6DRJ
Structure of TRPM2 ion channel receptor by single particle electron cryo-microscopy, ADPR/Ca2+ bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0019722 | biological_process | calcium-mediated signaling |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0072570 | molecular_function | ADP-D-ribose binding |
| A | 0072571 | molecular_function | mono-ADP-D-ribose binding |
| A | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
| A | 0099604 | molecular_function | ligand-gated calcium channel activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0019722 | biological_process | calcium-mediated signaling |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0072570 | molecular_function | ADP-D-ribose binding |
| B | 0072571 | molecular_function | mono-ADP-D-ribose binding |
| B | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
| B | 0099604 | molecular_function | ligand-gated calcium channel activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0019722 | biological_process | calcium-mediated signaling |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0072570 | molecular_function | ADP-D-ribose binding |
| C | 0072571 | molecular_function | mono-ADP-D-ribose binding |
| C | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
| C | 0099604 | molecular_function | ligand-gated calcium channel activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0019722 | biological_process | calcium-mediated signaling |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
| D | 0051289 | biological_process | protein homotetramerization |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0072570 | molecular_function | ADP-D-ribose binding |
| D | 0072571 | molecular_function | mono-ADP-D-ribose binding |
| D | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
| D | 0099604 | molecular_function | ligand-gated calcium channel activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue APR A 2001 |
| Chain | Residue |
| A | THR150 |
| A | GLY309 |
| A | PRO310 |
| A | GLY311 |
| A | THR312 |
| A | ARG334 |
| A | GLY151 |
| A | GLY152 |
| A | ALA153 |
| A | LYS154 |
| A | ASN155 |
| A | THR186 |
| A | TYR271 |
| A | ARG278 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 2002 |
| Chain | Residue |
| A | GLU857 |
| A | GLN860 |
| A | ASN883 |
| A | ASP886 |
| A | GLU1088 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue APR B 2001 |
| Chain | Residue |
| B | THR150 |
| B | GLY151 |
| B | GLY152 |
| B | ALA153 |
| B | LYS154 |
| B | ASN155 |
| B | THR186 |
| B | TYR271 |
| B | ARG278 |
| B | GLY309 |
| B | PRO310 |
| B | GLY311 |
| B | THR312 |
| B | ARG334 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 2002 |
| Chain | Residue |
| B | GLU857 |
| B | GLN860 |
| B | ASN883 |
| B | ASP886 |
| B | GLU1088 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue APR C 2001 |
| Chain | Residue |
| C | THR150 |
| C | GLY151 |
| C | GLY152 |
| C | ALA153 |
| C | LYS154 |
| C | ASN155 |
| C | THR186 |
| C | TYR271 |
| C | ARG278 |
| C | GLY309 |
| C | PRO310 |
| C | GLY311 |
| C | THR312 |
| C | ARG334 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 2002 |
| Chain | Residue |
| C | GLU857 |
| C | GLN860 |
| C | ASN883 |
| C | ASP886 |
| C | GLU1088 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residue APR D 2001 |
| Chain | Residue |
| D | THR150 |
| D | GLY151 |
| D | GLY152 |
| D | ALA153 |
| D | LYS154 |
| D | ASN155 |
| D | THR186 |
| D | TYR271 |
| D | ARG278 |
| D | GLY309 |
| D | PRO310 |
| D | GLY311 |
| D | THR312 |
| D | ARG334 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 2002 |
| Chain | Residue |
| D | GLU857 |
| D | GLN860 |
| D | ASN883 |
| D | ASP886 |
| D | GLU1088 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 116 |
| Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:30250252 |
| Chain | Residue | Details |
| A | LYS730-TYR742 | |
| A | PRO1093-ARG1110 | |
| B | LYS730-TYR742 | |
| B | PRO1093-ARG1110 | |
| C | LYS730-TYR742 | |
| C | PRO1093-ARG1110 | |
| D | LYS730-TYR742 | |
| D | PRO1093-ARG1110 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1968 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| A | THR743-PHE813 | |
| C | THR743-PHE813 | |
| C | HIS863-LEU881 | |
| C | ILE932-MET946 | |
| C | TYR1065-ARG1092 | |
| D | THR743-PHE813 | |
| D | HIS863-LEU881 | |
| D | ILE932-MET946 | |
| D | TYR1065-ARG1092 | |
| A | HIS863-LEU881 | |
| A | ILE932-MET946 | |
| A | TYR1065-ARG1092 | |
| B | THR743-PHE813 | |
| B | HIS863-LEU881 | |
| B | ILE932-MET946 | |
| B | TYR1065-ARG1092 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 520 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:30250252 |
| Chain | Residue | Details |
| A | TYR814-ASP834 | |
| B | GLY911-SER931 | |
| B | MET947-ILE973 | |
| B | THR1040-ASN1064 | |
| C | TYR814-ASP834 | |
| C | ARG842-TYR862 | |
| C | TRP882-GLN902 | |
| C | GLY911-SER931 | |
| C | MET947-ILE973 | |
| C | THR1040-ASN1064 | |
| D | TYR814-ASP834 | |
| A | ARG842-TYR862 | |
| D | ARG842-TYR862 | |
| D | TRP882-GLN902 | |
| D | GLY911-SER931 | |
| D | MET947-ILE973 | |
| D | THR1040-ASN1064 | |
| A | TRP882-GLN902 | |
| A | GLY911-SER931 | |
| A | MET947-ILE973 | |
| A | THR1040-ASN1064 | |
| B | TYR814-ASP834 | |
| B | ARG842-TYR862 | |
| B | TRP882-GLN902 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 208 |
| Details | TOPO_DOM: Extracellular => ECO:0000305 |
| Chain | Residue | Details |
| A | PHE835-TRP841 | |
| C | ALA903-ILE910 | |
| C | GLU974-ILE982 | |
| C | ASP1008-LEU1039 | |
| D | PHE835-TRP841 | |
| D | ALA903-ILE910 | |
| D | GLU974-ILE982 | |
| D | ASP1008-LEU1039 | |
| A | ALA903-ILE910 | |
| A | GLU974-ILE982 | |
| A | ASP1008-LEU1039 | |
| B | PHE835-TRP841 | |
| B | ALA903-ILE910 | |
| B | GLU974-ILE982 | |
| B | ASP1008-LEU1039 | |
| C | PHE835-TRP841 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 96 |
| Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:30250252 |
| Chain | Residue | Details |
| A | ILE983-PHE1007 | |
| B | ILE983-PHE1007 | |
| C | ILE983-PHE1007 | |
| D | ILE983-PHE1007 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:30250252 |
| Chain | Residue | Details |
| A | TYR271 | |
| B | ARG278 | |
| B | GLY309 | |
| B | ARG334 | |
| B | ILE858 | |
| B | LEU861 | |
| B | ILE884 | |
| B | TYR1089 | |
| C | TYR271 | |
| C | ARG278 | |
| C | GLY309 | |
| A | ARG278 | |
| C | ARG334 | |
| C | ILE858 | |
| C | LEU861 | |
| C | ILE884 | |
| C | TYR1089 | |
| D | TYR271 | |
| D | ARG278 | |
| D | GLY309 | |
| D | ARG334 | |
| D | ILE858 | |
| A | GLY309 | |
| D | LEU861 | |
| D | ILE884 | |
| D | TYR1089 | |
| A | ARG334 | |
| A | ILE858 | |
| A | LEU861 | |
| A | ILE884 | |
| A | TYR1089 | |
| B | TYR271 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ALA1016 | |
| B | ALA1016 | |
| C | ALA1016 | |
| D | ALA1016 |
