6DIW

Crystal structure of HCV NS3/4A D168A protease in complex with P4-1 (AJ-71)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	26
Details	binding site for residue GKG A 1201

Chain	Residue
A	HIS982
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	VAL1158
A	GLN1041
A	SO41202
A	HOH1320
A	HOH1352
A	HOH1372
A	HOH1422
A	HOH1433
A	HOH1474
A	PHE1043
A	TYR1056
A	HIS1057
A	GLY1058
A	VAL1078
A	ASP1081
A	ARG1123

---

site_id	AC2
Number of Residues	10
Details	binding site for residue SO4 A 1202

Chain	Residue
A	TYR1006
A	GLN1008
A	TYR1056
A	GKG1201
A	HOH1347
A	HOH1348
A	HOH1374
A	HOH1380
A	HOH1388
A	HOH1404

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 A 1203

Chain	Residue
A	THR1040
A	GLN1041
A	ARG1062
A	HOH1303
A	HOH1304
A	HOH1355
A	HOH1389
A	HOH1458

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 1204

Chain	Residue
A	ARG1109
A	HIS1110
A	GOL1207
A	HOH1337
A	HOH1346
A	HOH1438

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 1205

Chain	Residue
A	SER1122
A	ARG1123
A	ARG1155
A	GOL1208
A	HOH1319

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 1206

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---

site_id	AC7
Number of Residues	7
Details	binding site for residue GOL A 1207

Chain	Residue
A	GLN1009
A	THR1061
A	SO41204
A	HOH1318
A	HOH1346
A	HOH1415
A	HOH1484

---

site_id	AC8
Number of Residues	10
Details	binding site for residue GOL A 1208

Chain	Residue
A	ASN1049
A	GLY1050
A	ASP1121
A	SER1122
A	SO41205
A	HOH1315
A	HOH1329
A	HOH1330
A	HOH1339
A	HOH1429

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL A 1209

Chain	Residue
A	GLY990
A	SER1020
A	ALA1039
A	ARG1062
A	HOH1313

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL A 1210

Chain	Residue
A	ARG1011
A	ARG1024
A	ASP1025
A	LYS1026
A	HOH1391
A	HOH1468

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL A 1211

Chain	Residue
A	HIS982
A	SER1159
A	THR1160
A	ARG1161
A	GLY1162
A	HOH1501

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