6DJZ
Human sigma-1 receptor bound to haloperidol
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005634 | cellular_component | nucleus |
A | 0005635 | cellular_component | nuclear envelope |
A | 0005637 | cellular_component | nuclear inner membrane |
A | 0005640 | cellular_component | nuclear outer membrane |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005811 | cellular_component | lipid droplet |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006869 | biological_process | lipid transport |
A | 0007399 | biological_process | nervous system development |
A | 0014069 | cellular_component | postsynaptic density |
A | 0016020 | cellular_component | membrane |
A | 0030426 | cellular_component | growth cone |
A | 0031410 | cellular_component | cytoplasmic vesicle |
A | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
A | 0038023 | molecular_function | signaling receptor activity |
A | 0042995 | cellular_component | cell projection |
A | 0043523 | biological_process | regulation of neuron apoptotic process |
A | 0045202 | cellular_component | synapse |
A | 0045211 | cellular_component | postsynaptic membrane |
A | 0070161 | cellular_component | anchoring junction |
A | 0070207 | biological_process | protein homotrimerization |
A | 0098839 | cellular_component | postsynaptic density membrane |
B | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005635 | cellular_component | nuclear envelope |
B | 0005637 | cellular_component | nuclear inner membrane |
B | 0005640 | cellular_component | nuclear outer membrane |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0005811 | cellular_component | lipid droplet |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006869 | biological_process | lipid transport |
B | 0007399 | biological_process | nervous system development |
B | 0014069 | cellular_component | postsynaptic density |
B | 0016020 | cellular_component | membrane |
B | 0030426 | cellular_component | growth cone |
B | 0031410 | cellular_component | cytoplasmic vesicle |
B | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
B | 0038023 | molecular_function | signaling receptor activity |
B | 0042995 | cellular_component | cell projection |
B | 0043523 | biological_process | regulation of neuron apoptotic process |
B | 0045202 | cellular_component | synapse |
B | 0045211 | cellular_component | postsynaptic membrane |
B | 0070161 | cellular_component | anchoring junction |
B | 0070207 | biological_process | protein homotrimerization |
B | 0098839 | cellular_component | postsynaptic density membrane |
C | 0004985 | molecular_function | G protein-coupled opioid receptor activity |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005635 | cellular_component | nuclear envelope |
C | 0005637 | cellular_component | nuclear inner membrane |
C | 0005640 | cellular_component | nuclear outer membrane |
C | 0005783 | cellular_component | endoplasmic reticulum |
C | 0005789 | cellular_component | endoplasmic reticulum membrane |
C | 0005811 | cellular_component | lipid droplet |
C | 0005829 | cellular_component | cytosol |
C | 0005886 | cellular_component | plasma membrane |
C | 0006869 | biological_process | lipid transport |
C | 0007399 | biological_process | nervous system development |
C | 0014069 | cellular_component | postsynaptic density |
C | 0016020 | cellular_component | membrane |
C | 0030426 | cellular_component | growth cone |
C | 0031410 | cellular_component | cytoplasmic vesicle |
C | 0038003 | biological_process | G protein-coupled opioid receptor signaling pathway |
C | 0038023 | molecular_function | signaling receptor activity |
C | 0042995 | cellular_component | cell projection |
C | 0043523 | biological_process | regulation of neuron apoptotic process |
C | 0045202 | cellular_component | synapse |
C | 0045211 | cellular_component | postsynaptic membrane |
C | 0070161 | cellular_component | anchoring junction |
C | 0070207 | biological_process | protein homotrimerization |
C | 0098839 | cellular_component | postsynaptic density membrane |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | binding site for residue GMJ A 301 |
Chain | Residue |
A | MET93 |
A | THR160 |
A | VAL162 |
A | GLU172 |
A | THR181 |
A | LEU182 |
A | TYR206 |
A | HOH402 |
A | TYR103 |
A | SER117 |
A | TYR120 |
A | ASP126 |
A | GLN135 |
A | VAL152 |
A | VAL153 |
A | HIS154 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 302 |
Chain | Residue |
A | GLU78 |
A | ARG208 |
A | ARG211 |
A | OLC313 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 303 |
Chain | Residue |
A | GLN38 |
A | ARG39 |
A | ARG175 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 304 |
