6DR4

X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36 containing the I31V point mutation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue HEZ B 101

Chain	Residue
A	GLU7
B	VAL3
B	ORN15
D	ORN1
D	VAL3
D	GLU7
D	ORN15

---

site_id	AC2
Number of Residues	8
Details	binding site for residue HEZ B 102

Chain	Residue
A	ORN15
B	GLU7
C	ORN1
C	VAL3
C	GLU7
C	ORN15
A	ORN1
A	VAL3

---

site_id	AC3
Number of Residues	2
Details	binding site for residue HEZ B 103

Chain	Residue
B	VAL16
B	HOH202

---

site_id	AC4
Number of Residues	7
Details	binding site for Di-peptide ORN B 1 and VAL B 16

Chain	Residue
A	CYS6
A	GLU7
B	CYS2
B	LEU14
B	ORN15
B	HEZ103
C	VAL16

---

site_id	AC5
Number of Residues	7
Details	binding site for Di-peptide ORN B 1 and CYS B 2

Chain	Residue
A	MEA5
A	CYS6
A	GLU7
B	VAL3
B	LEU14
B	ORN15
B	VAL16

---

site_id	AC6
Number of Residues	7
Details	binding site for Di-peptide PHE B 4 and MEA B 5

Chain	Residue
B	VAL3
B	CYS6
B	ILE12
B	GLY13
B	LEU14
C	CYS2
C	VAL3

---

site_id	AC7
Number of Residues	8
Details	binding site for Di-peptide MEA B 5 and CYS B 6

Chain	Residue
B	PHE4
B	GLU7
B	VAL11
B	ILE12
C	ORN1
C	CYS2
C	VAL3
C	VAL16

---

site_id	AC8
Number of Residues	5
Details	binding site for Di-peptide ASP B 8 and ORN B 9

Chain	Residue
B	GLU7
B	ALA10
B	VAL11
B	HOH201
C	HOH101

---

site_id	AC9
Number of Residues	5
Details	binding site for Di-peptide ORN B 9 and ALA B 10

Chain	Residue
A	ILE12
A	GLY13
B	GLU7
B	ASP8
B	VAL11

---

site_id	AD1
Number of Residues	12
Details	binding site for Di-peptide LEU B 14 and ORN B 15

Chain	Residue
A	HOH103
B	CYS2
B	VAL3
B	PHE4
B	ILE12
B	GLY13
B	VAL16
B	HEZ101
C	ORN1
C	VAL16
D	GLU7
D	ORN9

---

site_id	AD2
Number of Residues	9
Details	binding site for Di-peptide ORN B 15 and VAL B 16

Chain	Residue
A	HOH103
B	ORN1
B	CYS2
B	LEU14
B	HEZ101
B	HEZ103
C	VAL16
D	GLU7
D	ORN9

---

site_id	AD3
Number of Residues	12
Details	binding site for Di-peptide ORN C 1 and CYS C 2

Chain	Residue
B	MEA5
B	CYS6
B	GLU7
B	GLU7
B	LEU14
B	HEZ102
C	VAL3
C	LEU14
C	ORN15
C	VAL16
C	VAL16
C	HOH104

---

site_id	AD4
Number of Residues	13
Details	binding site for Di-peptide ORN C 1 and VAL C 16

Chain	Residue
C	LEU14
C	ORN15
C	HOH104
B	CYS6
B	CYS6
B	GLU7
B	GLU7
B	LEU14
B	VAL16
B	HEZ102
C	CYS2
C	CYS2
C	PHE4

---

site_id	AD5
Number of Residues	8
Details	binding site for Di-peptide PHE C 4 and MEA C 5

Chain	Residue
A	CYS2
A	VAL3
C	VAL3
C	CYS6
C	ILE12
C	GLY13
C	LEU14
C	VAL16

---

site_id	AD6
Number of Residues	8
Details	binding site for Di-peptide MEA C 5 and CYS C 6

Chain	Residue
A	ORN1
A	CYS2
A	VAL3
C	PHE4
C	GLU7
C	VAL11
C	ILE12
C	GLY13

---

site_id	AD7
Number of Residues	5
Details	binding site for Di-peptide ASP C 8 and ORN C 9

Chain	Residue
C	GLU7
C	ALA10
C	VAL11
C	ORN15
C	HOH103

---

site_id	AD8
Number of Residues	8
Details	binding site for Di-peptide ORN C 9 and ALA C 10

Chain	Residue
C	GLU7
C	ASP8
C	VAL11
C	ILE12
C	GLY13
C	ORN15
C	HOH103
C	HOH105

---

site_id	AD9
Number of Residues	12
Details	binding site for Di-peptide LEU C 14 and ORN C 15

Chain	Residue
B	HEZ102
B	HOH201
C	ORN1
C	CYS2
C	VAL3
C	PHE4
C	GLU7
C	ORN9
C	ILE12
C	GLY13
C	VAL16
C	HOH101

---

site_id	AE1
Number of Residues	13
Details	binding site for Di-peptide ORN C 15 and VAL C 16

Chain	Residue
B	CYS6
B	LEU14
B	VAL16
B	HEZ102
B	HOH201
C	ORN1
C	CYS2
C	CYS2
C	PHE4
C	GLU7
C	ORN9
C	LEU14
C	HOH101

---

site_id	AE2
Number of Residues	11
Details	binding site for Di-peptide ORN D 1 and CYS D 2

Chain	Residue
B	HEZ101
D	VAL3
D	PHE4
D	MEA5
D	CYS6
D	GLU7
D	GLU7
D	LEU14
D	ORN15
D	VAL16
D	VAL16

---

site_id	AE3
Number of Residues	10
Details	binding site for Di-peptide ORN D 1 and VAL D 16

Chain	Residue
B	HEZ101
D	CYS2
D	CYS2
D	CYS6
D	CYS6
D	GLU7
D	GLU7
D	LEU14
D	LEU14
D	ORN15

---

site_id	AE4
Number of Residues	8
Details	binding site for Di-peptide PHE D 4 and MEA D 5

Chain	Residue
D	CYS2
D	CYS2
D	VAL3
D	VAL3
D	CYS6
D	ILE12
D	GLY13
D	LEU14

---

site_id	AE5
Number of Residues	10
Details	binding site for Di-peptide MEA D 5 and CYS D 6

Chain	Residue
D	ORN1
D	CYS2
D	VAL3
D	PHE4
D	GLU7
D	ALA10
D	VAL11
D	ILE12
D	GLY13
D	VAL16

---

site_id	AE6
Number of Residues	5
Details	binding site for Di-peptide ASP D 8 and ORN D 9

Chain	Residue
B	ORN15
D	GLU7
D	ALA10
D	VAL11
D	HOH102

---

site_id	AE7
Number of Residues	8
Details	binding site for Di-peptide ORN D 9 and ALA D 10

Chain	Residue
B	GLY13
B	ORN15
D	CYS6
D	GLU7
D	ASP8
D	VAL11
D	HOH102
D	HOH103

---

site_id	AE8
Number of Residues	11
Details	binding site for Di-peptide LEU D 14 and ORN D 15

Chain	Residue
A	ORN9
A	HOH103
B	HEZ101
D	CYS2
D	VAL3
D	PHE4
D	ILE12
D	GLY13
D	VAL16
D	VAL16
D	HOH101

---

site_id	AE9
Number of Residues	10
Details	binding site for Di-peptide ORN D 15 and VAL D 16

Chain	Residue
A	ORN9
A	HOH103
B	HEZ101
D	ORN1
D	CYS2
D	CYS2
D	CYS6
D	LEU14
D	LEU14
D	HOH101

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