Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DII

Structure of Arabidopsis Fatty Acid Amide Hydrolase in Complex with methyl linolenyl fluorophosphonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000325	cellular_component	plant-type vacuole
A	0003824	molecular_function	catalytic activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005794	cellular_component	Golgi apparatus
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0009536	cellular_component	plastid
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
A	0017064	molecular_function	fatty acid amide hydrolase activity
A	0042742	biological_process	defense response to bacterium
A	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
A	0070291	biological_process	N-acylethanolamine metabolic process
B	0000325	cellular_component	plant-type vacuole
B	0003824	molecular_function	catalytic activity
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005794	cellular_component	Golgi apparatus
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0009536	cellular_component	plastid
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
B	0017064	molecular_function	fatty acid amide hydrolase activity
B	0042742	biological_process	defense response to bacterium
B	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
B	0070291	biological_process	N-acylethanolamine metabolic process
C	0000325	cellular_component	plant-type vacuole
C	0003824	molecular_function	catalytic activity
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005794	cellular_component	Golgi apparatus
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0009536	cellular_component	plastid
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
C	0017064	molecular_function	fatty acid amide hydrolase activity
C	0042742	biological_process	defense response to bacterium
C	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
C	0070291	biological_process	N-acylethanolamine metabolic process
D	0000325	cellular_component	plant-type vacuole
D	0003824	molecular_function	catalytic activity
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005794	cellular_component	Golgi apparatus
D	0005886	cellular_component	plasma membrane
D	0006629	biological_process	lipid metabolic process
D	0009536	cellular_component	plastid
D	0016020	cellular_component	membrane
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
D	0017064	molecular_function	fatty acid amide hydrolase activity
D	0042742	biological_process	defense response to bacterium
D	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
D	0070291	biological_process	N-acylethanolamine metabolic process
E	0000325	cellular_component	plant-type vacuole
E	0003824	molecular_function	catalytic activity
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005794	cellular_component	Golgi apparatus
E	0005886	cellular_component	plasma membrane
E	0006629	biological_process	lipid metabolic process
E	0009536	cellular_component	plastid
E	0016020	cellular_component	membrane
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
E	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
E	0017064	molecular_function	fatty acid amide hydrolase activity
E	0042742	biological_process	defense response to bacterium
E	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
E	0070291	biological_process	N-acylethanolamine metabolic process
F	0000325	cellular_component	plant-type vacuole
F	0003824	molecular_function	catalytic activity
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005794	cellular_component	Golgi apparatus
F	0005886	cellular_component	plasma membrane
F	0006629	biological_process	lipid metabolic process
F	0009536	cellular_component	plastid
F	0016020	cellular_component	membrane
F	0016042	biological_process	lipid catabolic process
F	0016787	molecular_function	hydrolase activity
F	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
F	0017064	molecular_function	fatty acid amide hydrolase activity
F	0042742	biological_process	defense response to bacterium
F	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
F	0070291	biological_process	N-acylethanolamine metabolic process
G	0000325	cellular_component	plant-type vacuole
G	0003824	molecular_function	catalytic activity
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005794	cellular_component	Golgi apparatus
G	0005886	cellular_component	plasma membrane
G	0006629	biological_process	lipid metabolic process
