6DIU

Crystal structure of HCV NS3/4A protease in complex with P4-3(AJ-74)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0019062	biological_process	virion attachment to host cell
A	0019087	biological_process	transformation of host cell by virus
A	0033644	cellular_component	host cell membrane
A	0044423	cellular_component	virion component
A	0046718	biological_process	symbiont entry into host cell
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 1201

Chain	Residue
A	CYS1097
A	CYS1099
A	CYS1145
A	HIS1149

---

site_id	AC2
Number of Residues	9
Details	binding site for residue SO4 A 1202

Chain	Residue
A	HOH1353
A	HOH1386
A	HOH1403
A	HOH1406
A	TYR1006
A	GLN1008
A	TYR1056
A	GKM1206
A	HOH1348

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 A 1203

Chain	Residue
A	ARG1109
A	HIS1110
A	GOL1210
A	HOH1333
A	HOH1374
A	HOH1395
A	HOH1412

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 1204

Chain	Residue
A	LYS1080
A	ARG1155
A	PRO1171
A	SER1174
A	HOH1334

---

site_id	AC5
Number of Residues	8
Details	binding site for residue SO4 A 1205

Chain	Residue
A	LYS989
A	GLY990
A	ALA1039
A	ARG1062
A	HOH1303
A	HOH1313
A	HOH1324
A	HOH1327

---

site_id	AC6
Number of Residues	24
Details	binding site for residue GKM A 1206

Chain	Residue
A	HIS982
A	GLN1041
A	PHE1043
A	TYR1056
A	HIS1057
A	GLY1058
A	VAL1078
A	ASP1081
A	ARG1123
A	LEU1135
A	LYS1136
A	GLY1137
A	SER1138
A	SER1139
A	PHE1154
A	ARG1155
A	ALA1156
A	ALA1157
A	SO41202
A	HOH1344
A	HOH1367
A	HOH1405
A	HOH1431
A	HOH1437

---

site_id	AC7
Number of Residues	6
Details	binding site for residue GOL A 1207

Chain	Residue
A	LYS989
A	THR1040
A	GLN1041
A	ARG1062
A	HOH1350
A	HOH1393

---

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL A 1208

Chain	Residue
A	ASN1049
A	GLY1050
A	ASP1121
A	SER1122
A	ARG1123
A	HOH1392
A	HOH1453

---

site_id	AC9
Number of Residues	11
Details	binding site for residue GOL A 1209

Chain	Residue
A	GLN1086
A	CYS1097
A	THR1098
A	CYS1099
A	GLY1100
A	ARG1118
A	GLU1173
A	HOH1306
A	HOH1316
A	HOH1361
A	HOH1375

---

site_id	AD1
Number of Residues	9
Details	binding site for residue GOL A 1210

Chain	Residue
A	VAL995
A	GLN1009
A	THR1042
A	ARG1109
A	SO41203
A	HOH1304
A	HOH1310
A	HOH1318
A	HOH1416

---

site_id	AD2
Number of Residues	7
Details	binding site for residue GOL A 1211

Chain	Residue
A	GLN1017
A	SER1037
A	THR1038
A	ALA1039
A	GLN1041
A	THR1042
A	HOH1438

---