_process	positive regulation of angiogenesis
I	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
I	0051082	molecular_function	unfolded protein binding
I	0060729	biological_process	intestinal epithelial structure maintenance
I	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
I	0070062	cellular_component	extracellular exosome
I	0070527	biological_process	platelet aggregation
I	0090038	biological_process	negative regulation of protein kinase C signaling
I	0099641	biological_process	anterograde axonal protein transport
I	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
I	1904115	cellular_component	axon cytoplasm
I	2001028	biological_process	positive regulation of endothelial cell chemotaxis
I	2001234	biological_process	negative regulation of apoptotic signaling pathway
J	0000502	cellular_component	proteasome complex
J	0001533	cellular_component	cornified envelope
J	0001932	biological_process	regulation of protein phosphorylation
J	0003723	molecular_function	RNA binding
J	0005080	molecular_function	protein kinase C binding
J	0005515	molecular_function	protein binding
J	0005615	cellular_component	extracellular space
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005819	cellular_component	spindle
J	0005829	cellular_component	cytosol
J	0005856	cellular_component	cytoskeleton
J	0005886	cellular_component	plasma membrane
J	0005925	cellular_component	focal adhesion
J	0006446	biological_process	regulation of translational initiation
J	0006457	biological_process	protein folding
J	0006986	biological_process	response to unfolded protein
J	0008426	molecular_function	protein kinase C inhibitor activity
J	0009408	biological_process	response to heat
J	0009615	biological_process	response to virus
J	0010506	biological_process	regulation of autophagy
J	0019901	molecular_function	protein kinase binding
J	0030018	cellular_component	Z disc
J	0032731	biological_process	positive regulation of interleukin-1 beta production
J	0032760	biological_process	positive regulation of tumor necrosis factor production
J	0035556	biological_process	intracellular signal transduction
J	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
J	0042026	biological_process	protein refolding
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0043066	biological_process	negative regulation of apoptotic process
J	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
J	0043130	molecular_function	ubiquitin binding
J	0043292	cellular_component	contractile muscle fiber
J	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
J	0044183	molecular_function	protein folding chaperone
J	0045766	biological_process	positive regulation of angiogenesis
J	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
J	0051082	molecular_function	unfolded protein binding
J	0060729	biological_process	intestinal epithelial structure maintenance
J	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
J	0070062	cellular_component	extracellular exosome
J	0070527	biological_process	platelet aggregation
J	0090038	biological_process	negative regulation of protein kinase C signaling
J	0099641	biological_process	anterograde axonal protein transport
J	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
J	1904115	cellular_component	axon cytoplasm
J	2001028	biological_process	positive regulation of endothelial cell chemotaxis
J	2001234	biological_process	negative regulation of apoptotic signaling pathway
K	0000502	cellular_component	proteasome complex
K	0001533	cellular_component	cornified envelope
K	0001932	biological_process	regulation of protein phosphorylation
K	0003723	molecular_function	RNA binding
K	0005080	molecular_function	protein kinase C binding
K	0005515	molecular_function	protein binding
K	0005615	cellular_component	extracellular space
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005819	cellular_component	spindle
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0005886	cellular_component	plasma membrane
K	0005925	cellular_component	focal adhesion
K	0006446	biological_process	regulation of translational initiation
K	0006457	biological_process	protein folding
K	0006986	biological_process	response to unfolded protein
K	0008426	molecular_function	protein kinase C inhibitor activity
K	0009408	biological_process	response to heat
K	0009615	biological_process	response to virus
K	0010506	biological_process	regulation of autophagy
K	0019901	molecular_function	protein kinase binding
K	0030018	cellular_component	Z disc
K	0032731	biological_process	positive regulation of interleukin-1 beta production
K	0032760	biological_process	positive regulation of tumor necrosis factor production
K	0035556	biological_process	intracellular signal transduction
K	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
K	0042026	biological_process	protein refolding
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0043066	biological_process	negative regulation of apoptotic process
K	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
K	0043130	molecular_function	ubiquitin binding
K	0043292	cellular_component	contractile muscle fiber
K	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
K	0044183	molecular_function	protein folding chaperone
K	0045766	biological_process	positive regulation of angiogenesis
K	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
