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6DV2

Crystal Structure of Human Mitochondrial Trifunctional Protein

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
A0003985molecular_functionacetyl-CoA C-acetyltransferase activity
A0003988molecular_functionacetyl-CoA C-acyltransferase activity
A0004300molecular_functionenoyl-CoA hydratase activity
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005740cellular_componentmitochondrial envelope
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005783cellular_componentendoplasmic reticulum
A0006631biological_processfatty acid metabolic process
A0006635biological_processfatty acid beta-oxidation
A0010467biological_processgene expression
A0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
A0016746molecular_functionacyltransferase activity
A0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
A0042645cellular_componentmitochondrial nucleoid
A0050633molecular_functionacetyl-CoA C-myristoyltransferase activity
A0071222biological_processcellular response to lipopolysaccharide
A0106222molecular_functionlncRNA binding
B0003723molecular_functionRNA binding
B0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
B0003985molecular_functionacetyl-CoA C-acetyltransferase activity
B0003988molecular_functionacetyl-CoA C-acyltransferase activity
B0004300molecular_functionenoyl-CoA hydratase activity
B0005515molecular_functionprotein binding
B0005739cellular_componentmitochondrion
B0005740cellular_componentmitochondrial envelope
B0005741cellular_componentmitochondrial outer membrane
B0005743cellular_componentmitochondrial inner membrane
B0005783cellular_componentendoplasmic reticulum
B0006631biological_processfatty acid metabolic process
B0006635biological_processfatty acid beta-oxidation
B0010467biological_processgene expression
B0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
B0016746molecular_functionacyltransferase activity
B0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
B0042645cellular_componentmitochondrial nucleoid
B0050633molecular_functionacetyl-CoA C-myristoyltransferase activity
B0071222biological_processcellular response to lipopolysaccharide
B0106222molecular_functionlncRNA binding
C0003723molecular_functionRNA binding
C0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
C0003985molecular_functionacetyl-CoA C-acetyltransferase activity
C0003988molecular_functionacetyl-CoA C-acyltransferase activity
C0004300molecular_functionenoyl-CoA hydratase activity
C0005515molecular_functionprotein binding
C0005739cellular_componentmitochondrion
C0005740cellular_componentmitochondrial envelope
C0005741cellular_componentmitochondrial outer membrane
C0005743cellular_componentmitochondrial inner membrane
C0005783cellular_componentendoplasmic reticulum
C0006631biological_processfatty acid metabolic process
C0006635biological_processfatty acid beta-oxidation
C0010467biological_processgene expression
C0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
C0016746molecular_functionacyltransferase activity
C0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
C0042645cellular_componentmitochondrial nucleoid
C0050633molecular_functionacetyl-CoA C-myristoyltransferase activity
C0071222biological_processcellular response to lipopolysaccharide
C0106222molecular_functionlncRNA binding
D0003723molecular_functionRNA binding
D0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
D0003985molecular_functionacetyl-CoA C-acetyltransferase activity
D0003988molecular_functionacetyl-CoA C-acyltransferase activity
D0004300molecular_functionenoyl-CoA hydratase activity
D0005515molecular_functionprotein binding
D0005739cellular_componentmitochondrion
D0005740cellular_componentmitochondrial envelope
D0005741cellular_componentmitochondrial outer membrane
D0005743cellular_componentmitochondrial inner membrane
D0005783cellular_componentendoplasmic reticulum
D0006631biological_processfatty acid metabolic process
D0006635biological_processfatty acid beta-oxidation
D0010467biological_processgene expression
D0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
D0016746molecular_functionacyltransferase activity
D0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
D0042645cellular_componentmitochondrial nucleoid
D0050633molecular_functionacetyl-CoA C-myristoyltransferase activity
D0071222biological_processcellular response to lipopolysaccharide
D0106222molecular_functionlncRNA binding
E0003723molecular_functionRNA binding
E0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
E0003985molecular_functionacetyl-CoA C-acetyltransferase activity
E0003988molecular_functionacetyl-CoA C-acyltransferase activity
E0004300molecular_functionenoyl-CoA hydratase activity
E0005515molecular_functionprotein binding
E0005739cellular_componentmitochondrion
E0005740cellular_componentmitochondrial envelope
E0005741cellular_componentmitochondrial outer membrane
E0005743cellular_componentmitochondrial inner membrane
