6DIR
Crystal structure of HCV NS3/4A protease in complex with P4-P5-2 (AJ-67)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006508 | biological_process | proteolysis |
A | 0008233 | molecular_function | peptidase activity |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0016020 | cellular_component | membrane |
A | 0019062 | biological_process | virion attachment to host cell |
A | 0019087 | biological_process | transformation of host cell by virus |
A | 0033644 | cellular_component | host cell membrane |
A | 0044423 | cellular_component | virion component |
A | 0046718 | biological_process | symbiont entry into host cell |
A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | binding site for residue GKA A 1201 |
Chain | Residue |
A | HIS982 |
A | LYS1136 |
A | GLY1137 |
A | SER1138 |
A | SER1139 |
A | PHE1154 |
A | ARG1155 |
A | ALA1156 |
A | ALA1157 |
A | VAL1158 |
A | SER1159 |
A | GLN1041 |
A | SO41202 |
A | HOH1366 |
A | HOH1391 |
A | HOH1412 |
A | HOH1423 |
A | PHE1043 |
A | TYR1056 |
A | HIS1057 |
A | GLY1058 |
A | VAL1078 |
A | ASP1081 |
A | LEU1135 |
site_id | AC2 |
Number of Residues | 10 |
Details | binding site for residue SO4 A 1202 |
Chain | Residue |
A | TYR1006 |
A | GLN1008 |
A | TYR1056 |
A | GKA1201 |
A | HOH1321 |
A | HOH1354 |
A | HOH1362 |
A | HOH1376 |
A | HOH1386 |
A | HOH1392 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue SO4 A 1203 |
Chain | Residue |
A | ARG1109 |
A | HIS1110 |
A | HOH1340 |
A | HOH1379 |
A | HOH1385 |
A | HOH1399 |
A | HOH1405 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1204 |
Chain | Residue |
A | CYS1097 |
A | CYS1099 |
A | CYS1145 |
A | HIS1149 |