6DJG
Crystal structure of Tdp1 catalytic domain in complex with compound XZ503
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 701 |
| Chain | Residue |
| A | ASP322 |
| A | ASN369 |
| A | HOH810 |
| A | HOH918 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue GNJ A 702 |
| Chain | Residue |
| A | PRO461 |
| A | HIS493 |
| A | TRP590 |
| A | HOH941 |
| A | HOH1055 |
| A | TYR204 |
| A | HIS263 |
| A | LYS265 |
| A | ASN283 |
| A | GLY458 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 701 |
| Chain | Residue |
| B | ILE355 |
| B | GLY356 |
| B | SER357 |
| B | THR513 |
| B | ALA515 |
| B | TRP522 |
| B | GLY540 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GNJ B 702 |
| Chain | Residue |
| B | TYR204 |
| B | HIS263 |
| B | LYS265 |
| B | ASN283 |
| B | GLY458 |
| B | PRO461 |
| B | HIS493 |
| B | TRP590 |
| B | HOH918 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15111055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15111055","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"12470949","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