E0005783cellular_componentendoplasmic reticulum
E0006631biological_processfatty acid metabolic process
E0006635biological_processfatty acid beta-oxidation
E0010467biological_processgene expression
E0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
E0016746molecular_functionacyltransferase activity
E0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
E0042645cellular_componentmitochondrial nucleoid
E0050633molecular_functionacetyl-CoA C-myristoyltransferase activity
E0071222biological_processcellular response to lipopolysaccharide
E0106222molecular_functionlncRNA binding
F0003723molecular_functionRNA binding
F0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
F0003985molecular_functionacetyl-CoA C-acetyltransferase activity
F0003988molecular_functionacetyl-CoA C-acyltransferase activity
F0004300molecular_functionenoyl-CoA hydratase activity
F0005515molecular_functionprotein binding
F0005739cellular_componentmitochondrion
F0005740cellular_componentmitochondrial envelope
F0005741cellular_componentmitochondrial outer membrane
F0005743cellular_componentmitochondrial inner membrane
F0005783cellular_componentendoplasmic reticulum
F0006631biological_processfatty acid metabolic process
F0006635biological_processfatty acid beta-oxidation
F0010467biological_processgene expression
F0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
F0016746molecular_functionacyltransferase activity
F0016747molecular_functionacyltransferase activity, transferring groups other than amino-acyl groups
F0042645cellular_componentmitochondrial nucleoid
F0050633molecular_functionacetyl-CoA C-myristoyltransferase activity
F0071222biological_processcellular response to lipopolysaccharide
F0106222molecular_functionlncRNA binding
G0000062molecular_functionfatty-acyl-CoA binding
G0003824molecular_functioncatalytic activity
G0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
G0003985molecular_functionacetyl-CoA C-acetyltransferase activity
G0003988molecular_functionacetyl-CoA C-acyltransferase activity
G0004300molecular_functionenoyl-CoA hydratase activity
G0005515molecular_functionprotein binding
G0005739cellular_componentmitochondrion
G0005743cellular_componentmitochondrial inner membrane
G0006631biological_processfatty acid metabolic process
G0006635biological_processfatty acid beta-oxidation
G0009410biological_processresponse to xenobiotic stimulus
G0016491molecular_functionoxidoreductase activity
G0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
G0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
G0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G0016740molecular_functiontransferase activity
G0016829molecular_functionlyase activity
G0018812molecular_function3-hydroxyacyl-CoA dehydratase activity
G0032868biological_processresponse to insulin
G0035965biological_processcardiolipin acyl-chain remodeling
G0042645cellular_componentmitochondrial nucleoid
G0044877molecular_functionprotein-containing complex binding
G0051287molecular_functionNAD binding
G0070403molecular_functionNAD+ binding
H0000062molecular_functionfatty-acyl-CoA binding
H0003824molecular_functioncatalytic activity
H0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
H0003985molecular_functionacetyl-CoA C-acetyltransferase activity
H0003988molecular_functionacetyl-CoA C-acyltransferase activity
H0004300molecular_functionenoyl-CoA hydratase activity
H0005515molecular_functionprotein binding
H0005739cellular_componentmitochondrion
H0005743cellular_componentmitochondrial inner membrane
H0006631biological_processfatty acid metabolic process
H0006635biological_processfatty acid beta-oxidation
H0009410biological_processresponse to xenobiotic stimulus
H0016491molecular_functionoxidoreductase activity
H0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
H0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
H0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H0016740molecular_functiontransferase activity
H0016829molecular_functionlyase activity
H0018812molecular_function3-hydroxyacyl-CoA dehydratase activity
H0032868biological_processresponse to insulin
H0035965biological_processcardiolipin acyl-chain remodeling
H0042645cellular_componentmitochondrial nucleoid
H0044877molecular_functionprotein-containing complex binding
H0051287molecular_functionNAD binding
H0070403molecular_functionNAD+ binding
I0000062molecular_functionfatty-acyl-CoA binding
I0003824molecular_functioncatalytic activity
I0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
I0003985molecular_functionacetyl-CoA C-acetyltransferase activity
I0003988molecular_functionacetyl-CoA C-acyltransferase activity
I0004300molecular_functionenoyl-CoA hydratase activity
I0005515molecular_functionprotein binding
I0005739cellular_componentmitochondrion
I0005743cellular_componentmitochondrial inner membrane
I0006631biological_processfatty acid metabolic process
