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6DQA

Linked KDM5A JMJ Domain Bound to Inhibitor N70 i.e.[2-((3-aminophenyl)(2-(piperidin-1-yl)ethoxy)methyl)thieno[3,2-b]pyridine-7-carboxylic acid]

Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue H6V A 601
ChainResidue
AARG73
ATRP503
AHIS571
AMN602
AGOL604
AHOH754
AHOH772
ATYR409
AASP412
ATYR472
ASER479
APHE480
ACYS481
AHIS483
ALYS501

site_idAC2
Number of Residues6
Detailsbinding site for residue MN A 602
ChainResidue
AHIS483
AGLU485
AHIS571
AH6V601
AHOH729
AHOH772

site_idAC3
Number of Residues9
Detailsbinding site for residue GOL A 603
ChainResidue
ASER375
AASN379
AMET380
APRO381
AGLU485
AHIS487
ATRP488
AHOH703
AHOH787

site_idAC4
Number of Residues8
Detailsbinding site for residue GOL A 604
ChainResidue
ALYS45
AARG73
AGLN75
ACYS481
ALEU536
AH6V601
AHOH704
AHOH827

site_idAC5
Number of Residues2
Detailsbinding site for residue EDO A 605
ChainResidue
AMET540
AASN541

site_idAC6
Number of Residues5
Detailsbinding site for residue EDO A 606
ChainResidue
APHE354
AGLN356
ATYR490
APRO567
AHOH731

site_idAC7
Number of Residues3
Detailsbinding site for residue EDO A 607
ChainResidue
APRO15
AGLU388
AHOH759

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues50
DetailsZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:27427228
ChainResidueDetails
ATYR409
ASER491
AASN493
ALYS501

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454
ChainResidueDetails
AHIS483
AHIS571

site_idSWS_FT_FI4
Number of Residues1
DetailsBINDING: BINDING => ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454
ChainResidueDetails
AGLU485

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER464

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALEU451

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PDB entries from 2024-07-24

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