Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DJZ

Human sigma-1 receptor bound to haloperidol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001516	biological_process	prostaglandin biosynthetic process
A	0004985	molecular_function	G protein-coupled opioid receptor activity
A	0005515	molecular_function	protein binding
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005640	cellular_component	nuclear outer membrane
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0007399	biological_process	nervous system development
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0019371	biological_process	cyclooxygenase pathway
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0030426	cellular_component	growth cone
A	0031410	cellular_component	cytoplasmic vesicle
A	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
A	0038023	molecular_function	signaling receptor activity
A	0043025	cellular_component	neuronal cell body
A	0043523	biological_process	regulation of neuron apoptotic process
A	0043524	biological_process	negative regulation of neuron apoptotic process
A	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
A	0070161	cellular_component	anchoring junction
A	0070207	biological_process	protein homotrimerization
A	0097305	biological_process	response to alcohol
A	0098794	cellular_component	postsynapse
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	0150052	biological_process	regulation of postsynapse assembly
A	1903573	biological_process	negative regulation of response to endoplasmic reticulum stress
A	1904313	biological_process	response to methamphetamine hydrochloride
A	1904751	biological_process	positive regulation of protein localization to nucleolus
A	1990708	biological_process	conditioned place preference
B	0001516	biological_process	prostaglandin biosynthetic process
B	0004985	molecular_function	G protein-coupled opioid receptor activity
B	0005515	molecular_function	protein binding
B	0005635	cellular_component	nuclear envelope
B	0005637	cellular_component	nuclear inner membrane
B	0005640	cellular_component	nuclear outer membrane
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0007399	biological_process	nervous system development
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0019371	biological_process	cyclooxygenase pathway
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0030426	cellular_component	growth cone
B	0031410	cellular_component	cytoplasmic vesicle
B	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
B	0038023	molecular_function	signaling receptor activity
B	0043025	cellular_component	neuronal cell body
B	0043523	biological_process	regulation of neuron apoptotic process
B	0043524	biological_process	negative regulation of neuron apoptotic process
B	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
B	0070161	cellular_component	anchoring junction
B	0070207	biological_process	protein homotrimerization
B	0097305	biological_process	response to alcohol
B	0098794	cellular_component	postsynapse
B	0098839	cellular_component	postsynaptic density membrane
B	0098978	cellular_component	glutamatergic synapse
B	0150052	biological_process	regulation of postsynapse assembly
B	1903573	biological_process	negative regulation of response to endoplasmic reticulum stress
B	1904313	biological_process	response to methamphetamine hydrochloride
B	1904751	biological_process	positive regulation of protein localization to nucleolus
B	1990708	biological_process	conditioned place preference
C	0001516	biological_process	prostaglandin biosynthetic process
C	0004985	molecular_function	G protein-coupled opioid receptor activity
C	0005515	molecular_function	protein binding
C	0005635	cellular_component	nuclear envelope
C	0005637	cellular_component	nuclear inner membrane
C	0005640	cellular_component	nuclear outer membrane
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0007399	biological_process	nervous system development
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0019371	biological_process	cyclooxygenase pathway
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0030426	cellular_component	growth cone
C	0031410	cellular_component	cytoplasmic vesicle
C	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
C	0038023	molecular_function	signaling receptor activity
C	0043025	cellular_component	neuronal cell body
C	0043523	biological_process	regulation of neuron apoptotic process
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
C	0070161	cellular_component	anchoring junction
C	0070207	biological_process	protein homotrimerization
C	0097305	biological_process	response to alcohol
C	0098794	cellular_component	postsynapse
C	0098839	cellular_component	postsynaptic density membrane
C	0098978	cellular_component	glutamatergic synapse
C	0150052	biological_process	regulation of postsynapse assembly
C	1903573	biological_process	negative regulation of response to endoplasmic reticulum stress
C	1904313	biological_process	response to methamphetamine hydrochloride
C	1904751	biological_process	positive regulation of protein localization to nucleolus
C	1990708	biological_process	conditioned place preference

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue GMJ A 301

Chain	Residue
A	MET93
A	THR160
A	VAL162
A	GLU172
A	THR181
A	LEU182
A	TYR206
A	HOH402
A	TYR103
A	SER117
A	TYR120
A	ASP126
A	GLN135
A	VAL152
A	VAL153
A	HIS154

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	GLU78
A	ARG208
A	ARG211
A	OLC313