K	0051082	molecular_function	unfolded protein binding
K	0060729	biological_process	intestinal epithelial structure maintenance
K	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
K	0070062	cellular_component	extracellular exosome
K	0070527	biological_process	platelet aggregation
K	0090038	biological_process	negative regulation of protein kinase C signaling
K	0099641	biological_process	anterograde axonal protein transport
K	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
K	1904115	cellular_component	axon cytoplasm
K	2001028	biological_process	positive regulation of endothelial cell chemotaxis
K	2001234	biological_process	negative regulation of apoptotic signaling pathway
L	0000502	cellular_component	proteasome complex
L	0001533	cellular_component	cornified envelope
L	0001932	biological_process	regulation of protein phosphorylation
L	0003723	molecular_function	RNA binding
L	0005080	molecular_function	protein kinase C binding
L	0005515	molecular_function	protein binding
L	0005615	cellular_component	extracellular space
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005819	cellular_component	spindle
L	0005829	cellular_component	cytosol
L	0005856	cellular_component	cytoskeleton
L	0005886	cellular_component	plasma membrane
L	0005925	cellular_component	focal adhesion
L	0006446	biological_process	regulation of translational initiation
L	0006457	biological_process	protein folding
L	0006986	biological_process	response to unfolded protein
L	0008426	molecular_function	protein kinase C inhibitor activity
L	0009408	biological_process	response to heat
L	0009615	biological_process	response to virus
L	0010506	biological_process	regulation of autophagy
L	0019901	molecular_function	protein kinase binding
L	0030018	cellular_component	Z disc
L	0032731	biological_process	positive regulation of interleukin-1 beta production
L	0032760	biological_process	positive regulation of tumor necrosis factor production
L	0035556	biological_process	intracellular signal transduction
L	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
L	0042026	biological_process	protein refolding
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0043066	biological_process	negative regulation of apoptotic process
L	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
L	0043130	molecular_function	ubiquitin binding
L	0043292	cellular_component	contractile muscle fiber
L	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
L	0044183	molecular_function	protein folding chaperone
L	0045766	biological_process	positive regulation of angiogenesis
L	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
L	0051082	molecular_function	unfolded protein binding
L	0060729	biological_process	intestinal epithelial structure maintenance
L	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
L	0070062	cellular_component	extracellular exosome
L	0070527	biological_process	platelet aggregation
L	0090038	biological_process	negative regulation of protein kinase C signaling
L	0099641	biological_process	anterograde axonal protein transport
L	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
L	1904115	cellular_component	axon cytoplasm
L	2001028	biological_process	positive regulation of endothelial cell chemotaxis
L	2001234	biological_process	negative regulation of apoptotic signaling pathway
M	0000502	cellular_component	proteasome complex
M	0001533	cellular_component	cornified envelope
M	0001932	biological_process	regulation of protein phosphorylation
M	0003723	molecular_function	RNA binding
M	0005080	molecular_function	protein kinase C binding
M	0005515	molecular_function	protein binding
M	0005615	cellular_component	extracellular space
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0005819	cellular_component	spindle
M	0005829	cellular_component	cytosol
M	0005856	cellular_component	cytoskeleton
M	0005886	cellular_component	plasma membrane
M	0005925	cellular_component	focal adhesion
M	0006446	biological_process	regulation of translational initiation
M	0006457	biological_process	protein folding
M	0006986	biological_process	response to unfolded protein
M	0008426	molecular_function	protein kinase C inhibitor activity
M	0009408	biological_process	response to heat
M	0009615	biological_process	response to virus
M	0010506	biological_process	regulation of autophagy
M	0019901	molecular_function	protein kinase binding
M	0030018	cellular_component	Z disc
M	0032731	biological_process	positive regulation of interleukin-1 beta production
M	0032760	biological_process	positive regulation of tumor necrosis factor production
M	0035556	biological_process	intracellular signal transduction
M	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
M	0042026	biological_process	protein refolding
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0043066	biological_process	negative regulation of apoptotic process
M	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
M	0043130	molecular_function	ubiquitin binding
M	0043292	cellular_component	contractile muscle fiber
M	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
M	0044183	molecular_function	protein folding chaperone
M	0045766	biological_process	positive regulation of angiogenesis
M	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
M	0051082	molecular_function	unfolded protein binding
