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6DQF

LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N68 i.e. 2-(1-(2-(piperidin-1-yl)ethyl)-1H-benzo[d]imidazol-2-yl)thieno[3,2-b]pyridine-7-carboxylic acid

Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue H61 A 601
ChainResidue
AARG73
ATRP503
ALEU536
AHIS571
AMN602
AHOH718
AHOH785
AHOH801
ATYR409
AASP412
ATRP470
ATYR472
APHE480
AHIS483
AASN493
ALYS501

site_idAC2
Number of Residues6
Detailsbinding site for residue MN A 602
ChainResidue
AHIS483
AGLU485
AHIS571
AH61601
AHOH718
AHOH785

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues50
DetailsZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:27427228
ChainResidueDetails
ATYR409
ASER491
AASN493
ALYS501

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454
ChainResidueDetails
AHIS483
AHIS571

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454
ChainResidueDetails
AGLU485

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER464

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALEU451

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PDB entries from 2024-07-24

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