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 303

Chain	Residue
A	GLN38
A	ARG39
A	ARG175

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 304

Chain	Residue
A	ASP53
A	HIS54
A	ASN167

site_id	AC5
Number of Residues	1
Details	binding site for residue SO4 A 305

Chain	Residue
A	ARG204

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 306

Chain	Residue
A	ARG114
B	ARG114
C	ARG114

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 A 307

Chain	Residue
A	ARG60
C	SER130
C	GLY131
C	PRO148
C	SO4305

site_id	AC8
Number of Residues	2
Details	binding site for residue SO4 A 308

Chain	Residue
A	ARG137
A	THR140

site_id	AC9
Number of Residues	3
Details	binding site for residue GOL A 309

Chain	Residue
A	LEU79
A	TRP81
A	CYS94

site_id	AD1
Number of Residues	4
Details	binding site for residue GOL A 310

Chain	Residue
A	SER59
A	ILE62
A	ASP76
A	LEU79

site_id	AD2
Number of Residues	1
Details	binding site for residue OLC A 311

Chain	Residue
A	TRP29

site_id	AD3
Number of Residues	1
Details	binding site for residue OLC A 312

Chain	Residue
C	GLN221

site_id	AD4
Number of Residues	5
Details	binding site for residue OLC A 313

Chain	Residue
A	LEU203
A	ARG204
A	ALA207
A	ARG211
A	SO4302

site_id	AD5
Number of Residues	15
Details	binding site for residue GMJ B 301

Chain	Residue
B	TRP89
B	TYR103
B	LEU105
B	SER117
B	TYR120
B	ASP126
B	PHE133
B	GLN135
B	VAL152
B	HIS154
B	VAL162
B	GLU172
B	LEU182
B	ALA185
B	HOH402

site_id	AD6
Number of Residues	2
Details	binding site for residue SO4 B 302

Chain	Residue
B	ARG208
B	ARG211

site_id	AD7
Number of Residues	1
Details	binding site for residue SO4 B 303

Chain	Residue
B	ARG204

site_id	AD8
Number of Residues	3
Details	binding site for residue SO4 B 304

Chain	Residue
B	ARG39
B	ARG175
B	HOH401

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 B 305

Chain	Residue
B	ASP53
B	HIS54
B	SER130
B	HOH403

site_id	AE1
Number of Residues	2
Details	binding site for residue GOL B 306

Chain	Residue
B	LEU79
B	TRP81

site_id	AE2
Number of Residues	14
Details	binding site for residue GMJ C 301

Chain	Residue
C	TRP89
C	MET93
C	LEU95
C	LEU105
C	SER117
C	TYR120
C	ASP126
C	GLN135
C	VAL162
C	GLU172
C	THR181
C	LEU182
C	ALA185
C	TYR206

site_id	AE3
Number of Residues	2
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG208
C	ARG211

site_id	AE4
Number of Residues	2
Details	binding site for residue SO4 C 303

Chain	Residue
C	ARG39
C	ARG175

site_id	AE5
Number of Residues	2
Details	binding site for residue SO4 C 304

Chain	Residue
C	ARG204
C	ARG204

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 C 305

Chain	Residue
C	ASP53
C	HIS54
C	SER130
A	SO4307

site_id	AE7
Number of Residues	3
Details	binding site for residue GOL C 306

Chain	Residue
C	TRP81
C	CYS94
C	GOL307

site_id	AE8
Number of Residues	2
Details	binding site for residue GOL C 307

Chain	Residue
C	ASP76
C	GOL306

site_id	AE9
Number of Residues	2
Details	binding site for residue OLC C 308

Chain	Residue
C	TRP121
C	GLU123

site_id	AF1
Number of Residues	4
Details	binding site for residue OLC C 309

Chain	Residue
C	TRP29
C	LEU100
C	SER101
C	GLY176

site_id	AF2
Number of Residues	5
Details	binding site for residue OLC C 310

Chain	Residue
A	TRP27
C	TRP29
C	GLN33
C	SER101
C	OLC311

site_id	AF3
Number of Residues	4
Details	binding site for residue OLC C 311

Chain	Residue
C	SER99
C	GLU213
C	LEU214
C	OLC310

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27042935","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	21
Details	Region: {"description":"Important for ligand-binding","evidences":[{"source":"UniProtKB","id":"Q60492","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Site: {"description":"Important for ligand binding","evidences":[{"source":"PubMed","id":"11476895","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"27042935","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Region: {"description":"Targeting to endoplasmic reticulum-associated lipid droplets","evidences":[{"source":"UniProtKB","id":"O55242","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)