I0006635biological_processfatty acid beta-oxidation
I0009410biological_processresponse to xenobiotic stimulus
I0016491molecular_functionoxidoreductase activity
I0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
I0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
I0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I0016740molecular_functiontransferase activity
I0016829molecular_functionlyase activity
I0018812molecular_function3-hydroxyacyl-CoA dehydratase activity
I0032868biological_processresponse to insulin
I0035965biological_processcardiolipin acyl-chain remodeling
I0042645cellular_componentmitochondrial nucleoid
I0044877molecular_functionprotein-containing complex binding
I0051287molecular_functionNAD binding
I0070403molecular_functionNAD+ binding
J0000062molecular_functionfatty-acyl-CoA binding
J0003824molecular_functioncatalytic activity
J0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
J0003985molecular_functionacetyl-CoA C-acetyltransferase activity
J0003988molecular_functionacetyl-CoA C-acyltransferase activity
J0004300molecular_functionenoyl-CoA hydratase activity
J0005515molecular_functionprotein binding
J0005739cellular_componentmitochondrion
J0005743cellular_componentmitochondrial inner membrane
J0006631biological_processfatty acid metabolic process
J0006635biological_processfatty acid beta-oxidation
J0009410biological_processresponse to xenobiotic stimulus
J0016491molecular_functionoxidoreductase activity
J0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
J0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
J0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J0016740molecular_functiontransferase activity
J0016829molecular_functionlyase activity
J0018812molecular_function3-hydroxyacyl-CoA dehydratase activity
J0032868biological_processresponse to insulin
J0035965biological_processcardiolipin acyl-chain remodeling
J0042645cellular_componentmitochondrial nucleoid
J0044877molecular_functionprotein-containing complex binding
J0051287molecular_functionNAD binding
J0070403molecular_functionNAD+ binding
K0000062molecular_functionfatty-acyl-CoA binding
K0003824molecular_functioncatalytic activity
K0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
K0003985molecular_functionacetyl-CoA C-acetyltransferase activity
K0003988molecular_functionacetyl-CoA C-acyltransferase activity
K0004300molecular_functionenoyl-CoA hydratase activity
K0005515molecular_functionprotein binding
K0005739cellular_componentmitochondrion
K0005743cellular_componentmitochondrial inner membrane
K0006631biological_processfatty acid metabolic process
K0006635biological_processfatty acid beta-oxidation
K0009410biological_processresponse to xenobiotic stimulus
K0016491molecular_functionoxidoreductase activity
K0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
K0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
K0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K0016740molecular_functiontransferase activity
K0016829molecular_functionlyase activity
K0018812molecular_function3-hydroxyacyl-CoA dehydratase activity
K0032868biological_processresponse to insulin
K0035965biological_processcardiolipin acyl-chain remodeling
K0042645cellular_componentmitochondrial nucleoid
K0044877molecular_functionprotein-containing complex binding
K0051287molecular_functionNAD binding
K0070403molecular_functionNAD+ binding
L0000062molecular_functionfatty-acyl-CoA binding
L0003824molecular_functioncatalytic activity
L0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
L0003985molecular_functionacetyl-CoA C-acetyltransferase activity
L0003988molecular_functionacetyl-CoA C-acyltransferase activity
L0004300molecular_functionenoyl-CoA hydratase activity
L0005515molecular_functionprotein binding
L0005739cellular_componentmitochondrion
L0005743cellular_componentmitochondrial inner membrane
L0006631biological_processfatty acid metabolic process
L0006635biological_processfatty acid beta-oxidation
L0009410biological_processresponse to xenobiotic stimulus
L0016491molecular_functionoxidoreductase activity
L0016507cellular_componentmitochondrial fatty acid beta-oxidation multienzyme complex
L0016509molecular_functionlong-chain-3-hydroxyacyl-CoA dehydrogenase activity
L0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L0016740molecular_functiontransferase activity
L0016829molecular_functionlyase activity
L0018812molecular_function3-hydroxyacyl-CoA dehydratase activity
L0032868biological_processresponse to insulin
L0035965biological_processcardiolipin acyl-chain remodeling
L0042645cellular_componentmitochondrial nucleoid
L0044877molecular_functionprotein-containing complex binding
L0051287molecular_functionNAD binding
L0070403molecular_functionNAD+ binding
Functional Information from PROSITE/UniProt
site_idPS00098
Number of Residues19
DetailsTHIOLASE_1 Thiolases acyl-enzyme intermediate signature. VTMaCISANqAMttgvglI
ChainResidueDetails
AVAL134-ILE152

