Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DQZ

Class 4 IP3-bound human type 3 1,4,5-inositol trisphosphate receptor

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000822	molecular_function	inositol hexakisphosphate binding
A	0005216	molecular_function	monoatomic ion channel activity
A	0005220	molecular_function	inositol 1,4,5-trisphosphate-gated calcium channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005640	cellular_component	nuclear outer membrane
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0005903	cellular_component	brush border
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0007613	biological_process	memory
A	0008324	molecular_function	monoatomic cation transmembrane transporter activity
A	0012505	cellular_component	endomembrane system
A	0015278	molecular_function	intracellularly gated calcium channel activity
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0019722	biological_process	calcium-mediated signaling
A	0030658	cellular_component	transport vesicle membrane
A	0030667	cellular_component	secretory granule membrane
A	0031095	cellular_component	platelet dense tubular network membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0035091	molecular_function	phosphatidylinositol binding
A	0043025	cellular_component	neuronal cell body
A	0043209	cellular_component	myelin sheath
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0043235	cellular_component	receptor complex
A	0043533	molecular_function	inositol 1,3,4,5 tetrakisphosphate binding
A	0045177	cellular_component	apical part of cell
A	0050909	biological_process	sensory perception of taste
A	0050913	biological_process	sensory perception of bitter taste
A	0050916	biological_process	sensory perception of sweet taste
A	0050917	biological_process	sensory perception of umami taste
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051289	biological_process	protein homotetramerization
A	0051592	biological_process	response to calcium ion
A	0055074	biological_process	calcium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0060291	biological_process	long-term synaptic potentiation
A	0070588	biological_process	calcium ion transmembrane transport
A	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
A	0098554	cellular_component	cytoplasmic side of endoplasmic reticulum membrane
B	0000822	molecular_function	inositol hexakisphosphate binding
B	0005216	molecular_function	monoatomic ion channel activity
B	0005220	molecular_function	inositol 1,4,5-trisphosphate-gated calcium channel activity
B	0005262	molecular_function	calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005640	cellular_component	nuclear outer membrane
B	0005654	cellular_component	nucleoplasm
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005886	cellular_component	plasma membrane
B	0005903	cellular_component	brush border
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0007613	biological_process	memory
B	0008324	molecular_function	monoatomic cation transmembrane transporter activity
B	0012505	cellular_component	endomembrane system
B	0015278	molecular_function	intracellularly gated calcium channel activity
B	0016020	cellular_component	membrane
B	0016529	cellular_component	sarcoplasmic reticulum
B	0019722	biological_process	calcium-mediated signaling
B	0030658	cellular_component	transport vesicle membrane
B	0030667	cellular_component	secretory granule membrane
B	0031095	cellular_component	platelet dense tubular network membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0035091	molecular_function	phosphatidylinositol binding
B	0043025	cellular_component	neuronal cell body
B	0043209	cellular_component	myelin sheath
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0043235	cellular_component	receptor complex
B	0043533	molecular_function	inositol 1,3,4,5 tetrakisphosphate binding
B	0045177	cellular_component	apical part of cell
B	0050909	biological_process	sensory perception of taste
B	0050913	biological_process	sensory perception of bitter taste
B	0050916	biological_process	sensory perception of sweet taste
B	0050917	biological_process	sensory perception of umami taste
B	0051209	biological_process	release of sequestered calcium ion into cytosol
B	0051289	biological_process	protein homotetramerization
B	0051592	biological_process	response to calcium ion
B	0055074	biological_process	calcium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0060291	biological_process	long-term synaptic potentiation
B	0070588	biological_process	calcium ion transmembrane transport
B	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
B	0098554	cellular_component	cytoplasmic side of endoplasmic reticulum membrane
C	0000822	molecular_function	inositol hexakisphosphate binding
