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6DR0

Class 5 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000822molecular_functioninositol hexakisphosphate binding
A0005216molecular_functionmonoatomic ion channel activity
A0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
A0005262molecular_functioncalcium channel activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005640cellular_componentnuclear outer membrane
A0005654cellular_componentnucleoplasm
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0005903cellular_componentbrush border
A0006811biological_processmonoatomic ion transport
A0006816biological_processcalcium ion transport
A0007186biological_processG protein-coupled receptor signaling pathway
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0007613biological_processmemory
A0012505cellular_componentendomembrane system
A0015278molecular_functionintracellularly gated calcium channel activity
A0016020cellular_componentmembrane
A0016529cellular_componentsarcoplasmic reticulum
A0019722biological_processcalcium-mediated signaling
A0030667cellular_componentsecretory granule membrane
A0031095cellular_componentplatelet dense tubular network membrane
A0034220biological_processmonoatomic ion transmembrane transport
A0035091molecular_functionphosphatidylinositol binding
A0043025cellular_componentneuronal cell body
A0043209cellular_componentmyelin sheath
A0043231cellular_componentintracellular membrane-bounded organelle
A0043235cellular_componentreceptor complex
A0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
A0045177cellular_componentapical part of cell
A0050909biological_processsensory perception of taste
A0050913biological_processsensory perception of bitter taste
A0050916biological_processsensory perception of sweet taste
A0050917biological_processsensory perception of umami taste
A0051209biological_processrelease of sequestered calcium ion into cytosol
A0051592biological_processresponse to calcium ion
A0055074biological_processcalcium ion homeostasis
A0055085biological_processtransmembrane transport
A0060291biological_processlong-term synaptic potentiation
A0070588biological_processcalcium ion transmembrane transport
A0070679molecular_functioninositol 1,4,5 trisphosphate binding
A0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
B0000822molecular_functioninositol hexakisphosphate binding
B0005216molecular_functionmonoatomic ion channel activity
B0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
B0005262molecular_functioncalcium channel activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005640cellular_componentnuclear outer membrane
B0005654cellular_componentnucleoplasm
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0005903cellular_componentbrush border
B0006811biological_processmonoatomic ion transport
B0006816biological_processcalcium ion transport
B0007186biological_processG protein-coupled receptor signaling pathway
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0007613biological_processmemory
B0012505cellular_componentendomembrane system
B0015278molecular_functionintracellularly gated calcium channel activity
B0016020cellular_componentmembrane
B0016529cellular_componentsarcoplasmic reticulum
B0019722biological_processcalcium-mediated signaling
B0030667cellular_componentsecretory granule membrane
B0031095cellular_componentplatelet dense tubular network membrane
B0034220biological_processmonoatomic ion transmembrane transport
B0035091molecular_functionphosphatidylinositol binding
B0043025cellular_componentneuronal cell body
B0043209cellular_componentmyelin sheath
B0043231cellular_componentintracellular membrane-bounded organelle
B0043235cellular_componentreceptor complex
B0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
B0045177cellular_componentapical part of cell
B0050909biological_processsensory perception of taste
B0050913biological_processsensory perception of bitter taste
B0050916biological_processsensory perception of sweet taste
B0050917biological_processsensory perception of umami taste
B0051209biological_processrelease of sequestered calcium ion into cytosol
B0051592biological_processresponse to calcium ion
B0055074biological_processcalcium ion homeostasis
B0055085biological_processtransmembrane transport
B0060291biological_processlong-term synaptic potentiation
B0070588biological_processcalcium ion transmembrane transport
B0070679molecular_functioninositol 1,4,5 trisphosphate binding
B0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
C0000822molecular_functioninositol hexakisphosphate binding
