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6DMB

Cryo-EM structure of human Ptch1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0001841biological_processneural tube formation
A0005113molecular_functionpatched binding
A0005119molecular_functionsmoothened binding
A0005515molecular_functionprotein binding
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0005901cellular_componentcaveola
A0005929cellular_componentcilium
A0007165biological_processsignal transduction
A0007286biological_processspermatid development
A0007420biological_processbrain development
A0008158molecular_functionhedgehog receptor activity
A0008201molecular_functionheparin binding
A0008589biological_processregulation of smoothened signaling pathway
A0009410biological_processresponse to xenobiotic stimulus
A0009612biological_processresponse to mechanical stimulus
A0009887biological_processanimal organ morphogenesis
A0009953biological_processdorsal/ventral pattern formation
A0010875biological_processpositive regulation of cholesterol efflux
A0015485molecular_functioncholesterol binding
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0021532biological_processneural tube patterning
A0021997biological_processneural plate axis specification
A0030326biological_processembryonic limb morphogenesis
A0030332molecular_functioncyclin binding
A0030496cellular_componentmidbody
A0030666cellular_componentendocytic vesicle membrane
A0030850biological_processprostate gland development
A0032355biological_processresponse to estradiol
A0032526biological_processresponse to retinoic acid
A0032880biological_processregulation of protein localization
A0035108biological_processlimb morphogenesis
A0040015biological_processnegative regulation of multicellular organism growth
A0043279biological_processresponse to alkaloid
A0044294cellular_componentdendritic growth cone
A0044295cellular_componentaxonal growth cone
A0044877molecular_functionprotein-containing complex binding
A0045177cellular_componentapical part of cell
A0045211cellular_componentpostsynaptic membrane
A0045668biological_processnegative regulation of osteoblast differentiation
A0045879biological_processnegative regulation of smoothened signaling pathway
A0045892biological_processnegative regulation of DNA-templated transcription
A0045893biological_processpositive regulation of DNA-templated transcription
A0048471cellular_componentperinuclear region of cytoplasm
A0048745biological_processsmooth muscle tissue development
A0051782biological_processnegative regulation of cell division
A0060037biological_processpharyngeal system development
A0060170cellular_componentciliary membrane
A0061053biological_processsomite development
A0071397biological_processcellular response to cholesterol
A0071679biological_processcommissural neuron axon guidance
A0072205biological_processmetanephric collecting duct development
A0072659biological_processprotein localization to plasma membrane
A0097108molecular_functionhedgehog family protein binding
A0097421biological_processliver regeneration
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues239
DetailsTransmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues604
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues60
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues160
DetailsDomain: {"description":"SSD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00199","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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