6DT4
1.8 Angstrom Resolution Crystal Structure of cAMP-Regulatory Protein from Yersinia pestis in Complex with cAMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0032993 | cellular_component | protein-DNA complex |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0030552 | molecular_function | cAMP binding |
| B | 0032993 | cellular_component | protein-DNA complex |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue CMP A 301 |
| Chain | Residue |
| A | VAL50 |
| A | SER84 |
| A | ALA85 |
| A | ARG124 |
| A | THR128 |
| A | HOH446 |
| A | HOH469 |
| A | HOH472 |
| B | LEU125 |
| B | SER129 |
| A | LEU62 |
| A | SER63 |
| A | ILE71 |
| A | GLY72 |
| A | GLU73 |
| A | LEU74 |
| A | GLY75 |
| A | ARG83 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | HIS32 |
| A | GLU35 |
| A | HOH456 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 303 |
| Chain | Residue |
| A | THR169 |
| A | ARG170 |
| A | ARG181 |
| A | LYS202 |
| A | HOH476 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | TRP14 |
| A | VAL109 |
| A | ASP139 |
| A | VAL140 |
| A | HOH543 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue CMP B 301 |
| Chain | Residue |
| A | LEU125 |
| A | SER129 |
| A | HOH458 |
| B | ILE31 |
| B | VAL50 |
| B | LEU62 |
| B | SER63 |
| B | ILE71 |
| B | GLY72 |
| B | GLU73 |
| B | LEU74 |
| B | ARG83 |
| B | SER84 |
| B | ALA85 |
| B | VAL87 |
| B | ARG124 |
| B | THR128 |
| B | HOH465 |
| B | HOH469 |
Functional Information from PROSITE/UniProt
| site_id | PS00042 |
| Number of Residues | 24 |
| Details | HTH_CRP_1 Crp-type HTH domain signature. ITRqeIGqIVGcSreTv.GRiLkmL |
| Chain | Residue | Details |
| A | ILE168-LEU191 |
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. LIhQGEkAEtLYYIvkG |
| Chain | Residue | Details |
| A | LEU30-GLY46 |
| site_id | PS00889 |
| Number of Residues | 19 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. IGElGLfeegqe.....RSAwVrA |
| Chain | Residue | Details |
| A | ILE71-ALA89 |