C0005216molecular_functionmonoatomic ion channel activity
C0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
C0005262molecular_functioncalcium channel activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005640cellular_componentnuclear outer membrane
C0005654cellular_componentnucleoplasm
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0005903cellular_componentbrush border
C0006811biological_processmonoatomic ion transport
C0006816biological_processcalcium ion transport
C0007186biological_processG protein-coupled receptor signaling pathway
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0007613biological_processmemory
C0012505cellular_componentendomembrane system
C0015278molecular_functionintracellularly gated calcium channel activity
C0016020cellular_componentmembrane
C0016529cellular_componentsarcoplasmic reticulum
C0019722biological_processcalcium-mediated signaling
C0030667cellular_componentsecretory granule membrane
C0031095cellular_componentplatelet dense tubular network membrane
C0034220biological_processmonoatomic ion transmembrane transport
C0035091molecular_functionphosphatidylinositol binding
C0043025cellular_componentneuronal cell body
C0043209cellular_componentmyelin sheath
C0043231cellular_componentintracellular membrane-bounded organelle
C0043235cellular_componentreceptor complex
C0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
C0045177cellular_componentapical part of cell
C0050909biological_processsensory perception of taste
C0050913biological_processsensory perception of bitter taste
C0050916biological_processsensory perception of sweet taste
C0050917biological_processsensory perception of umami taste
C0051209biological_processrelease of sequestered calcium ion into cytosol
C0051592biological_processresponse to calcium ion
C0055074biological_processcalcium ion homeostasis
C0055085biological_processtransmembrane transport
C0060291biological_processlong-term synaptic potentiation
C0070588biological_processcalcium ion transmembrane transport
C0070679molecular_functioninositol 1,4,5 trisphosphate binding
C0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
D0000822molecular_functioninositol hexakisphosphate binding
D0005216molecular_functionmonoatomic ion channel activity
D0005220molecular_functioninositol 1,4,5-trisphosphate-gated calcium channel activity
D0005262molecular_functioncalcium channel activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005640cellular_componentnuclear outer membrane
D0005654cellular_componentnucleoplasm
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005886cellular_componentplasma membrane
D0005903cellular_componentbrush border
D0006811biological_processmonoatomic ion transport
D0006816biological_processcalcium ion transport
D0007186biological_processG protein-coupled receptor signaling pathway
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0007613biological_processmemory
D0012505cellular_componentendomembrane system
D0015278molecular_functionintracellularly gated calcium channel activity
D0016020cellular_componentmembrane
D0016529cellular_componentsarcoplasmic reticulum
D0019722biological_processcalcium-mediated signaling
D0030667cellular_componentsecretory granule membrane
D0031095cellular_componentplatelet dense tubular network membrane
D0034220biological_processmonoatomic ion transmembrane transport
D0035091molecular_functionphosphatidylinositol binding
D0043025cellular_componentneuronal cell body
D0043209cellular_componentmyelin sheath
D0043231cellular_componentintracellular membrane-bounded organelle
D0043235cellular_componentreceptor complex
D0043533molecular_functioninositol 1,3,4,5 tetrakisphosphate binding
D0045177cellular_componentapical part of cell
D0050909biological_processsensory perception of taste
D0050913biological_processsensory perception of bitter taste
D0050916biological_processsensory perception of sweet taste
D0050917biological_processsensory perception of umami taste
D0051209biological_processrelease of sequestered calcium ion into cytosol
D0051592biological_processresponse to calcium ion
D0055074biological_processcalcium ion homeostasis
D0055085biological_processtransmembrane transport
D0060291biological_processlong-term synaptic potentiation
D0070588biological_processcalcium ion transmembrane transport
D0070679molecular_functioninositol 1,4,5 trisphosphate binding
D0098554cellular_componentcytoplasmic side of endoplasmic reticulum membrane
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 2701
ChainResidue
ACYS2538
ACYS2541
AHIS2558
AHIS2563