M	0060729	biological_process	intestinal epithelial structure maintenance
M	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
M	0070062	cellular_component	extracellular exosome
M	0070527	biological_process	platelet aggregation
M	0090038	biological_process	negative regulation of protein kinase C signaling
M	0099641	biological_process	anterograde axonal protein transport
M	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
M	1904115	cellular_component	axon cytoplasm
M	2001028	biological_process	positive regulation of endothelial cell chemotaxis
M	2001234	biological_process	negative regulation of apoptotic signaling pathway
N	0000502	cellular_component	proteasome complex
N	0001533	cellular_component	cornified envelope
N	0001932	biological_process	regulation of protein phosphorylation
N	0003723	molecular_function	RNA binding
N	0005080	molecular_function	protein kinase C binding
N	0005515	molecular_function	protein binding
N	0005615	cellular_component	extracellular space
N	0005634	cellular_component	nucleus
N	0005737	cellular_component	cytoplasm
N	0005819	cellular_component	spindle
N	0005829	cellular_component	cytosol
N	0005856	cellular_component	cytoskeleton
N	0005886	cellular_component	plasma membrane
N	0005925	cellular_component	focal adhesion
N	0006446	biological_process	regulation of translational initiation
N	0006457	biological_process	protein folding
N	0006986	biological_process	response to unfolded protein
N	0008426	molecular_function	protein kinase C inhibitor activity
N	0009408	biological_process	response to heat
N	0009615	biological_process	response to virus
N	0010506	biological_process	regulation of autophagy
N	0019901	molecular_function	protein kinase binding
N	0030018	cellular_component	Z disc
N	0032731	biological_process	positive regulation of interleukin-1 beta production
N	0032760	biological_process	positive regulation of tumor necrosis factor production
N	0035556	biological_process	intracellular signal transduction
N	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
N	0042026	biological_process	protein refolding
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0043066	biological_process	negative regulation of apoptotic process
N	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
N	0043130	molecular_function	ubiquitin binding
N	0043292	cellular_component	contractile muscle fiber
N	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
N	0044183	molecular_function	protein folding chaperone
N	0045766	biological_process	positive regulation of angiogenesis
N	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
N	0051082	molecular_function	unfolded protein binding
N	0060729	biological_process	intestinal epithelial structure maintenance
N	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
N	0070062	cellular_component	extracellular exosome
N	0070527	biological_process	platelet aggregation
N	0090038	biological_process	negative regulation of protein kinase C signaling
N	0099641	biological_process	anterograde axonal protein transport
N	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
N	1904115	cellular_component	axon cytoplasm
N	2001028	biological_process	positive regulation of endothelial cell chemotaxis
N	2001234	biological_process	negative regulation of apoptotic signaling pathway
O	0000502	cellular_component	proteasome complex
O	0001533	cellular_component	cornified envelope
O	0001932	biological_process	regulation of protein phosphorylation
O	0003723	molecular_function	RNA binding
O	0005080	molecular_function	protein kinase C binding
O	0005515	molecular_function	protein binding
O	0005615	cellular_component	extracellular space
O	0005634	cellular_component	nucleus
O	0005737	cellular_component	cytoplasm
O	0005819	cellular_component	spindle
O	0005829	cellular_component	cytosol
O	0005856	cellular_component	cytoskeleton
O	0005886	cellular_component	plasma membrane
O	0005925	cellular_component	focal adhesion
O	0006446	biological_process	regulation of translational initiation
O	0006457	biological_process	protein folding
O	0006986	biological_process	response to unfolded protein
O	0008426	molecular_function	protein kinase C inhibitor activity
O	0009408	biological_process	response to heat
O	0009615	biological_process	response to virus
O	0010506	biological_process	regulation of autophagy
O	0019901	molecular_function	protein kinase binding
O	0030018	cellular_component	Z disc
O	0032731	biological_process	positive regulation of interleukin-1 beta production
O	0032760	biological_process	positive regulation of tumor necrosis factor production
O	0035556	biological_process	intracellular signal transduction
O	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
O	0042026	biological_process	protein refolding
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0043066	biological_process	negative regulation of apoptotic process
O	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
O	0043130	molecular_function	ubiquitin binding
O	0043292	cellular_component	contractile muscle fiber
O	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
O	0044183	molecular_function	protein folding chaperone
O	0045766	biological_process	positive regulation of angiogenesis
O	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
O	0051082	molecular_function	unfolded protein binding
O	0060729	biological_process	intestinal epithelial structure maintenance
