Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6DRV

Beta-galactosidase

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0003824molecular_functioncatalytic activity
A0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
A0004565molecular_functionbeta-galactosidase activity
A0005975biological_processcarbohydrate metabolic process
A0005990biological_processlactose catabolic process
A0009341cellular_componentbeta-galactosidase complex
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0030246molecular_functioncarbohydrate binding
A0031420molecular_functionalkali metal ion binding
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
B0000287molecular_functionmagnesium ion binding
B0003824molecular_functioncatalytic activity
B0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
B0004565molecular_functionbeta-galactosidase activity
B0005975biological_processcarbohydrate metabolic process
B0005990biological_processlactose catabolic process
B0009341cellular_componentbeta-galactosidase complex
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0030246molecular_functioncarbohydrate binding
B0031420molecular_functionalkali metal ion binding
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
C0000287molecular_functionmagnesium ion binding
C0003824molecular_functioncatalytic activity
C0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
C0004565molecular_functionbeta-galactosidase activity
C0005975biological_processcarbohydrate metabolic process
C0005990biological_processlactose catabolic process
C0009341cellular_componentbeta-galactosidase complex
C0016798molecular_functionhydrolase activity, acting on glycosyl bonds
C0030246molecular_functioncarbohydrate binding
C0031420molecular_functionalkali metal ion binding
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
D0000287molecular_functionmagnesium ion binding
D0003824molecular_functioncatalytic activity
D0004553molecular_functionhydrolase activity, hydrolyzing O-glycosyl compounds
D0004565molecular_functionbeta-galactosidase activity
D0005975biological_processcarbohydrate metabolic process
D0005990biological_processlactose catabolic process
D0009341cellular_componentbeta-galactosidase complex
D0016798molecular_functionhydrolase activity, acting on glycosyl bonds
D0030246molecular_functioncarbohydrate binding
D0031420molecular_functionalkali metal ion binding
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
Functional Information from PROSITE/UniProt
site_idPS00608
Number of Residues15
DetailsGLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE
ChainResidueDetails
AASP448-GLU462

site_idPS00719
Number of Residues26
DetailsGLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV
ChainResidueDetails
AASN386-VAL411

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:6420154
ChainResidueDetails
AGLU462
BGLU462
CGLU462
DGLU462

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:1350782
ChainResidueDetails
AGLU538
BGLU538
CGLU538
DGLU538

site_idSWS_FT_FI3
Number of Residues28
DetailsBINDING:
ChainResidueDetails
AASN103
BGLU462
BGLU538
BPHE602
BASN605
BTRP1000
CASN103
CASP202
CGLU462
CGLU538
CPHE602
AASP202
CASN605
CTRP1000
DASN103
DASP202
DGLU462
DGLU538
DPHE602
DASN605
DTRP1000
AGLU462
AGLU538
APHE602
AASN605
ATRP1000
BASN103
BASP202

site_idSWS_FT_FI4
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:11045615
ChainResidueDetails
AGLU417
DGLU417
DHIS419
DASN598
AHIS419
AASN598
BGLU417
BHIS419
BASN598
CGLU417
CHIS419
CASN598

site_idSWS_FT_FI5
Number of Residues8
DetailsSITE: Transition state stabilizer
ChainResidueDetails
AHIS358
AHIS392
BHIS358
BHIS392
CHIS358
CHIS392
DHIS358
DHIS392

site_idSWS_FT_FI6
Number of Residues4
DetailsSITE: Important for ensuring that an appropriate proportion of lactose is converted to allolactose
ChainResidueDetails
ATRP1000
BTRP1000
CTRP1000
DTRP1000

Catalytic Information from CSA
site_idMCSA1
Number of Residues10
DetailsM-CSA 422
ChainResidueDetails
AASP202
AASN605
AHIS358
AHIS392
AGLU417
AHIS419
AGLU462
AGLU538
AASN598
APHE602

site_idMCSA2
Number of Residues10
DetailsM-CSA 422
ChainResidueDetails
BASP202
BASN605
BHIS358
BHIS392
BGLU417
BHIS419
BGLU462
BGLU538
BASN598
BPHE602

site_idMCSA3
Number of Residues10
DetailsM-CSA 422
ChainResidueDetails
CASP202
CASN605
CHIS358
CHIS392
CGLU417
CHIS419
CGLU462
CGLU538
CASN598
CPHE602

site_idMCSA4
Number of Residues10
DetailsM-CSA 422
ChainResidueDetails
DASP202
DASN605
DHIS358
DHIS392
DGLU417
DHIS419
DGLU462
DGLU538
DASN598
DPHE602

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon