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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6DRC

High IP3 Ca2+ human type 3 1,4,5-inositol trisphosphate receptor

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000822molecular_functioninositol hexakisphosphate binding
A0005216molecular_functionmonoatomic ion channel activity
A0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008270molecular_functionzinc ion binding
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030168biological_processplatelet activation
A0030658cellular_componenttransport vesicle membrane
A0030667cellular_componentsecretory granule membrane
A0031095cellular_componentplatelet dense tubular network membrane
A0035091molecular_functionphosphatidylinositol binding
A0043025cellular_componentneuronal cell body
A0043235cellular_componentreceptor complex
A0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
A0045177cellular_componentapical part of cell
A0050909biological_processsensory perception of taste
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051289biological_processprotein homotetramerization
A0051592biological_processresponse to calcium ion
A0055074biological_processcalcium ion homeostasis
A0055085biological_processtransmembrane transport
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
A0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
B0000822molecular_functioninositol hexakisphosphate binding
B0005216molecular_functionmonoatomic ion channel activity
B0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007186biological_processG protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008270molecular_functionzinc ion binding
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030168biological_processplatelet activation
B0030658cellular_componenttransport vesicle membrane
B0030667cellular_componentsecretory granule membrane
B0031095cellular_componentplatelet dense tubular network membrane
B0035091molecular_functionphosphatidylinositol binding
B0043025cellular_componentneuronal cell body
B0043235cellular_componentreceptor complex
B0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
B0045177cellular_componentapical part of cell
B0050909biological_processsensory perception of taste
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051289biological_processprotein homotetramerization
B0051592biological_processresponse to calcium ion
B0055074biological_processcalcium ion homeostasis
B0055085biological_processtransmembrane transport
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
B0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
C0000822molecular_functioninositol hexakisphosphate binding
C0005216molecular_functionmonoatomic ion channel activity
C0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005640cellular_componentnuclear outer membrane
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007186biological_processG protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008270molecular_functionzinc ion binding
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030168biological_processplatelet activation
C0030658cellular_componenttransport vesicle membrane
C0030667cellular_componentsecretory granule membrane
C0031095cellular_componentplatelet dense tubular network membrane
C0035091molecular_functionphosphatidylinositol binding
C0043025cellular_componentneuronal cell body
C0043235cellular_componentreceptor complex
C0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
C0045177cellular_componentapical part of cell
C0050909biological_processsensory perception of taste
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051289biological_processprotein homotetramerization
C0051592biological_processresponse to calcium ion
C0055074biological_processcalcium ion homeostasis
C0055085biological_processtransmembrane transport
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
D0000822molecular_functioninositol hexakisphosphate binding
D0005216molecular_functionmonoatomic ion channel activity
D0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005640cellular_componentnuclear outer membrane
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007186biological_processG protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008270molecular_functionzinc ion binding
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0030168biological_processplatelet activation
D0030658cellular_componenttransport vesicle membrane
D0030667cellular_componentsecretory granule membrane
D0031095cellular_componentplatelet dense tubular network membrane
D0035091molecular_functionphosphatidylinositol binding
D0043025cellular_componentneuronal cell body
D0043235cellular_componentreceptor complex
D0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
D0045177cellular_componentapical part of cell
D0050909biological_processsensory perception of taste
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051289biological_processprotein homotetramerization
D0051592biological_processresponse to calcium ion
D0055074biological_processcalcium ion homeostasis
D0055085biological_processtransmembrane transport
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 3001
ChainResidue
ACYS2538
ACYS2541
AHIS2558
AHIS2563
site_idAC2
Number of Residues8
Detailsbinding site for residue I3P A 3002
ChainResidue
ATYR567
AARG568
ALYS569
AARG266
ATHR267
ATHR268
ALYS507
AARG510
site_idAC3
Number of Residues2
Detailsbinding site for residue CA A 3003
ChainResidue
AGLU1946
ATHR2581
site_idAC4
Number of Residues3
Detailsbinding site for residue CA A 3004
ChainResidue
AARG743
AGLU1122
AGLU1125
site_idAC5
Number of Residues4
Detailsbinding site for residue ZN B 3001
ChainResidue
BCYS2538
BCYS2541
BHIS2558
BHIS2563
site_idAC6
Number of Residues8
Detailsbinding site for residue I3P B 3002
ChainResidue
BARG266
BTHR267
BTHR268
BLYS507
BARG510
BTYR567
BARG568
BLYS569
site_idAC7
Number of Residues2
Detailsbinding site for residue CA B 3003
ChainResidue
BGLU1946
BTHR2581
site_idAC8
Number of Residues3
Detailsbinding site for residue CA B 3004
ChainResidue
BARG743
BGLU1122
BGLU1125
site_idAC9
Number of Residues4
Detailsbinding site for residue ZN C 3001
ChainResidue
CCYS2538
CCYS2541
CHIS2558
CHIS2563
site_idAD1
Number of Residues8
Detailsbinding site for residue I3P C 3002
ChainResidue
CARG266
CTHR267
CTHR268
CLYS507
CARG510
CTYR567
CARG568
CLYS569
site_idAD2
Number of Residues2
Detailsbinding site for residue CA C 3003
ChainResidue
CGLU1946
CTHR2581
site_idAD3
Number of Residues3
Detailsbinding site for residue CA C 3004
ChainResidue
CARG743
CGLU1122
CGLU1125
site_idAD4
Number of Residues4
Detailsbinding site for residue ZN D 3001
ChainResidue
DCYS2538
DCYS2541
DHIS2558
DHIS2563
site_idAD5
Number of Residues8
Detailsbinding site for residue I3P D 3002
ChainResidue
DARG266
DTHR267
DTHR268
DLYS507
DARG510
DTYR567
DARG568
DLYS569
site_idAD6
Number of Residues2
Detailsbinding site for residue CA D 3003
ChainResidue
DGLU1946
DTHR2581
site_idAD7
Number of Residues3
Detailsbinding site for residue CA D 3004
ChainResidue
DARG743
DGLU1122
DGLU1125
Functional Information from PROSITE/UniProt
site_idPS00307
Number of Residues7
DetailsLECTIN_LEGUME_BETA Legume lectins beta-chain signature. LSVVLDT
ChainResidueDetails
ALEU1443-THR1449
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues400
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues112
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues156
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues240
DetailsDomain: {"description":"MIR 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues200
DetailsDomain: {"description":"MIR 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues224
DetailsDomain: {"description":"MIR 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues224
DetailsDomain: {"description":"MIR 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00131","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DQZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6DQZ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DQN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TKF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DRA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DRA","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DR2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TKG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TL9","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3R","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TKG","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"30013099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DR0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TKD","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TKG","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7T3R","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35301323","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37898605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8TKI","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

251422

PDB entries from 2026-04-01

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