C	0005216	molecular_function	monoatomic ion channel activity
C	0005220	molecular_function	inositol 1,4,5-trisphosphate-gated calcium channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005640	cellular_component	nuclear outer membrane
C	0005654	cellular_component	nucleoplasm
C	0005730	cellular_component	nucleolus
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005886	cellular_component	plasma membrane
C	0005903	cellular_component	brush border
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
C	0007613	biological_process	memory
C	0008324	molecular_function	monoatomic cation transmembrane transporter activity
C	0012505	cellular_component	endomembrane system
C	0015278	molecular_function	intracellularly gated calcium channel activity
C	0016020	cellular_component	membrane
C	0016529	cellular_component	sarcoplasmic reticulum
C	0019722	biological_process	calcium-mediated signaling
C	0030658	cellular_component	transport vesicle membrane
C	0030667	cellular_component	secretory granule membrane
C	0031095	cellular_component	platelet dense tubular network membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0035091	molecular_function	phosphatidylinositol binding
C	0043025	cellular_component	neuronal cell body
C	0043209	cellular_component	myelin sheath
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0043235	cellular_component	receptor complex
C	0043533	molecular_function	inositol 1,3,4,5 tetrakisphosphate binding
C	0045177	cellular_component	apical part of cell
C	0050909	biological_process	sensory perception of taste
C	0050913	biological_process	sensory perception of bitter taste
C	0050916	biological_process	sensory perception of sweet taste
C	0050917	biological_process	sensory perception of umami taste
C	0051209	biological_process	release of sequestered calcium ion into cytosol
C	0051289	biological_process	protein homotetramerization
C	0051592	biological_process	response to calcium ion
C	0055074	biological_process	calcium ion homeostasis
C	0055085	biological_process	transmembrane transport
C	0060291	biological_process	long-term synaptic potentiation
C	0070588	biological_process	calcium ion transmembrane transport
C	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
C	0098554	cellular_component	cytoplasmic side of endoplasmic reticulum membrane
D	0000822	molecular_function	inositol hexakisphosphate binding
D	0005216	molecular_function	monoatomic ion channel activity
D	0005220	molecular_function	inositol 1,4,5-trisphosphate-gated calcium channel activity
D	0005262	molecular_function	calcium channel activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005640	cellular_component	nuclear outer membrane
D	0005654	cellular_component	nucleoplasm
D	0005730	cellular_component	nucleolus
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005886	cellular_component	plasma membrane
D	0005903	cellular_component	brush border
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
D	0007613	biological_process	memory
D	0008324	molecular_function	monoatomic cation transmembrane transporter activity
D	0012505	cellular_component	endomembrane system
D	0015278	molecular_function	intracellularly gated calcium channel activity
D	0016020	cellular_component	membrane
D	0016529	cellular_component	sarcoplasmic reticulum
D	0019722	biological_process	calcium-mediated signaling
D	0030658	cellular_component	transport vesicle membrane
D	0030667	cellular_component	secretory granule membrane
D	0031095	cellular_component	platelet dense tubular network membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0035091	molecular_function	phosphatidylinositol binding
D	0043025	cellular_component	neuronal cell body
D	0043209	cellular_component	myelin sheath
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0043235	cellular_component	receptor complex
D	0043533	molecular_function	inositol 1,3,4,5 tetrakisphosphate binding
D	0045177	cellular_component	apical part of cell
D	0050909	biological_process	sensory perception of taste
D	0050913	biological_process	sensory perception of bitter taste
D	0050916	biological_process	sensory perception of sweet taste
D	0050917	biological_process	sensory perception of umami taste
D	0051209	biological_process	release of sequestered calcium ion into cytosol
D	0051289	biological_process	protein homotetramerization
D	0051592	biological_process	response to calcium ion
D	0055074	biological_process	calcium ion homeostasis
D	0055085	biological_process	transmembrane transport
D	0060291	biological_process	long-term synaptic potentiation
D	0070588	biological_process	calcium ion transmembrane transport
D	0070679	molecular_function	inositol 1,4,5 trisphosphate binding
D	0098554	cellular_component	cytoplasmic side of endoplasmic reticulum membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 3001

