6DHJ
Crystal structures of cyanuric acid hydrolase from Moorella thermoacetica
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| A | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| A | 0019381 | biological_process | atrazine catabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| B | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| B | 0019381 | biological_process | atrazine catabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| C | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| C | 0019381 | biological_process | atrazine catabolic process |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| D | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| D | 0019381 | biological_process | atrazine catabolic process |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| E | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| E | 0019381 | biological_process | atrazine catabolic process |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| F | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| F | 0019381 | biological_process | atrazine catabolic process |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| G | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| G | 0019381 | biological_process | atrazine catabolic process |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0016812 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides |
| H | 0018753 | molecular_function | cyanuric acid amidohydrolase activity |
| H | 0019381 | biological_process | atrazine catabolic process |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CIT A 401 |
| Chain | Residue |
| A | GLY45 |
| A | GLY348 |
| A | ARG52 |
| A | SER83 |
| A | GLY84 |
| A | ARG193 |
| A | SER231 |
| A | ALA232 |
| A | ARG328 |
| A | SER347 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CIT F 401 |
| Chain | Residue |
| F | GLY45 |
| F | ARG52 |
| F | SER83 |
| F | GLY84 |
| F | ARG193 |
| F | SER231 |
| F | ALA232 |
| F | ARG328 |
| F | SER347 |
| F | GLY348 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide CIT B 401 and GLY B 84 |
| Chain | Residue |
| B | LYS40 |
| B | THR41 |
| B | GLY45 |
| B | ARG52 |
| B | SER83 |
| B | GLY85 |
| B | ARG193 |
| B | SER231 |
| B | ALA232 |
| B | ARG328 |
| B | SER347 |
| B | GLY348 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide CIT C 401 and GLY C 84 |
| Chain | Residue |
| C | LYS40 |
| C | THR41 |
| C | GLY45 |
| C | ARG52 |
| C | SER83 |
| C | GLY85 |
| C | ARG193 |
| C | SER231 |
| C | ALA232 |
| C | ARG328 |
| C | GLY348 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide CIT D 401 and ARG D 328 |
| Chain | Residue |
| D | ASN44 |
| D | GLY45 |
| D | ARG52 |
| D | SER83 |
| D | GLY84 |
| D | GLY85 |
| D | GLU87 |
| D | ARG193 |
| D | SER231 |
| D | ALA232 |
| D | THR324 |
| D | ARG325 |
| D | SER326 |
| D | ALA327 |
| D | ALA329 |
| D | VAL330 |
| D | VAL331 |
| D | ASN332 |
| D | SER347 |
| D | GLY348 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide CIT D 401 and GLY D 348 |
| Chain | Residue |
| D | GLY45 |
| D | ARG52 |
| D | SER83 |
| D | GLY84 |
| D | ARG193 |
| D | SER231 |
| D | ALA232 |
| D | LYS299 |
| D | ALA300 |
| D | ARG328 |
| D | SER347 |
| D | GLY349 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide CIT E 401 and GLY E 45 |
| Chain | Residue |
| E | GLY43 |
| E | ASN44 |
| E | SER46 |
| E | ASP49 |
| E | ARG52 |
| E | SER83 |
| E | GLY84 |
| E | SER231 |
| E | ALA232 |
| E | ARG328 |
| E | SER347 |
| E | GLY348 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | binding site for Di-peptide CIT E 401 and ARG E 328 |
| Chain | Residue |
| E | ALA327 |
| E | ALA329 |
| E | VAL330 |
| E | VAL331 |
| E | ASN332 |
| E | VAL346 |
| E | SER347 |
| E | GLY348 |
| E | GLY45 |
| E | SER46 |
| E | ASP49 |
| E | ARG52 |
| E | SER83 |
| E | GLY84 |
| E | GLU87 |
| E | SER231 |
| E | ALA232 |
| E | THR324 |
| E | ARG325 |
| E | SER326 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide CIT G 401 and ARG G 193 |
| Chain | Residue |
| G | GLY45 |
| G | ARG52 |
| G | SER83 |
| G | GLY84 |
| G | MET189 |
| G | ALA190 |
| G | TYR191 |
| G | SER192 |
| G | GLY194 |
| G | ALA195 |
| G | SER196 |
| G | ALA197 |
| G | THR230 |
| G | SER231 |
| G | ALA232 |
| G | ARG328 |
| G | GLY348 |
| G | GLU351 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide ALA H 162 and ASN H 238 |
| Chain | Residue |
| H | LYS161 |
| H | PRO163 |
| H | LEU164 |
| H | SER196 |
| H | SER231 |
| H | ALA232 |
| H | LEU236 |
| H | LEU237 |
| H | ASP239 |
| H | GLU240 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide PRO H 163 and ASN H 238 |
| Chain | Residue |
| H | LYS161 |
| H | ALA162 |
| H | LEU164 |
| H | SER192 |
| H | LEU236 |
| H | LEU237 |
| H | ASP239 |
| H | GLU240 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for Di-peptide PRO H 163 and ASN H 238 |
| Chain | Residue |
| H | LYS161 |
| H | ALA162 |
| H | LEU164 |
| H | SER192 |
| H | LEU236 |
| H | LEU237 |
| H | ASP239 |
| H | GLU240 |
| site_id | AD4 |
| Number of Residues | 19 |
| Details | binding site for Di-peptide CIT H 401 and ARG H 328 |
| Chain | Residue |
| H | ASN44 |
| H | GLY45 |
| H | ARG52 |
| H | SER83 |
| H | GLY84 |
| H | GLY85 |
| H | GLU87 |
| H | ARG193 |
| H | SER231 |
| H | THR324 |
| H | ARG325 |
| H | SER326 |
| H | ALA327 |
| H | ALA329 |
| H | VAL330 |
| H | VAL331 |
| H | ASN332 |
| H | SER347 |
| H | GLY348 |
| site_id | AD5 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide CIT H 401 and GLY H 348 |
| Chain | Residue |
| H | GLY45 |
| H | ARG52 |
| H | SER83 |
| H | GLY84 |
| H | ARG193 |
| H | SER231 |
| H | LYS299 |
| H | ARG328 |
| H | SER347 |
| H | GLY349 |
| site_id | AD6 |
| Number of Residues | 18 |
| Details | binding site for Di-peptide CIT H 401 and ARG H 52 |
| Chain | Residue |
| H | THR41 |
| H | GLY45 |
| H | SER46 |
| H | ASP49 |
| H | PHE50 |
| H | THR51 |
| H | CYS53 |
| H | PHE54 |
| H | ALA55 |
| H | THR56 |
| H | MET82 |
| H | SER83 |
| H | GLY84 |
| H | ARG193 |
| H | SER231 |
| H | ARG328 |
| H | SER347 |
| H | GLY348 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 824 |
| Details | Region: {"description":"RU A","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 822 |
| Details | Region: {"description":"RU B","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 96 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Important for substrate specificity","evidences":[{"source":"HAMAP-Rule","id":"MF_01989","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