site_idPS00099
Number of Residues14
DetailsTHIOLASE_3 Thiolases active site. GLVAACAAgGqGhA
ChainResidueDetails
AGLY453-ALA466

site_idPS00737
Number of Residues17
DetailsTHIOLASE_2 Thiolases signature 2. NnwGGsLSlGHPfGaTG
ChainResidueDetails
AASN418-GLY434

site_idPS00067
Number of Residues25
Details3HCDH 3-hydroxyacyl-CoA dehydrogenase signature. DgpGFYtTRclaPMMsevir.ILqeG
ChainResidueDetails
GASP541-GLY565

site_idPS00166
Number of Residues21
DetailsENOYL_COA_HYDRATASE Enoyl-CoA hydratase/isomerase signature. VAaINGsclGGGlevaIsCQY
ChainResidueDetails
GVAL138-TYR158

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: For hydroxyacyl-coenzyme A dehydrogenase activity => ECO:0000269|PubMed:8770876
ChainResidueDetails
GGLU510
HGLU510
IGLU510
JGLU510
KGLU510
LGLU510

site_idSWS_FT_FI2
Number of Residues12
DetailsSITE: Important for long-chain enoyl-CoA hydratase activity => ECO:0000305|PubMed:30850536
ChainResidueDetails
GGLU151
GGLU173
HGLU151
HGLU173
IGLU151
IGLU173
JGLU151
JGLU173
KGLU151
KGLU173
LGLU151
LGLU173

site_idSWS_FT_FI3
Number of Residues6
DetailsSITE: Important for hydroxyacyl-coenzyme A dehydrogenase activity => ECO:0000305|PubMed:30850536
ChainResidueDetails
GHIS498
HHIS498
IHIS498
JHIS498
KHIS498
LHIS498

site_idSWS_FT_FI4
Number of Residues114
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8BMS1
ChainResidueDetails
GLYS46
GLYS60
GLYS166
GLYS214
GLYS249
GLYS303
GLYS326
GLYS334
GLYS350
GLYS406
GLYS411
GLYS460
GLYS505
GLYS519
GLYS569
GLYS644
GLYS664
GLYS728
GLYS759
HLYS46
HLYS60
HLYS166
HLYS214
HLYS249
HLYS303
HLYS326
HLYS334
HLYS350
HLYS406
HLYS411
HLYS460
HLYS505
HLYS519
HLYS569
HLYS644
HLYS664
HLYS728
HLYS759
ILYS46
ILYS60
ILYS166
ILYS214
ILYS249
ILYS303
ILYS326
ILYS334
ILYS350
ILYS406
ILYS411
ILYS460
ILYS505
ILYS519
ILYS569
ILYS644
ILYS664
ILYS728
ILYS759
JLYS46
JLYS60
JLYS166
JLYS214
JLYS249
JLYS303
JLYS326
JLYS334
JLYS350
JLYS406
JLYS411
JLYS460
JLYS505
JLYS519
JLYS569
JLYS644
JLYS664
JLYS728
JLYS759
KLYS46
KLYS60
KLYS166
KLYS214
KLYS249
KLYS303
KLYS326
KLYS334
KLYS350
KLYS406
KLYS411
KLYS460
KLYS505
KLYS519
KLYS569
KLYS644
KLYS664
KLYS728
KLYS759
LLYS46
LLYS60
LLYS166
LLYS214
LLYS249
LLYS303
LLYS326
LLYS334
LLYS350
LLYS406
LLYS411
LLYS460
LLYS505
LLYS519
LLYS569
LLYS644
LLYS664
LLYS728
LLYS759

site_idSWS_FT_FI5
Number of Residues24
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BMS1
ChainResidueDetails
GLYS735
HLYS129
HLYS289
HLYS353
HLYS735
ILYS129
ILYS289
ILYS353
ILYS735
JLYS129
JLYS289
JLYS353
JLYS735
KLYS129
KLYS289
KLYS353
KLYS735
LLYS129
LLYS289
LLYS353
LLYS735
GLYS129
GLYS289
GLYS353

site_idSWS_FT_FI6
Number of Residues36
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BMS1
ChainResidueDetails
GLYS213
GLYS230
GLYS415
GLYS440
GLYS634
GLYS646
HLYS213
HLYS230
HLYS415
HLYS440
HLYS634
HLYS646
ILYS213
ILYS230
ILYS415
ILYS440
ILYS634
ILYS646
JLYS213
JLYS230
JLYS415
JLYS440
JLYS634
JLYS646
KLYS213
KLYS230
KLYS415
KLYS440
KLYS634
KLYS646
LLYS213
LLYS230
LLYS415
LLYS440
LLYS634
LLYS646

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
GLYS540
HLYS295
HLYS540
ILYS295
ILYS540
JLYS295
JLYS540
KLYS295
KLYS540
LLYS295
LLYS540
ELYS298
ELYS348
ELYS361
FLYS298
FLYS348
FLYS361
GLYS295

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BMS1
ChainResidueDetails
GSER316
HSER316
ISER316
JSER316
KSER316
LSER316

site_idSWS_FT_FI9
Number of Residues6
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
GTHR395
HTHR395
ITHR395
JTHR395
KTHR395
LTHR395

site_idSWS_FT_FI10
Number of Residues6
DetailsMOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:Q8BMS1
ChainResidueDetails
GARG399
HARG399
IARG399
JARG399
KARG399
LARG399

site_idSWS_FT_FI11
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q64428
ChainResidueDetails
GSER419
GSER650
HSER419
HSER650
ISER419
ISER650
JSER419
JSER650
KSER419
KSER650
LSER419
LSER650

site_idSWS_FT_FI12
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
GSER756
HSER756
ISER756
JSER756
KSER756
LSER756

220472

PDB entries from 2024-05-29

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