O	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
O	0070062	cellular_component	extracellular exosome
O	0070527	biological_process	platelet aggregation
O	0090038	biological_process	negative regulation of protein kinase C signaling
O	0099641	biological_process	anterograde axonal protein transport
O	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
O	1904115	cellular_component	axon cytoplasm
O	2001028	biological_process	positive regulation of endothelial cell chemotaxis
O	2001234	biological_process	negative regulation of apoptotic signaling pathway
P	0000502	cellular_component	proteasome complex
P	0001533	cellular_component	cornified envelope
P	0001932	biological_process	regulation of protein phosphorylation
P	0003723	molecular_function	RNA binding
P	0005080	molecular_function	protein kinase C binding
P	0005515	molecular_function	protein binding
P	0005615	cellular_component	extracellular space
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0005819	cellular_component	spindle
P	0005829	cellular_component	cytosol
P	0005856	cellular_component	cytoskeleton
P	0005886	cellular_component	plasma membrane
P	0005925	cellular_component	focal adhesion
P	0006446	biological_process	regulation of translational initiation
P	0006457	biological_process	protein folding
P	0006986	biological_process	response to unfolded protein
P	0008426	molecular_function	protein kinase C inhibitor activity
P	0009408	biological_process	response to heat
P	0009615	biological_process	response to virus
P	0010506	biological_process	regulation of autophagy
P	0019901	molecular_function	protein kinase binding
P	0030018	cellular_component	Z disc
P	0032731	biological_process	positive regulation of interleukin-1 beta production
P	0032760	biological_process	positive regulation of tumor necrosis factor production
P	0035556	biological_process	intracellular signal transduction
P	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
P	0042026	biological_process	protein refolding
P	0042802	molecular_function	identical protein binding
P	0042803	molecular_function	protein homodimerization activity
P	0043066	biological_process	negative regulation of apoptotic process
P	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
P	0043130	molecular_function	ubiquitin binding
P	0043292	cellular_component	contractile muscle fiber
P	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
P	0044183	molecular_function	protein folding chaperone
P	0045766	biological_process	positive regulation of angiogenesis
P	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
P	0051082	molecular_function	unfolded protein binding
P	0060729	biological_process	intestinal epithelial structure maintenance
P	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
P	0070062	cellular_component	extracellular exosome
P	0070527	biological_process	platelet aggregation
P	0090038	biological_process	negative regulation of protein kinase C signaling
P	0099641	biological_process	anterograde axonal protein transport
P	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
P	1904115	cellular_component	axon cytoplasm
P	2001028	biological_process	positive regulation of endothelial cell chemotaxis
P	2001234	biological_process	negative regulation of apoptotic signaling pathway
Q	0000502	cellular_component	proteasome complex
Q	0001533	cellular_component	cornified envelope
Q	0001932	biological_process	regulation of protein phosphorylation
Q	0003723	molecular_function	RNA binding
Q	0005080	molecular_function	protein kinase C binding
Q	0005515	molecular_function	protein binding
Q	0005615	cellular_component	extracellular space
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005819	cellular_component	spindle
Q	0005829	cellular_component	cytosol
Q	0005856	cellular_component	cytoskeleton
Q	0005886	cellular_component	plasma membrane
Q	0005925	cellular_component	focal adhesion
Q	0006446	biological_process	regulation of translational initiation
Q	0006457	biological_process	protein folding
Q	0006986	biological_process	response to unfolded protein
Q	0008426	molecular_function	protein kinase C inhibitor activity
Q	0009408	biological_process	response to heat
Q	0009615	biological_process	response to virus
Q	0010506	biological_process	regulation of autophagy
Q	0019901	molecular_function	protein kinase binding
Q	0030018	cellular_component	Z disc
Q	0032731	biological_process	positive regulation of interleukin-1 beta production
Q	0032760	biological_process	positive regulation of tumor necrosis factor production
Q	0035556	biological_process	intracellular signal transduction
Q	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
Q	0042026	biological_process	protein refolding
Q	0042802	molecular_function	identical protein binding
Q	0042803	molecular_function	protein homodimerization activity
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
Q	0043130	molecular_function	ubiquitin binding
Q	0043292	cellular_component	contractile muscle fiber
Q	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
Q	0044183	molecular_function	protein folding chaperone
Q	0045766	biological_process	positive regulation of angiogenesis
Q	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
Q	0051082	molecular_function	unfolded protein binding
Q	0060729	biological_process	intestinal epithelial structure maintenance
