Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DU7

Glutathione reductase from Streptococcus pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
A	0005829	cellular_component	cytosol
A	0006749	biological_process	glutathione metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
A	0034599	biological_process	cellular response to oxidative stress
A	0045454	biological_process	cell redox homeostasis
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0050661	molecular_function	NADP binding
A	0098869	biological_process	cellular oxidant detoxification
B	0000166	molecular_function	nucleotide binding
B	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
B	0005829	cellular_component	cytosol
B	0006749	biological_process	glutathione metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
B	0034599	biological_process	cellular response to oxidative stress
B	0045454	biological_process	cell redox homeostasis
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0050661	molecular_function	NADP binding
B	0098869	biological_process	cellular oxidant detoxification
C	0000166	molecular_function	nucleotide binding
C	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
C	0005829	cellular_component	cytosol
C	0006749	biological_process	glutathione metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
C	0034599	biological_process	cellular response to oxidative stress
C	0045454	biological_process	cell redox homeostasis
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0050661	molecular_function	NADP binding
C	0098869	biological_process	cellular oxidant detoxification
D	0000166	molecular_function	nucleotide binding
D	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
D	0005829	cellular_component	cytosol
D	0006749	biological_process	glutathione metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
D	0034599	biological_process	cellular response to oxidative stress
D	0045454	biological_process	cell redox homeostasis
D	0050660	molecular_function	flavin adenine dinucleotide binding
D	0050661	molecular_function	NADP binding
D	0098869	biological_process	cellular oxidant detoxification
E	0000166	molecular_function	nucleotide binding
E	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
E	0005829	cellular_component	cytosol
E	0006749	biological_process	glutathione metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
E	0034599	biological_process	cellular response to oxidative stress
E	0045454	biological_process	cell redox homeostasis
E	0050660	molecular_function	flavin adenine dinucleotide binding
E	0050661	molecular_function	NADP binding
E	0098869	biological_process	cellular oxidant detoxification
F	0000166	molecular_function	nucleotide binding
F	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
F	0005829	cellular_component	cytosol
F	0006749	biological_process	glutathione metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
F	0034599	biological_process	cellular response to oxidative stress
F	0045454	biological_process	cell redox homeostasis
F	0050660	molecular_function	flavin adenine dinucleotide binding
F	0050661	molecular_function	NADP binding
F	0098869	biological_process	cellular oxidant detoxification
G	0000166	molecular_function	nucleotide binding
G	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
G	0005829	cellular_component	cytosol
G	0006749	biological_process	glutathione metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
G	0034599	biological_process	cellular response to oxidative stress
G	0045454	biological_process	cell redox homeostasis
G	0050660	molecular_function	flavin adenine dinucleotide binding
G	0050661	molecular_function	NADP binding
G	0098869	biological_process	cellular oxidant detoxification
H	0000166	molecular_function	nucleotide binding
H	0004362	molecular_function	glutathione-disulfide reductase (NADPH) activity
H	0005829	cellular_component	cytosol
H	0006749	biological_process	glutathione metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016668	molecular_function	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
H	0034599	biological_process	cellular response to oxidative stress
H	0045454	biological_process	cell redox homeostasis
H	0050660	molecular_function	flavin adenine dinucleotide binding
H	0050661	molecular_function	NADP binding
H	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	36
Details	binding site for residue FAD A 501

Chain	Residue
A	GLY10
A	CYS41
A	GLY45
A	CYS46
A	LYS49
A	GLY112
A	HIS113
A	ALA114
A	ALA137
A	THR138
A	GLY139
A	GLY12
A	TYR176
A	ARG261
A	LEU268
A	GLY300
A	ASP301
A	GLU307
A	LEU308
A	THR309
A	PRO310
A	HOH612
A	SER13
A	HOH623
A	HOH648
A	HOH651
A	HOH685
A	HOH696
F	HIS437
F	PRO438
A	GLY14
A	ILE32
A	GLU33
A	GLU34
A	GLY39
A	THR40

site_id	AC2
Number of Residues	37
Details	binding site for residue FAD B 501

Chain	Residue
B	GLY10
B	GLY12
B	SER13
B	GLY14
B	GLU33
B	GLU34
B	LYS35
B	GLY39
B	THR40
B	CYS41
B	GLY45
B	CYS46
B	LYS49
B	GLY112
B	HIS113
B	ALA114
B	ALA137
B	THR138
B	GLY139
B	TYR176
B	ARG261
B	LEU268
B	GLY300
B	ASP301
B	GLU307
B	LEU308
B	THR309
B	PRO310
B	HOH640
B	HOH646
B	HOH659
B	HOH668
B	HOH751
C	HIS437
C	PRO438
C	HOH618
C	HOH664

