6DMW

Calmodulin-bound full-length rbTRPV5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0005516	molecular_function	calmodulin binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0035809	biological_process	regulation of urine volume
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0055074	biological_process	calcium ion homeostasis
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0098655	biological_process	monoatomic cation transmembrane transport
A	0098703	biological_process	calcium ion import across plasma membrane
B	0005216	molecular_function	monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0005516	molecular_function	calmodulin binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0035809	biological_process	regulation of urine volume
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0055074	biological_process	calcium ion homeostasis
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0098655	biological_process	monoatomic cation transmembrane transport
B	0098703	biological_process	calcium ion import across plasma membrane
C	0005216	molecular_function	monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0005516	molecular_function	calmodulin binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0035809	biological_process	regulation of urine volume
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051289	biological_process	protein homotetramerization
C	0055074	biological_process	calcium ion homeostasis
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0098655	biological_process	monoatomic cation transmembrane transport
C	0098703	biological_process	calcium ion import across plasma membrane
D	0005216	molecular_function	monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0005516	molecular_function	calmodulin binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0016020	cellular_component	membrane
D	0016324	cellular_component	apical plasma membrane
D	0035809	biological_process	regulation of urine volume
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051289	biological_process	protein homotetramerization
D	0055074	biological_process	calcium ion homeostasis
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0098655	biological_process	monoatomic cation transmembrane transport
D	0098703	biological_process	calcium ion import across plasma membrane
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0001975	biological_process	response to amphetamine
E	0002027	biological_process	regulation of heart rate
E	0005246	molecular_function	calcium channel regulator activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0008179	molecular_function	adenylate cyclase binding
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0030017	cellular_component	sarcomere
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030426	cellular_component	growth cone
E	0030672	cellular_component	synaptic vesicle membrane
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
E	0031966	cellular_component	mitochondrial membrane
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035307	biological_process	positive regulation of protein dephosphorylation
E	0035458	biological_process	cellular response to interferon-beta
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0043548	molecular_function	phosphatidylinositol 3-kinase binding
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050998	molecular_function	nitric-oxide synthase binding
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0072542	molecular_function	protein phosphatase activator activity
E	0090150	biological_process	establishment of protein localization to membrane
E	0090151	biological_process	establishment of protein localization to mitochondrial membrane
E	0097225	cellular_component	sperm midpiece
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0099524	cellular_component	postsynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	1902494	cellular_component	catalytic complex
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
E	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA E 201

Chain	Residue
E	ASP21
E	ASP23
E	ASP25
E	THR27
E	GLU32

---

site_id	AC2
Number of Residues	5
Details	binding site for residue CA E 202

Chain	Residue
E	GLU105
E	ASP94
E	ASP96
E	ASN98
E	TYR100

---

site_id	AC3
Number of Residues	5
Details	binding site for residue CA E 203

Chain	Residue
E	ASP130
E	ASP132
E	ASP134
E	GLN136
E	GLU141

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
E	ASP21-LEU33
E	ASP57-PHE69
E	ASP94-LEU106
E	ASP130-PHE142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1G4Y, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3B32, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3IFK, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4G27, ECO:0007744|PDB:4G28, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4J9Y, ECO:0007744|PDB:4J9Z, ECO:0007744|PDB:4QNH

Chain	Residue	Details
B	ARG409-THR419
B	ARG470-ARG492
B	MET578-PHE730
C	MET1-PRO327
C	ARG409-THR419
C	ARG470-ARG492
C	MET578-PHE730
D	MET1-PRO327
D	ARG409-THR419
D	ARG470-ARG492
D	MET578-PHE730
E	ASP21
E	ASP23
E	ASP25
E	THR27
E	GLU32

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1G4Y, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3B32, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK4, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3IFK, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG6, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4G27, ECO:0007744|PDB:4G28, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4J9Y, ECO:0007744|PDB:4J9Z, ECO:0007744|PDB:4QNH

Chain	Residue	Details
A	ILE557-MET577
B	TYR328-ILE348
B	LEU386-PHE408
B	ILE420-MET442
B	GLY449-ALA469
B	PHE493-GLN513
B	ILE557-MET577
C	TYR328-ILE348
C	LEU386-PHE408
C	ILE420-MET442
C	GLY449-ALA469
C	PHE493-GLN513
C	ILE557-MET577
D	TYR328-ILE348
D	LEU386-PHE408
D	ILE420-MET442
D	GLY449-ALA469
D	PHE493-GLN513
D	ILE557-MET577
E	ASP57
E	ASP59
E	ASN61
E	THR63
E	GLU68

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK4, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG6, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD

Chain	Residue	Details
C	ARG443-ASN448
D	TYR349-ARG385
D	ARG443-ASN448
E	ASP94
E	ASP96
E	ASN98
E	TYR100
E	GLU105

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD

Chain	Residue	Details
E	GLU141
E	ASP130
E	ASP132
E	ASP134
E	GLN136

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:201628, ECO:0000269|Ref.8

Chain	Residue	Details
E	ALA2
B	ASP542
C	ASP542
D	ASP542

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
E	LYS22
B	THR685
C	THR685
D	THR685

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000269|PubMed:12392717

Chain	Residue	Details
E	THR45
B	SER689
C	SER689
D	SER689

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
E	SER82
B	ASN358
C	ASN358
D	ASN358

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
E	LYS95

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
E	TYR100

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
E	SER102

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
E	THR111

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
E	LYS116

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
E	TYR139

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
E	LYS22

---