Q	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
Q	0070062	cellular_component	extracellular exosome
Q	0070527	biological_process	platelet aggregation
Q	0090038	biological_process	negative regulation of protein kinase C signaling
Q	0099641	biological_process	anterograde axonal protein transport
Q	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Q	1904115	cellular_component	axon cytoplasm
Q	2001028	biological_process	positive regulation of endothelial cell chemotaxis
Q	2001234	biological_process	negative regulation of apoptotic signaling pathway
R	0000502	cellular_component	proteasome complex
R	0001533	cellular_component	cornified envelope
R	0001932	biological_process	regulation of protein phosphorylation
R	0003723	molecular_function	RNA binding
R	0005080	molecular_function	protein kinase C binding
R	0005515	molecular_function	protein binding
R	0005615	cellular_component	extracellular space
R	0005634	cellular_component	nucleus
R	0005737	cellular_component	cytoplasm
R	0005819	cellular_component	spindle
R	0005829	cellular_component	cytosol
R	0005856	cellular_component	cytoskeleton
R	0005886	cellular_component	plasma membrane
R	0005925	cellular_component	focal adhesion
R	0006446	biological_process	regulation of translational initiation
R	0006457	biological_process	protein folding
R	0006986	biological_process	response to unfolded protein
R	0008426	molecular_function	protein kinase C inhibitor activity
R	0009408	biological_process	response to heat
R	0009615	biological_process	response to virus
R	0010506	biological_process	regulation of autophagy
R	0019901	molecular_function	protein kinase binding
R	0030018	cellular_component	Z disc
R	0032731	biological_process	positive regulation of interleukin-1 beta production
R	0032760	biological_process	positive regulation of tumor necrosis factor production
R	0035556	biological_process	intracellular signal transduction
R	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
R	0042026	biological_process	protein refolding
R	0042802	molecular_function	identical protein binding
R	0042803	molecular_function	protein homodimerization activity
R	0043066	biological_process	negative regulation of apoptotic process
R	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
R	0043130	molecular_function	ubiquitin binding
R	0043292	cellular_component	contractile muscle fiber
R	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
R	0044183	molecular_function	protein folding chaperone
R	0045766	biological_process	positive regulation of angiogenesis
R	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
R	0051082	molecular_function	unfolded protein binding
R	0060729	biological_process	intestinal epithelial structure maintenance
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0070062	cellular_component	extracellular exosome
R	0070527	biological_process	platelet aggregation
R	0090038	biological_process	negative regulation of protein kinase C signaling
R	0099641	biological_process	anterograde axonal protein transport
R	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
R	1904115	cellular_component	axon cytoplasm
R	2001028	biological_process	positive regulation of endothelial cell chemotaxis
R	2001234	biological_process	negative regulation of apoptotic signaling pathway
S	0000502	cellular_component	proteasome complex
S	0001533	cellular_component	cornified envelope
S	0001932	biological_process	regulation of protein phosphorylation
S	0003723	molecular_function	RNA binding
S	0005080	molecular_function	protein kinase C binding
S	0005515	molecular_function	protein binding
S	0005615	cellular_component	extracellular space
S	0005634	cellular_component	nucleus
S	0005737	cellular_component	cytoplasm
S	0005819	cellular_component	spindle
S	0005829	cellular_component	cytosol
S	0005856	cellular_component	cytoskeleton
S	0005886	cellular_component	plasma membrane
S	0005925	cellular_component	focal adhesion
S	0006446	biological_process	regulation of translational initiation
S	0006457	biological_process	protein folding
S	0006986	biological_process	response to unfolded protein
S	0008426	molecular_function	protein kinase C inhibitor activity
S	0009408	biological_process	response to heat
S	0009615	biological_process	response to virus
S	0010506	biological_process	regulation of autophagy
S	0019901	molecular_function	protein kinase binding
S	0030018	cellular_component	Z disc
S	0032731	biological_process	positive regulation of interleukin-1 beta production
S	0032760	biological_process	positive regulation of tumor necrosis factor production
S	0035556	biological_process	intracellular signal transduction
S	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
S	0042026	biological_process	protein refolding
S	0042802	molecular_function	identical protein binding
S	0042803	molecular_function	protein homodimerization activity
S	0043066	biological_process	negative regulation of apoptotic process
S	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
S	0043130	molecular_function	ubiquitin binding
S	0043292	cellular_component	contractile muscle fiber
S	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
S	0044183	molecular_function	protein folding chaperone
S	0045766	biological_process	positive regulation of angiogenesis
S	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
S	0051082	molecular_function	unfolded protein binding