site_id	AC3
Number of Residues	6
Details	binding site for residue SCN B 502

Chain	Residue
B	TYR288
B	ALA315
B	THR318
B	LEU319
B	ARG322
B	ALA330

site_id	AC4
Number of Residues	34
Details	binding site for residue FAD C 501

Chain	Residue
C	GLY139
C	TYR176
C	ARG261
C	LEU268
C	GLY300
C	ASP301
C	GLU307
C	LEU308
C	THR309
C	PRO310
C	HOH614
C	HOH630
C	HOH655
C	HOH658
B	HIS437
B	PRO438
B	HOH693
C	GLY10
C	GLY12
C	SER13
C	GLY14
C	GLU33
C	GLU34
C	GLY39
C	THR40
C	CYS41
C	GLY45
C	CYS46
C	LYS49
C	GLY112
C	HIS113
C	ALA114
C	ALA137
C	THR138

site_id	AC5
Number of Residues	34
Details	binding site for residue FAD D 501

Chain	Residue
D	ILE9
D	GLY10
D	GLY12
D	SER13
D	GLY14
D	GLU33
D	GLU34
D	LYS35
D	GLY39
D	THR40
D	CYS41
D	GLY45
D	CYS46
D	LYS49
D	HIS113
D	ALA114
D	ALA137
D	THR138
D	GLY139
D	TYR176
D	ARG261
D	GLY300
D	ASP301
D	GLU307
D	LEU308
D	THR309
D	PRO310
D	HOH624
D	HOH625
D	HOH633
D	HOH645
D	HOH670
E	HIS437
E	PRO438

site_id	AC6
Number of Residues	36
Details	binding site for residue FAD E 501

Chain	Residue
D	HIS437
D	PRO438
D	HOH651
D	HOH690
E	GLY10
E	GLY12
E	SER13
E	GLY14
E	GLU33
E	GLU34
E	LYS35
E	GLY39
E	THR40
E	CYS41
E	GLY45
E	CYS46
E	LYS49
E	GLY112
E	HIS113
E	ALA114
E	ALA137
E	THR138
E	GLY139
E	TYR176
E	ARG261
E	LEU268
E	GLY300
E	ASP301
E	GLU307
E	LEU308
E	THR309
E	PRO310
E	HOH611
E	HOH645
E	HOH655
E	HOH660

site_id	AC7
Number of Residues	6
Details	binding site for residue SCN E 502

Chain	Residue
E	GLU287
E	GLN289
E	ALA315
E	THR318
E	LEU319
E	MET332

site_id	AC8
Number of Residues	36
Details	binding site for residue FAD F 501

Chain	Residue
A	HIS437
A	PRO438
F	GLY10
F	GLY12
F	SER13
F	GLY14
F	ILE32
F	GLU33
F	GLU34
F	LYS35
F	GLY39
F	THR40
F	CYS41
F	GLY45
F	CYS46
F	LYS49
F	GLY112
F	HIS113
F	ALA114
F	ALA137
F	THR138
F	GLY139
F	TYR176
F	ARG261
F	LEU268
F	GLY300
F	ASP301
F	GLU307
F	LEU308
F	THR309
F	PRO310
F	HOH618
F	HOH629
F	HOH630
F	HOH657
F	HOH699

site_id	AC9
Number of Residues	37
Details	binding site for residue FAD G 501

Chain	Residue
G	GLY10
G	GLY12
G	SER13
G	GLY14
G	ILE32
G	GLU33
G	GLU34
G	LYS35
G	GLY39
G	THR40
G	CYS41
G	GLY45
G	CYS46
G	LYS49
G	GLY112
G	HIS113
G	ALA114
G	ALA137
G	THR138
G	GLY139
G	TYR176
G	ARG261
G	LEU268
G	GLY300
G	ASP301
G	GLU307
G	LEU308
G	THR309
G	PRO310
G	HOH604
G	HOH606
G	HOH627
G	HOH629
G	HOH651
G	HOH685
H	HIS437
H	PRO438

site_id	AD1
Number of Residues	32
Details	binding site for residue FAD H 501

Chain	Residue
G	HIS437
G	PRO438
H	GLY10
H	GLY12
H	SER13
H	GLY14
H	GLU33
H	GLU34
H	LYS35
H	GLY39
H	THR40
H	CYS41
H	GLY45
H	CYS46
H	LYS49
H	HIS113
H	ALA114
H	ALA137
H	THR138
H	GLY139
H	TYR176
H	ARG261
H	LEU268
H	ASP301
H	GLU307
H	LEU308
H	THR309
H	PRO310
H	HOH621
H	HOH631
H	HOH635
H	HOH666

Functional Information from PROSITE/UniProt

site_id	PS00076
Number of Residues	11
Details	PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCVP

Chain	Residue	Details
A	GLY38-PRO48

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)