6DIW
Crystal structure of HCV NS3/4A D168A protease in complex with P4-1 (AJ-71)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003724 | molecular_function | RNA helicase activity |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0019087 | biological_process | symbiont-mediated transformation of host cell |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| A | 0039545 | biological_process | symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity |
| A | 0043657 | cellular_component | host cell |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0055036 | cellular_component | virion membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue GKG A 1201 |
| Chain | Residue |
| A | HIS982 |
| A | LEU1135 |
| A | LYS1136 |
| A | GLY1137 |
| A | SER1138 |
| A | SER1139 |
| A | PHE1154 |
| A | ARG1155 |
| A | ALA1156 |
| A | ALA1157 |
| A | VAL1158 |
| A | GLN1041 |
| A | SO41202 |
| A | HOH1320 |
| A | HOH1352 |
| A | HOH1372 |
| A | HOH1422 |
| A | HOH1433 |
| A | HOH1474 |
| A | PHE1043 |
| A | TYR1056 |
| A | HIS1057 |
| A | GLY1058 |
| A | VAL1078 |
| A | ASP1081 |
| A | ARG1123 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 1202 |
| Chain | Residue |
| A | TYR1006 |
| A | GLN1008 |
| A | TYR1056 |
| A | GKG1201 |
| A | HOH1347 |
| A | HOH1348 |
| A | HOH1374 |
| A | HOH1380 |
| A | HOH1388 |
| A | HOH1404 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1203 |
| Chain | Residue |
| A | THR1040 |
| A | GLN1041 |
| A | ARG1062 |
| A | HOH1303 |
| A | HOH1304 |
| A | HOH1355 |
| A | HOH1389 |
| A | HOH1458 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1204 |
| Chain | Residue |
| A | ARG1109 |
| A | HIS1110 |
| A | GOL1207 |
| A | HOH1337 |
| A | HOH1346 |
| A | HOH1438 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1205 |
| Chain | Residue |
| A | SER1122 |
| A | ARG1123 |
| A | ARG1155 |
| A | GOL1208 |
| A | HOH1319 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1206 |
| Chain | Residue |
| A | CYS1097 |
| A | CYS1099 |
| A | CYS1145 |
| A | HIS1149 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 1207 |
| Chain | Residue |
| A | GLN1009 |
| A | THR1061 |
| A | SO41204 |
| A | HOH1318 |
| A | HOH1346 |
| A | HOH1415 |
| A | HOH1484 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 1208 |
| Chain | Residue |
| A | ASN1049 |
| A | GLY1050 |
| A | ASP1121 |
| A | SER1122 |
| A | SO41205 |
| A | HOH1315 |
| A | HOH1329 |
| A | HOH1330 |
| A | HOH1339 |
| A | HOH1429 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 1209 |
| Chain | Residue |
| A | GLY990 |
| A | SER1020 |
| A | ALA1039 |
| A | ARG1062 |
| A | HOH1313 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1210 |
| Chain | Residue |
| A | ARG1011 |
| A | ARG1024 |
| A | ASP1025 |
| A | LYS1026 |
| A | HOH1391 |
| A | HOH1468 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 1211 |
| Chain | Residue |
| A | HIS982 |
| A | SER1159 |
| A | THR1160 |
| A | ARG1161 |
| A | GLY1162 |
| A | HOH1501 |