S	0060729	biological_process	intestinal epithelial structure maintenance
S	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
S	0070062	cellular_component	extracellular exosome
S	0070527	biological_process	platelet aggregation
S	0090038	biological_process	negative regulation of protein kinase C signaling
S	0099641	biological_process	anterograde axonal protein transport
S	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
S	1904115	cellular_component	axon cytoplasm
S	2001028	biological_process	positive regulation of endothelial cell chemotaxis
S	2001234	biological_process	negative regulation of apoptotic signaling pathway
T	0000502	cellular_component	proteasome complex
T	0001533	cellular_component	cornified envelope
T	0001932	biological_process	regulation of protein phosphorylation
T	0003723	molecular_function	RNA binding
T	0005080	molecular_function	protein kinase C binding
T	0005515	molecular_function	protein binding
T	0005615	cellular_component	extracellular space
T	0005634	cellular_component	nucleus
T	0005737	cellular_component	cytoplasm
T	0005819	cellular_component	spindle
T	0005829	cellular_component	cytosol
T	0005856	cellular_component	cytoskeleton
T	0005886	cellular_component	plasma membrane
T	0005925	cellular_component	focal adhesion
T	0006446	biological_process	regulation of translational initiation
T	0006457	biological_process	protein folding
T	0006986	biological_process	response to unfolded protein
T	0008426	molecular_function	protein kinase C inhibitor activity
T	0009408	biological_process	response to heat
T	0009615	biological_process	response to virus
T	0010506	biological_process	regulation of autophagy
T	0019901	molecular_function	protein kinase binding
T	0030018	cellular_component	Z disc
T	0032731	biological_process	positive regulation of interleukin-1 beta production
T	0032760	biological_process	positive regulation of tumor necrosis factor production
T	0035556	biological_process	intracellular signal transduction
T	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
T	0042026	biological_process	protein refolding
T	0042802	molecular_function	identical protein binding
T	0042803	molecular_function	protein homodimerization activity
T	0043066	biological_process	negative regulation of apoptotic process
T	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
T	0043130	molecular_function	ubiquitin binding
T	0043292	cellular_component	contractile muscle fiber
T	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
T	0044183	molecular_function	protein folding chaperone
T	0045766	biological_process	positive regulation of angiogenesis
T	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
T	0051082	molecular_function	unfolded protein binding
T	0060729	biological_process	intestinal epithelial structure maintenance
T	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
T	0070062	cellular_component	extracellular exosome
T	0070527	biological_process	platelet aggregation
T	0090038	biological_process	negative regulation of protein kinase C signaling
T	0099641	biological_process	anterograde axonal protein transport
T	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
T	1904115	cellular_component	axon cytoplasm
T	2001028	biological_process	positive regulation of endothelial cell chemotaxis
T	2001234	biological_process	negative regulation of apoptotic signaling pathway
U	0000502	cellular_component	proteasome complex
U	0001533	cellular_component	cornified envelope
U	0001932	biological_process	regulation of protein phosphorylation
U	0003723	molecular_function	RNA binding
U	0005080	molecular_function	protein kinase C binding
U	0005515	molecular_function	protein binding
U	0005615	cellular_component	extracellular space
U	0005634	cellular_component	nucleus
U	0005737	cellular_component	cytoplasm
U	0005819	cellular_component	spindle
U	0005829	cellular_component	cytosol
U	0005856	cellular_component	cytoskeleton
U	0005886	cellular_component	plasma membrane
U	0005925	cellular_component	focal adhesion
U	0006446	biological_process	regulation of translational initiation
U	0006457	biological_process	protein folding
U	0006986	biological_process	response to unfolded protein
U	0008426	molecular_function	protein kinase C inhibitor activity
U	0009408	biological_process	response to heat
U	0009615	biological_process	response to virus
U	0010506	biological_process	regulation of autophagy
U	0019901	molecular_function	protein kinase binding
U	0030018	cellular_component	Z disc
U	0032731	biological_process	positive regulation of interleukin-1 beta production
U	0032760	biological_process	positive regulation of tumor necrosis factor production
U	0035556	biological_process	intracellular signal transduction
U	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
U	0042026	biological_process	protein refolding
U	0042802	molecular_function	identical protein binding
U	0042803	molecular_function	protein homodimerization activity
U	0043066	biological_process	negative regulation of apoptotic process
U	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
U	0043130	molecular_function	ubiquitin binding
U	0043292	cellular_component	contractile muscle fiber
U	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
U	0044183	molecular_function	protein folding chaperone
U	0045766	biological_process	positive regulation of angiogenesis
