6DQE
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N67 i.e. 2-(5-phenyl-4-(phenyl(2-(piperidin-1-yl)ethoxy)methyl)-1H-pyrazol-1-yl)isonicotinic acid
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue H6A A 601 |
| Chain | Residue |
| A | TYR409 |
| A | TRP503 |
| A | GLN535 |
| A | HIS571 |
| A | MN602 |
| A | DMS605 |
| A | HOH711 |
| A | HOH833 |
| A | HOH854 |
| A | ASP412 |
| A | TRP470 |
| A | TYR472 |
| A | PHE480 |
| A | HIS483 |
| A | ILE484 |
| A | GLU485 |
| A | LYS501 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | HIS483 |
| A | GLU485 |
| A | HIS571 |
| A | H6A601 |
| A | HOH833 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | MET380 |
| A | PRO381 |
| A | GLU485 |
| A | ASP486 |
| A | HIS487 |
| A | TRP488 |
| A | HOH701 |
| A | HOH719 |
| A | HOH764 |
| A | HOH771 |
| A | HOH790 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 604 |
| Chain | Residue |
| A | ASP531 |
| A | HIS534 |
| A | TYR570 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue DMS A 605 |
| Chain | Residue |
| A | TRP470 |
| A | TYR472 |
| A | GLU485 |
| A | ASN585 |
| A | H6A601 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 606 |
| Chain | Residue |
| A | MET384 |
| A | SER508 |
| A | HOH703 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Motif: {"description":"GSGFP motif","evidences":[{"source":"UniProtKB","id":"Q3UXZ9","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26645689","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214401","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27427228","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27499454","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
