6DFO

Crystal structure of human GRP78 in complex with 8-bromoadenosine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0140662	molecular_function	ATP-dependent protein folding chaperone
B	0005524	molecular_function	ATP binding
B	0140662	molecular_function	ATP-dependent protein folding chaperone

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GBA A 501

Chain	Residue
A	ILE61
A	ILE368
A	HOH630
A	GLY255
A	GLU293
A	LYS296
A	ARG297
A	SER300
A	GLY364
A	SER365
A	ARG367

---

site_id	AC2
Number of Residues	12
Details	binding site for residue GBA B 501

Chain	Residue
B	ILE61
B	GLY227
B	GLY255
B	GLU293
B	LYS296
B	ARG297
B	SER300
B	GLY364
B	SER365
B	ARG367
B	ILE368
B	HOH620

---

Functional Information from PROSITE/UniProt

site_id	PS00297
Number of Residues	8
Details	HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS

Chain	Residue	Details
A	ILE33-SER40

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site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. VFDLGGGTfdvSLL

Chain	Residue	Details
A	VAL222-LEU235

---

site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. IvLvGGsTRIPkIqQ

Chain	Residue	Details
A	ILE359-GLN373

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|PubMed:21526763

Chain	Residue	Details
A	GLY36
B	GLY364
A	LYS96
A	GLY227
A	GLU293
A	GLY364
B	GLY36
B	LYS96
B	GLY227
B	GLU293

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06761

Chain	Residue	Details
A	SER86
B	SER86

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P20029

Chain	Residue	Details
A	LYS125
A	LYS213
A	LYS326
B	LYS125
B	LYS213
B	LYS326

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P20029

Chain	Residue	Details
A	TYR160
B	TYR160

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DMV8

Chain	Residue	Details
A	LYS271
B	LYS271

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P20029

Chain	Residue	Details
A	LYS353
B	LYS353

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733

Chain	Residue	Details
A	LYS352
B	LYS352

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate => ECO:0007744|PubMed:25114211

Chain	Residue	Details
A	LYS353
B	LYS353

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