U	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
U	0051082	molecular_function	unfolded protein binding
U	0060729	biological_process	intestinal epithelial structure maintenance
U	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
U	0070062	cellular_component	extracellular exosome
U	0070527	biological_process	platelet aggregation
U	0090038	biological_process	negative regulation of protein kinase C signaling
U	0099641	biological_process	anterograde axonal protein transport
U	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
U	1904115	cellular_component	axon cytoplasm
U	2001028	biological_process	positive regulation of endothelial cell chemotaxis
U	2001234	biological_process	negative regulation of apoptotic signaling pathway
V	0000502	cellular_component	proteasome complex
V	0001533	cellular_component	cornified envelope
V	0001932	biological_process	regulation of protein phosphorylation
V	0003723	molecular_function	RNA binding
V	0005080	molecular_function	protein kinase C binding
V	0005515	molecular_function	protein binding
V	0005615	cellular_component	extracellular space
V	0005634	cellular_component	nucleus
V	0005737	cellular_component	cytoplasm
V	0005819	cellular_component	spindle
V	0005829	cellular_component	cytosol
V	0005856	cellular_component	cytoskeleton
V	0005886	cellular_component	plasma membrane
V	0005925	cellular_component	focal adhesion
V	0006446	biological_process	regulation of translational initiation
V	0006457	biological_process	protein folding
V	0006986	biological_process	response to unfolded protein
V	0008426	molecular_function	protein kinase C inhibitor activity
V	0009408	biological_process	response to heat
V	0009615	biological_process	response to virus
V	0010506	biological_process	regulation of autophagy
V	0019901	molecular_function	protein kinase binding
V	0030018	cellular_component	Z disc
V	0032731	biological_process	positive regulation of interleukin-1 beta production
V	0032760	biological_process	positive regulation of tumor necrosis factor production
V	0035556	biological_process	intracellular signal transduction
V	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
V	0042026	biological_process	protein refolding
V	0042802	molecular_function	identical protein binding
V	0042803	molecular_function	protein homodimerization activity
V	0043066	biological_process	negative regulation of apoptotic process
V	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
V	0043130	molecular_function	ubiquitin binding
V	0043292	cellular_component	contractile muscle fiber
V	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
V	0044183	molecular_function	protein folding chaperone
V	0045766	biological_process	positive regulation of angiogenesis
V	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
V	0051082	molecular_function	unfolded protein binding
V	0060729	biological_process	intestinal epithelial structure maintenance
V	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
V	0070062	cellular_component	extracellular exosome
V	0070527	biological_process	platelet aggregation
V	0090038	biological_process	negative regulation of protein kinase C signaling
V	0099641	biological_process	anterograde axonal protein transport
V	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
V	1904115	cellular_component	axon cytoplasm
V	2001028	biological_process	positive regulation of endothelial cell chemotaxis
V	2001234	biological_process	negative regulation of apoptotic signaling pathway
W	0000502	cellular_component	proteasome complex
W	0001533	cellular_component	cornified envelope
W	0001932	biological_process	regulation of protein phosphorylation
W	0003723	molecular_function	RNA binding
W	0005080	molecular_function	protein kinase C binding
W	0005515	molecular_function	protein binding
W	0005615	cellular_component	extracellular space
W	0005634	cellular_component	nucleus
W	0005737	cellular_component	cytoplasm
W	0005819	cellular_component	spindle
W	0005829	cellular_component	cytosol
W	0005856	cellular_component	cytoskeleton
W	0005886	cellular_component	plasma membrane
W	0005925	cellular_component	focal adhesion
W	0006446	biological_process	regulation of translational initiation
W	0006457	biological_process	protein folding
W	0006986	biological_process	response to unfolded protein
W	0008426	molecular_function	protein kinase C inhibitor activity
W	0009408	biological_process	response to heat
W	0009615	biological_process	response to virus
W	0010506	biological_process	regulation of autophagy
W	0019901	molecular_function	protein kinase binding
W	0030018	cellular_component	Z disc
W	0032731	biological_process	positive regulation of interleukin-1 beta production
W	0032760	biological_process	positive regulation of tumor necrosis factor production
W	0035556	biological_process	intracellular signal transduction
W	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
W	0042026	biological_process	protein refolding
W	0042802	molecular_function	identical protein binding
W	0042803	molecular_function	protein homodimerization activity
W	0043066	biological_process	negative regulation of apoptotic process
W	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
W	0043130	molecular_function	ubiquitin binding
W	0043292	cellular_component	contractile muscle fiber
W	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
