6DOX

Crystal Structure of Bacillus Halodurans Ribonuclease H1 in Complex with an RNA/DNA Hybrid: Reaction in 5 mM Mg2+ and 200 mM Rb+ for 360 s at 21 C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 201

Chain	Residue
A	ASP71
A	ASP192
A	HOH307
A	HOH315
A	HOH318
b	C5

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 202

Chain	Residue
B	U4
b	C5
A	ASP71
A	GLU109
A	ASP132

---

site_id	AC3
Number of Residues	10
Details	binding site for residue RB A 203

Chain	Residue
A	ASP192
A	GLY194
A	ARG195
A	LYS196
A	RB205
A	HOH307
A	HOH358
b	C5
b	G6
b	HOH203

---

site_id	AC4
Number of Residues	5
Details	binding site for residue RB A 204

Chain	Residue
A	LYS121
A	ASN124
A	HOH409
A	HOH412
A	HOH427

---

site_id	AC5
Number of Residues	7
Details	binding site for residue RB A 205

Chain	Residue
A	GLU188
A	ASP192
A	LYS196
A	RB203
A	HOH307
A	HOH358
b	C5

---

site_id	AC6
Number of Residues	2
Details	binding site for residue CL A 206

Chain	Residue
A	TYR83
A	GOL212

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL A 207

Chain	Residue
A	HOH354
A	HOH443

---

site_id	AC8
Number of Residues	3
Details	binding site for residue CL A 208

Chain	Residue
A	PRO177
A	HOH416
A	HOH450

---

site_id	AC9
Number of Residues	7
Details	binding site for residue GOL A 209

Chain	Residue
A	GLY76
A	ASN77
A	PRO78
A	HOH311
C	DG2
C	DA3
b	HOH205

---

site_id	AD1
Number of Residues	7
Details	binding site for residue GOL A 210

Chain	Residue
A	HIS115
A	TYR119
A	ARG123
A	GLU167
A	ASN170
A	GOL212
A	HOH304

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL A 211

Chain	Residue
A	GLU122
A	ARG123
A	LYS144
A	ARG151
A	ASP163
A	GLU166

---

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL A 212

Chain	Residue
A	HIS115
A	ARG118
A	ASN170
A	CL206
A	GOL210
A	HOH329
A	HOH422

---

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO A 213

Chain	Residue
A	TYR174
A	THR176
A	PRO177
A	ILE178
A	HOH355
A	HOH363

---

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO A 214

Chain	Residue
A	LYS143
A	THR173
A	TYR174

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 215

Chain	Residue
A	GLU66
A	SER125
A	LYS127
A	HOH339

---

site_id	AD7
Number of Residues	6
Details	binding site for residue GOL A 216

Chain	Residue
A	GLU98
A	PRO99
A	HIS172
A	HOH303
A	HOH353
A	HOH399

---

site_id	AD8
Number of Residues	6
Details	binding site for residue PEG A 217

Chain	Residue
A	PRO78
A	VAL150
A	ASN152
A	GLU154
A	HOH306
C	HOH201

---

site_id	AD9
Number of Residues	6
Details	binding site for residue EDO B 101

Chain	Residue
B	A1
C	DT6
C	RB101
C	EDO102
b	G6
b	HOH204

---

site_id	AE1
Number of Residues	4
Details	binding site for residue RB b 101

Chain	Residue
B	HOH206
b	C5
b	HOH201
B	U4

---

site_id	AE2
Number of Residues	5
Details	binding site for residue RB C 101

Chain	Residue
B	EDO101
C	DT4
C	DG5
C	EDO102
C	HOH211

---

site_id	AE3
Number of Residues	5
Details	binding site for residue EDO C 102

Chain	Residue
B	EDO101
C	DT4
C	DG5
C	RB101
C	EDO103

---

site_id	AE4
Number of Residues	5
Details	binding site for residue EDO C 103

Chain	Residue
A	THR148
C	DT4
C	DG5
C	EDO102
C	HOH204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:15989951

Chain	Residue	Details
A	ASP192
A	ASP71
A	GLU109
A	ASP132

---