Chain | Residue |
A | ASP53 |
A | HIS54 |
A | ASN167 |
site_id | AC5 |
Number of Residues | 1 |
Details | binding site for residue SO4 A 305 |
Chain | Residue |
A | ARG204 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 306 |
Chain | Residue |
A | ARG114 |
B | ARG114 |
C | ARG114 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 307 |
Chain | Residue |
A | ARG60 |
C | SER130 |
C | GLY131 |
C | PRO148 |
C | SO4305 |
site_id | AC8 |
Number of Residues | 2 |
Details | binding site for residue SO4 A 308 |
Chain | Residue |
A | ARG137 |
A | THR140 |
site_id | AC9 |
Number of Residues | 3 |
Details | binding site for residue GOL A 309 |
Chain | Residue |
A | LEU79 |
A | TRP81 |
A | CYS94 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue GOL A 310 |
Chain | Residue |
A | SER59 |
A | ILE62 |
A | ASP76 |
A | LEU79 |
site_id | AD2 |
Number of Residues | 1 |
Details | binding site for residue OLC A 311 |
Chain | Residue |
A | TRP29 |
site_id | AD3 |
Number of Residues | 1 |
Details | binding site for residue OLC A 312 |
Chain | Residue |
C | GLN221 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue OLC A 313 |
Chain | Residue |
A | LEU203 |
A | ARG204 |
A | ALA207 |
A | ARG211 |
A | SO4302 |
site_id | AD5 |
Number of Residues | 15 |
Details | binding site for residue GMJ B 301 |
Chain | Residue |
B | TRP89 |
B | TYR103 |
B | LEU105 |
B | SER117 |
B | TYR120 |
B | ASP126 |
B | PHE133 |
B | GLN135 |
B | VAL152 |
B | HIS154 |
B | VAL162 |
B | GLU172 |
B | LEU182 |
B | ALA185 |
B | HOH402 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue SO4 B 302 |
Chain | Residue |
B | ARG208 |
B | ARG211 |
site_id | AD7 |
Number of Residues | 1 |
Details | binding site for residue SO4 B 303 |
Chain | Residue |
B | ARG204 |
site_id | AD8 |
Number of Residues | 3 |
Details | binding site for residue SO4 B 304 |
Chain | Residue |
B | ARG39 |
B | ARG175 |
B | HOH401 |
site_id | AD9 |
Number of Residues | 4 |
Details | binding site for residue SO4 B 305 |
Chain | Residue |
B | ASP53 |
B | HIS54 |
B | SER130 |
B | HOH403 |
site_id | AE1 |
Number of Residues | 2 |
Details | binding site for residue GOL B 306 |
Chain | Residue |
B | LEU79 |
B | TRP81 |
site_id | AE2 |
Number of Residues | 14 |
Details | binding site for residue GMJ C 301 |
Chain | Residue |
C | TRP89 |
C | MET93 |
C | LEU95 |
C | LEU105 |
C | SER117 |
C | TYR120 |
C | ASP126 |
C | GLN135 |
C | VAL162 |
C | GLU172 |
C | THR181 |
C | LEU182 |
C | ALA185 |
C | TYR206 |
site_id | AE3 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 302 |
Chain | Residue |
C | ARG208 |
C | ARG211 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 303 |
Chain | Residue |
C | ARG39 |
C | ARG175 |
site_id | AE5 |
Number of Residues | 2 |
Details | binding site for residue SO4 C 304 |
Chain | Residue |
C | ARG204 |
C | ARG204 |
site_id | AE6 |
Number of Residues | 4 |
Details | binding site for residue SO4 C 305 |
Chain | Residue |
C | ASP53 |
C | HIS54 |
C | SER130 |
A | SO4307 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue GOL C 306 |
Chain | Residue |
C | TRP81 |
C | CYS94 |
C | GOL307 |
site_id | AE8 |
Number of Residues | 2 |
Details | binding site for residue GOL C 307 |
Chain | Residue |
C | ASP76 |
C | GOL306 |
site_id | AE9 |
Number of Residues | 2 |
Details | binding site for residue OLC C 308 |
Chain | Residue |
C | TRP121 |
C | GLU123 |
site_id | AF1 |
Number of Residues | 4 |
Details | binding site for residue OLC C 309 |
Chain | Residue |
C | TRP29 |
C | LEU100 |
C | SER101 |
C | GLY176 |
site_id | AF2 |
Number of Residues | 5 |
Details | binding site for residue OLC C 310 |
Chain | Residue |
A | TRP27 |
C | TRP29 |
C | GLN33 |
C | SER101 |
C | OLC311 |
site_id | AF3 |
Number of Residues | 4 |
Details | binding site for residue OLC C 311 |
Chain | Residue |
C | SER99 |
C | GLU213 |
C | LEU214 |
C | OLC310 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | TOPO_DOM: Lumenal => ECO:0000305|PubMed:27042935 |
Chain | Residue | Details |
A | MET1-TRP9 | |
B | MET1-TRP9 | |
C | MET1-TRP9 |
site_id | SWS_FT_FI2 |
Number of Residues | 60 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:27042935 |
Chain | Residue | Details |
A | ALA10-LEU30 | |
B | ALA10-LEU30 | |
C | ALA10-LEU30 |
site_id | SWS_FT_FI3 |
Number of Residues | 576 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:27042935 |
Chain | Residue | Details |
A | GLY31-PRO223 | |
B | GLY31-PRO223 | |
C | GLY31-PRO223 |
site_id | SWS_FT_FI4 |
Number of Residues | 6 |
Details | SITE: Important for ligand binding => ECO:0000269|PubMed:11476895 |
Chain | Residue | Details |
A | ASP126 | |
A | GLU172 | |
B | ASP126 | |
B | GLU172 | |
C | ASP126 | |
C | GLU172 |