site_idAC2
Number of Residues8
Detailsbinding site for residue I3P A 2702
ChainResidue
ATYR567
AARG568
ALYS569
AARG266
ATHR268
AARG503
ALYS507
AARG510

site_idAC3
Number of Residues4
Detailsbinding site for residue ZN B 2701
ChainResidue
BCYS2538
BCYS2541
BHIS2558
BHIS2563

site_idAC4
Number of Residues9
Detailsbinding site for residue I3P B 2702
ChainResidue
BARG266
BTHR268
BLEU269
BARG270
BLYS507
BARG510
BTYR567
BARG568
BLYS569

site_idAC5
Number of Residues4
Detailsbinding site for residue ZN C 2701
ChainResidue
CCYS2538
CCYS2541
CHIS2558
CHIS2563

site_idAC6
Number of Residues9
Detailsbinding site for residue I3P C 2702
ChainResidue
CARG266
CTHR268
CLEU269
CARG270
CARG503
CLYS507
CARG510
CARG568
CLYS569

site_idAC7
Number of Residues4
Detailsbinding site for residue ZN D 2701
ChainResidue
DCYS2538
DCYS2541
DHIS2558
DHIS2563

site_idAC8
Number of Residues8
Detailsbinding site for residue I3P D 2702
ChainResidue
DTHR268
DLEU269
DARG503
DLYS507
DARG510
DTYR567
DARG568
DLYS569

Functional Information from PROSITE/UniProt
site_idPS00307
Number of Residues7
DetailsLECTIN_LEGUME_BETA Legume lectins beta-chain signature. LSVVLDT
ChainResidueDetails
ALEU1469-THR1475

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9528
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
AMET1-THR2202
CLYS2250-LEU2264
CASP2347-SER2368
CASP2518-ARG2671
DMET1-THR2202
DLYS2250-LEU2264
DASP2347-SER2368
DASP2518-ARG2671
ALYS2250-LEU2264
AASP2347-SER2368
AASP2518-ARG2671
BMET1-THR2202
BLYS2250-LEU2264
BASP2347-SER2368
BASP2518-ARG2671
CMET1-THR2202

site_idSWS_FT_FI2
Number of Residues480
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ALEU2203-TYR2223
BTYR2326-PHE2346
BILE2369-LEU2389
BASP2497-ILE2517
CLEU2203-TYR2223
CSER2225-THR2249
CILE2265-LEU2285
CTYR2326-PHE2346
CILE2369-LEU2389
CASP2497-ILE2517
DLEU2203-TYR2223
ASER2225-THR2249
DSER2225-THR2249
DILE2265-LEU2285
DTYR2326-PHE2346
DILE2369-LEU2389
DASP2497-ILE2517
AILE2265-LEU2285
ATYR2326-PHE2346
AILE2369-LEU2389
AASP2497-ILE2517
BLEU2203-TYR2223
BSER2225-THR2249
BILE2265-LEU2285

site_idSWS_FT_FI3
Number of Residues624
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
APRO2224-ASP2225
DPRO2224-ASP2225
DGLY2286-GLY2325
DPHE2390-TYR2496
AGLY2286-GLY2325
APHE2390-TYR2496
BPRO2224-ASP2225
BGLY2286-GLY2325
BPHE2390-TYR2496
CPRO2224-ASP2225
CGLY2286-GLY2325
CPHE2390-TYR2496

site_idSWS_FT_FI4
Number of Residues12
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AARG266
DARG266
DLYS507
DTYR567
ALYS507
ATYR567
BARG266
BLYS507
BTYR567
CARG266
CLYS507
CTYR567

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER916
BSER916
CSER916
DSER916

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER934
BSER934
CSER934
DSER934

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
ASER1813
BSER1813
CSER1813
DSER1813

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1832
BSER1832
CSER1832
DSER1832

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1834
ASER2609
BSER1834
BSER2609
CSER1834
CSER2609
DSER1834
DSER2609

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER2670
BSER2670
CSER2670
DSER2670

218853

PDB entries from 2024-04-24

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