Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
| A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
| B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
| B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue K5C A 601 |
| Chain | Residue |
| A | LYS101 |
| A | LEU227 |
| A | TRP229 |
| A | LEU234 |
| A | HIS235 |
| A | TYR318 |
| A | HOH790 |
| A | HOH850 |
| A | HOH869 |
| B | PRO95 |
| B | GLU138 |
| A | LYS103 |
| B | HOH732 |
| A | LYS104 |
| A | SER105 |
| A | ALA106 |
| A | TYR181 |
| A | TYR188 |
| A | GLY190 |
| A | PRO225 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | ASP443 |
| A | ASP498 |
| A | ASP549 |
| A | HOH735 |
| A | HOH779 |
| A | HOH818 |
| A | HOH872 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | MET41 |
| A | LYS73 |
| A | TYR146 |
| A | PRO150 |
| A | GLN151 |
| A | HOH821 |
| A | HOH919 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | LYS331 |
| A | GLY333 |
| A | GLN334 |
| A | LYS512 |
| A | HOH824 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | LYS476 |
| A | SER515 |
| A | GLU516 |
| A | LEU517 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | TRP426 |
| A | TYR427 |
| A | GLN428 |
| A | LEU525 |
| A | LYS528 |
| A | GLU529 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 607 |
| Chain | Residue |
| A | GLU6 |
| A | LYS166 |
| B | ILE50 |
| B | GLY51 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 608 |
| Chain | Residue |
| A | THR377 |
| A | HOH729 |
| B | THR400 |
| B | DMS501 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 609 |
| Chain | Residue |
| A | LYS166 |
| A | PRO170 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 610 |
| Chain | Residue |
| A | ASP488 |
| A | HOH816 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 611 |
| Chain | Residue |
| A | THR473 |
| A | ASN474 |
| A | GLN475 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 612 |
| Chain | Residue |
| A | SER268 |
| A | LYS353 |
| A | LYS374 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 613 |
| Chain | Residue |
| A | LEU425 |
| A | TRP426 |
| A | TYR427 |
| A | GLN509 |
| A | ASP511 |
| A | HOH847 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 614 |
| Chain | Residue |
| A | LEU486 |
| A | SER489 |
| A | GLY490 |
| A | LEU491 |
| A | GLN524 |
| A | LYS528 |
| site_id | AD6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 615 |
| Chain | Residue |
| A | GLU404 |
| A | TYR405 |
| A | TRP406 |
| A | GLN507 |
| A | GLN509 |
| B | LYS424 |
| B | SO4503 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 616 |
| Chain | Residue |
| A | ASP324 |
| A | LEU325 |
| A | LYS385 |
| A | THR386 |
| A | LYS388 |
| A | HOH812 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 617 |
| Chain | Residue |
| A | TYR342 |
| A | PRO345 |
| A | PHE346 |
| A | ASN348 |
| A | HOH732 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue DMS B 501 |
| Chain | Residue |
| B | THR27 |
| B | LYS30 |
| B | THR400 |
| B | TRP401 |
| B | GLU404 |
| B | HOH657 |
| B | HOH778 |
| A | ILE380 |
| A | EDO608 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| A | GLN85 |
| B | PRO55 |
| B | TYR56 |
| B | LYS126 |
| B | HOH733 |
| B | HOH756 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| A | THR403 |
| A | GLU404 |
| A | EDO615 |
| A | HOH738 |
| B | LYS331 |
| B | GLN332 |
| B | GLY333 |
| B | LYS424 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| A | GLU138 |
| A | GLN500 |
| B | ASN265 |
| B | GLN269 |
| B | LEU422 |
| B | TRP426 |
| B | HOH601 |
| B | HOH625 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 505 |
| Chain | Residue |
| B | ILE274 |
| B | LYS275 |
| B | VAL276 |
| B | ARG277 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 506 |
| Chain | Residue |
| B | HIS235 |
| B | TRP239 |
| B | HOH784 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 507 |
| Chain | Residue |
| B | GLU328 |
| B | ILE329 |
| B | GLN330 |
| B | PRO392 |
| B | PRO421 |
| B | HOH674 |
| B | HOH766 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | VAL75 |
| B | PHE77 |
| B | ASN81 |
| B | GLY152 |
| B | TRP410 |
| B | ILE411 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | THR386 |
| B | GLU413 |
| B | HOH671 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | TRP24 |
| B | GLU396 |
| B | GLU399 |
| B | THR400 |
| B | TRP402 |
| B | HOH630 |
| site_id | AF1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | LYS238 |
| B | GLN242 |
| B | TYR339 |
| B | GLY352 |
| B | LYS353 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 512 |
| Chain | Residue |
| A | TRP88 |
| B | LYS20 |
| B | LYS22 |
| B | PRO55 |
| B | HOH670 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 513 |
| Chain | Residue |
| B | GLU248 |
| B | LYS249 |
| B | THR362 |
| B | HOH650 |
| B | HOH664 |
| B | HOH788 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 190 |
| Details | Domain: {"description":"Reverse transcriptase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00405","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Region: {"description":"RT 'primer grip'"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Motif: {"description":"Tryptophan repeat motif"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Essential for RT p66/p51 heterodimerization"} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Cleavage; by viral protease; partial"} |