G	0009536	cellular_component	plastid
G	0016020	cellular_component	membrane
G	0016042	biological_process	lipid catabolic process
G	0016787	molecular_function	hydrolase activity
G	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
G	0017064	molecular_function	fatty acid amide hydrolase activity
G	0042742	biological_process	defense response to bacterium
G	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
G	0070291	biological_process	N-acylethanolamine metabolic process
H	0000325	cellular_component	plant-type vacuole
H	0003824	molecular_function	catalytic activity
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005794	cellular_component	Golgi apparatus
H	0005886	cellular_component	plasma membrane
H	0006629	biological_process	lipid metabolic process
H	0009536	cellular_component	plastid
H	0016020	cellular_component	membrane
H	0016042	biological_process	lipid catabolic process
H	0016787	molecular_function	hydrolase activity
H	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
H	0017064	molecular_function	fatty acid amide hydrolase activity
H	0042742	biological_process	defense response to bacterium
H	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
H	0070291	biological_process	N-acylethanolamine metabolic process
I	0000325	cellular_component	plant-type vacuole
I	0003824	molecular_function	catalytic activity
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005794	cellular_component	Golgi apparatus
I	0005886	cellular_component	plasma membrane
I	0006629	biological_process	lipid metabolic process
I	0009536	cellular_component	plastid
I	0016020	cellular_component	membrane
I	0016042	biological_process	lipid catabolic process
I	0016787	molecular_function	hydrolase activity
I	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
I	0017064	molecular_function	fatty acid amide hydrolase activity
I	0042742	biological_process	defense response to bacterium
I	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
I	0070291	biological_process	N-acylethanolamine metabolic process
J	0000325	cellular_component	plant-type vacuole
J	0003824	molecular_function	catalytic activity
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0005794	cellular_component	Golgi apparatus
J	0005886	cellular_component	plasma membrane
J	0006629	biological_process	lipid metabolic process
J	0009536	cellular_component	plastid
J	0016020	cellular_component	membrane
J	0016042	biological_process	lipid catabolic process
J	0016787	molecular_function	hydrolase activity
J	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
J	0017064	molecular_function	fatty acid amide hydrolase activity
J	0042742	biological_process	defense response to bacterium
J	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
J	0070291	biological_process	N-acylethanolamine metabolic process
K	0000325	cellular_component	plant-type vacuole
K	0003824	molecular_function	catalytic activity
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0005794	cellular_component	Golgi apparatus
K	0005886	cellular_component	plasma membrane
K	0006629	biological_process	lipid metabolic process
K	0009536	cellular_component	plastid
K	0016020	cellular_component	membrane
K	0016042	biological_process	lipid catabolic process
K	0016787	molecular_function	hydrolase activity
K	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
K	0017064	molecular_function	fatty acid amide hydrolase activity
K	0042742	biological_process	defense response to bacterium
K	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
K	0070291	biological_process	N-acylethanolamine metabolic process
L	0000325	cellular_component	plant-type vacuole
L	0003824	molecular_function	catalytic activity
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0005794	cellular_component	Golgi apparatus
L	0005886	cellular_component	plasma membrane
L	0006629	biological_process	lipid metabolic process
L	0009536	cellular_component	plastid
L	0016020	cellular_component	membrane
L	0016042	biological_process	lipid catabolic process
L	0016787	molecular_function	hydrolase activity
L	0016811	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
L	0017064	molecular_function	fatty acid amide hydrolase activity
L	0042742	biological_process	defense response to bacterium
L	0047412	molecular_function	N-(long-chain-acyl)ethanolamine deacylase activity
L	0070291	biological_process	N-acylethanolamine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue GJY A 700