Chain	Residue
A	CYS2538
A	CYS2541
A	HIS2558
A	HIS2563

site_id	AC2
Number of Residues	10
Details	binding site for residue I3P A 3002

Chain	Residue
A	LYS507
A	ARG510
A	TYR567
A	ARG568
A	LYS569
A	ARG266
A	THR268
A	LEU269
A	ARG270
A	ARG503

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 3001

Chain	Residue
B	CYS2538
B	CYS2541
B	HIS2558
B	HIS2563

site_id	AC4
Number of Residues	9
Details	binding site for residue I3P B 3002

Chain	Residue
B	ARG266
B	THR268
B	LEU269
B	ARG270
B	ARG503
B	LYS507
B	TYR567
B	ARG568
B	LYS569

site_id	AC5
Number of Residues	6
Details	binding site for residue ZN D 3001

Chain	Residue
D	CYS2541
D	LEU2543
D	HIS2558
D	HIS2563
D	ARG2606
D	ALA2607

site_id	AC6
Number of Residues	8
Details	binding site for residue I3P D 3002

Chain	Residue
D	ARG266
D	THR268
D	LEU269
D	LYS507
D	ARG510
D	TYR567
D	ARG568
D	LYS569

site_id	AC7
Number of Residues	6
Details	binding site for residue ZN C 3001

Chain	Residue
C	CYS2541
C	LEU2543
C	HIS2558
C	HIS2563
C	ARG2606
C	ALA2607

site_id	AC8
Number of Residues	7
Details	binding site for residue I3P C 3002

Chain	Residue
C	THR268
C	LEU269
C	LYS507
C	ARG510
C	TYR567
C	ARG568
C	LYS569

Functional Information from PROSITE/UniProt

site_id	PS00307
Number of Residues	7
Details	LECTIN_LEGUME_BETA Legume lectins beta-chain signature. LSVVLDT

Chain	Residue	Details
A	LEU1469-THR1475

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9528
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1-THR2202
D	LYS2250-LEU2264
D	ASP2347-SER2368
D	ASP2518-ARG2671
C	MET1-THR2202
C	LYS2250-LEU2264
C	ASP2347-SER2368
C	ASP2518-ARG2671
A	LYS2250-LEU2264
A	ASP2347-SER2368
A	ASP2518-ARG2671
B	MET1-THR2202
B	LYS2250-LEU2264
B	ASP2347-SER2368
B	ASP2518-ARG2671
D	MET1-THR2202

site_id	SWS_FT_FI2
Number of Residues	480
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	LEU2203-TYR2223
B	TYR2326-PHE2346
B	ILE2369-LEU2389
B	ASP2497-ILE2517
D	LEU2203-TYR2223
D	SER2225-THR2249
D	ILE2265-LEU2285
D	TYR2326-PHE2346
D	ILE2369-LEU2389
D	ASP2497-ILE2517
C	LEU2203-TYR2223
A	SER2225-THR2249
C	SER2225-THR2249
C	ILE2265-LEU2285
C	TYR2326-PHE2346
C	ILE2369-LEU2389
C	ASP2497-ILE2517
A	ILE2265-LEU2285
A	TYR2326-PHE2346
A	ILE2369-LEU2389
A	ASP2497-ILE2517
B	LEU2203-TYR2223
B	SER2225-THR2249
B	ILE2265-LEU2285

site_id	SWS_FT_FI3
Number of Residues	624
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	PRO2224-ASP2225
C	PRO2224-ASP2225
C	GLY2286-GLY2325
C	PHE2390-TYR2496
A	GLY2286-GLY2325
A	PHE2390-TYR2496
B	PRO2224-ASP2225
B	GLY2286-GLY2325
B	PHE2390-TYR2496
D	PRO2224-ASP2225
D	GLY2286-GLY2325
D	PHE2390-TYR2496

site_id	SWS_FT_FI4
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:6DQZ, ECO:0007744\|PDB:7T3P, ECO:0007744\|PDB:8TKF

Chain	Residue	Details
A	ARG266
B	LEU269
B	ARG510
B	TYR567
B	ARG568
B	LYS569
D	ARG266
D	THR268
D	LEU269
D	ARG510
D	TYR567
A	THR268
D	ARG568
D	LYS569
C	ARG266
C	THR268
C	LEU269
C	ARG510
C	TYR567
C	ARG568
C	LYS569
A	LEU269
A	ARG510
A	TYR567
A	ARG568
A	LYS569
B	ARG266
B	THR268