W	0044183	molecular_function	protein folding chaperone
W	0045766	biological_process	positive regulation of angiogenesis
W	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
W	0051082	molecular_function	unfolded protein binding
W	0060729	biological_process	intestinal epithelial structure maintenance
W	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
W	0070062	cellular_component	extracellular exosome
W	0070527	biological_process	platelet aggregation
W	0090038	biological_process	negative regulation of protein kinase C signaling
W	0099641	biological_process	anterograde axonal protein transport
W	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
W	1904115	cellular_component	axon cytoplasm
W	2001028	biological_process	positive regulation of endothelial cell chemotaxis
W	2001234	biological_process	negative regulation of apoptotic signaling pathway
X	0000502	cellular_component	proteasome complex
X	0001533	cellular_component	cornified envelope
X	0001932	biological_process	regulation of protein phosphorylation
X	0003723	molecular_function	RNA binding
X	0005080	molecular_function	protein kinase C binding
X	0005515	molecular_function	protein binding
X	0005615	cellular_component	extracellular space
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005819	cellular_component	spindle
X	0005829	cellular_component	cytosol
X	0005856	cellular_component	cytoskeleton
X	0005886	cellular_component	plasma membrane
X	0005925	cellular_component	focal adhesion
X	0006446	biological_process	regulation of translational initiation
X	0006457	biological_process	protein folding
X	0006986	biological_process	response to unfolded protein
X	0008426	molecular_function	protein kinase C inhibitor activity
X	0009408	biological_process	response to heat
X	0009615	biological_process	response to virus
X	0010506	biological_process	regulation of autophagy
X	0019901	molecular_function	protein kinase binding
X	0030018	cellular_component	Z disc
X	0032731	biological_process	positive regulation of interleukin-1 beta production
X	0032760	biological_process	positive regulation of tumor necrosis factor production
X	0035556	biological_process	intracellular signal transduction
X	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
X	0042026	biological_process	protein refolding
X	0042802	molecular_function	identical protein binding
X	0042803	molecular_function	protein homodimerization activity
X	0043066	biological_process	negative regulation of apoptotic process
X	0043122	biological_process	regulation of canonical NF-kappaB signal transduction
X	0043130	molecular_function	ubiquitin binding
X	0043292	cellular_component	contractile muscle fiber
X	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
X	0044183	molecular_function	protein folding chaperone
X	0045766	biological_process	positive regulation of angiogenesis
X	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
X	0051082	molecular_function	unfolded protein binding
X	0060729	biological_process	intestinal epithelial structure maintenance
X	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
X	0070062	cellular_component	extracellular exosome
X	0070527	biological_process	platelet aggregation
X	0090038	biological_process	negative regulation of protein kinase C signaling
X	0099641	biological_process	anterograde axonal protein transport
X	1902176	biological_process	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
X	1904115	cellular_component	axon cytoplasm
X	2001028	biological_process	positive regulation of endothelial cell chemotaxis
X	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	13
Details	Modified residue: {"description":"Phosphoserine; by MAPKAPK2 and MAPKAPK3","evidences":[{"source":"PubMed","id":"10383393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1332886","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8774846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18088087","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P42930","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5","evidences":[{"source":"PubMed","id":"10383393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1332886","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15976317","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1730670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19166925","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8774846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	Modified residue: {"description":"Phosphoserine; by MAPKAPK2, MAPKAPK3 and MAPKAPK5","evidences":[{"source":"PubMed","id":"10383393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1332886","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15976317","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1730670","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19166925","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8774846","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2009","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Waridel P.","Quadroni M."]}},{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	23
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	24
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	23
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	7
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---