Chain	Residue
A	MET25
A	SER305
A	SER472
A	ILE475
A	ILE532
A	MET539
A	MET61
A	GLY255
A	THR258
A	SER281
A	ASP301
A	GLY302
A	GLY303
A	GLY304

site_id	AC2
Number of Residues	19
Details	binding site for Di-peptide GJY B 700 and SER B 305

Chain	Residue
B	MET25
B	MET61
B	GLY255
B	MET256
B	GLY257
B	THR258
B	GLY280
B	SER281
B	SER282
B	THR300
B	ASP301
B	GLY302
B	GLY303
B	GLY304
B	VAL306
B	PRO309
B	SER472
B	ILE475
B	ILE532

site_id	AC3
Number of Residues	20
Details	binding site for Di-peptide GJY C 700 and SER C 305

Chain	Residue
C	MET25
C	MET61
C	GLY255
C	GLY257
C	THR258
C	GLY280
C	SER281
C	SER282
C	THR300
C	ASP301
C	GLY302
C	GLY303
C	GLY304
C	VAL306
C	PRO309
C	SER472
C	ILE475
C	PHE476
C	ILE532
C	MET539

site_id	AC4
Number of Residues	18
Details	binding site for Di-peptide GJY D 700 and SER D 305

Chain	Residue
D	MET25
D	MET61
D	GLY255
D	GLY257
D	THR258
D	GLY280
D	SER281
D	SER282
D	THR300
D	GLY302
D	GLY303
D	GLY304
D	VAL306
D	PRO309
D	SER472
D	ILE475
D	ILE532
D	MET539

site_id	AC5
Number of Residues	20
Details	binding site for Di-peptide GJY E 700 and SER E 305

Chain	Residue
E	MET25
E	MET61
E	GLY255
E	GLY257
E	THR258
E	GLY280
E	SER281
E	SER282
E	THR300
E	ASP301
E	GLY302
E	GLY303
E	GLY304
E	VAL306
E	PRO309
E	SER472
E	ILE475
E	PHE476
E	ILE532
E	MET539

site_id	AC6
Number of Residues	18
Details	binding site for Di-peptide GJY F 700 and SER F 305

Chain	Residue
F	THR300
F	GLY302
F	GLY303
F	GLY304
F	VAL306
F	PRO309
F	SER472
F	ILE475
F	ILE532
F	MET539
F	MET25
F	MET61
F	GLY255
F	GLY257
F	THR258
F	GLY280
F	SER281
F	SER282

site_id	AC7
Number of Residues	18
Details	binding site for Di-peptide GJY G 700 and SER G 305

Chain	Residue
G	MET25
G	MET61
G	GLY255
G	THR258
G	GLY280
G	SER281
G	SER282
G	THR300
G	ASP301
G	GLY302
G	GLY303
G	GLY304
G	VAL306
G	PRO309
G	SER472
G	ILE475
G	ILE532
G	MET539

site_id	AC8
Number of Residues	19
Details	binding site for Di-peptide GJY H 700 and SER H 305

Chain	Residue
H	MET25
H	MET61
H	GLY255
H	THR258
H	GLY280
H	SER281
H	SER282
H	THR300
H	ASP301
H	GLY302
H	GLY303
H	GLY304
H	VAL306
H	PRO309
H	VAL442
H	SER472
H	ILE475
H	ILE532
H	MET539

site_id	AC9
Number of Residues	18
Details	binding site for Di-peptide GJY I 700 and SER I 305

Chain	Residue
I	MET25
I	MET61
I	GLY255
I	THR258
I	GLY280
I	SER281
I	SER282
I	THR300
I	ASP301
I	GLY302
I	GLY303
I	GLY304
I	VAL306
I	PRO309
I	SER472
I	ILE475
I	ILE532
I	MET539

site_id	AD1
Number of Residues	19
Details	binding site for Di-peptide GJY J 700 and SER J 305

Chain	Residue
J	MET25
J	MET61
J	GLY255
J	GLY257
J	THR258
J	GLY280
J	SER281
J	SER282
J	THR300
J	ASP301
J	GLY302
J	GLY303
J	GLY304
J	VAL306
J	PRO309
J	SER472
J	ILE475
J	ILE532
J	MET539

site_id	AD2
Number of Residues	18
Details	binding site for Di-peptide GJY K 700 and SER K 305

Chain	Residue
K	MET25
K	MET61
K	GLY255
K	THR258
K	GLY280
K	SER281
K	SER282
K	THR300
K	ASP301
K	GLY302
K	GLY303
K	GLY304
K	VAL306
K	PRO309
K	SER472
K	ILE475
K	ILE532
K	MET539

site_id	AD3
Number of Residues	19
Details	binding site for Di-peptide GJY L 700 and SER L 305

Chain	Residue
L	MET25
L	MET61
L	GLY255
L	GLY257
L	THR258
L	GLY280
L	SER281
L	SER282
L	THR300
L	ASP301
L	GLY302
L	GLY303
L	GLY304
L	VAL306
L	PRO309
L	SER472
L	ILE475
L	ILE532
L	MET539

Functional Information from PROSITE/UniProt

site_id	PS00571
Number of Residues	32
Details	AMIDASES Amidases signature. GGSSSGsAAiVAaglcsaAlGtDgGgSVRiPS

Chain	Residue	Details
A	GLY279-SER310

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"19801664","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"19801664","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30894416","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DII","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)