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:7T3P, ECO:0007744\|PDB:8TKF

Chain	Residue	Details
A	ARG270
B	ARG270
D	ARG270
C	ARG270

site_id	SWS_FT_FI6
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0000305\|PubMed:30013099, ECO:0007744\|PDB:6DQZ

Chain	Residue	Details
A	ARG503
B	ARG503
D	ARG503
C	ARG503

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:6DQN, ECO:0007744\|PDB:7T3P, ECO:0007744\|PDB:8TKF

Chain	Residue	Details
A	LYS507
B	LYS507
D	LYS507
C	LYS507

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0007744\|PDB:6DRA

Chain	Residue	Details
A	ARG743
B	ARG743
D	ARG743
C	ARG743

site_id	SWS_FT_FI9
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0007744\|PDB:6DR2, ECO:0007744\|PDB:6DRA

Chain	Residue	Details
A	GLU1122
B	GLU1122
D	GLU1122
C	GLU1122

site_id	SWS_FT_FI10
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:6DR2, ECO:0007744\|PDB:8TKG

Chain	Residue	Details
A	GLU1125
B	GLU1125
D	GLU1125
C	GLU1125

site_id	SWS_FT_FI11
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:6DRA, ECO:0007744\|PDB:7T3U, ECO:0007744\|PDB:8TL9

Chain	Residue	Details
A	GLU1882
C	GLU1882
C	GLU1946
C	THR2581
A	GLU1946
A	THR2581
B	GLU1882
B	GLU1946
B	THR2581
D	GLU1882
D	GLU1946
D	THR2581

site_id	SWS_FT_FI12
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:35301323, ECO:0007744\|PDB:7T3R

Chain	Residue	Details
A	ALA1996
A	GLU2149
B	ALA1996
B	GLU2149
D	ALA1996
D	GLU2149
C	ALA1996
C	GLU2149

site_id	SWS_FT_FI13
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:7T3R, ECO:0007744\|PDB:8TKG

Chain	Residue	Details
A	LYS2152
C	LYS2152
C	PHE2539
C	LYS2560
A	PHE2539
A	LYS2560
B	LYS2152
B	PHE2539
B	LYS2560
D	LYS2152
D	PHE2539
D	LYS2560

site_id	SWS_FT_FI14
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:30013099, ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:6DR0, ECO:0007744\|PDB:7T3P, ECO:0007744\|PDB:8TKD

Chain	Residue	Details
A	CYS2538
D	CYS2541
D	HIS2558
D	HIS2563
C	CYS2538
C	CYS2541
C	HIS2558
C	HIS2563
A	CYS2541
A	HIS2558
A	HIS2563
B	CYS2538
B	CYS2541
B	HIS2558
B	HIS2563
D	CYS2538

site_id	SWS_FT_FI15
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0000312\|PDB:8TKG, ECO:0007744\|PDB:7T3R

Chain	Residue	Details
A	ASN2564
B	ASN2564
D	ASN2564
C	ASN2564

site_id	SWS_FT_FI16
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:35301323, ECO:0000269\|PubMed:37898605, ECO:0007744\|PDB:7T3R, ECO:0007744\|PDB:8TKI

Chain	Residue	Details
A	MET2565
B	MET2565
D	MET2565
C	MET2565

site_id	SWS_FT_FI17
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER916
B	SER916
D	SER916
C	SER916

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER934
B	SER934
D	SER934
C	SER934

site_id	SWS_FT_FI19
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:19690332

Chain	Residue	Details
A	SER1813
B	SER1813
D	SER1813
C	SER1813

site_id	SWS_FT_FI20
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER1832
B	SER1832
D	SER1832
C	SER1832

site_id	SWS_FT_FI21
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER1834
A	SER2609
B	SER1834
B	SER2609
D	SER1834
D	SER2609
C	SER1834
C	SER2609

site_id	SWS_FT_FI22
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER2670
B	SER2670
D	SER2670
C	SER2670

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)