Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0044281 | biological_process | small molecule metabolic process |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | binding site for residue NDP A 201 |
| Chain | Residue |
| A | TRP6 |
| A | ARG45 |
| A | THR46 |
| A | LEU65 |
| A | SER66 |
| A | ARG67 |
| A | GLN68 |
| A | GLY80 |
| A | ILE94 |
| A | GLY96 |
| A | GLY97 |
| A | ALA7 |
| A | GLN98 |
| A | VAL99 |
| A | TYR100 |
| A | LEU102 |
| A | ALA126 |
| A | G7D202 |
| A | GOL203 |
| A | GOL204 |
| A | HOH322 |
| A | HOH323 |
| A | ILE14 |
| A | HOH332 |
| A | HOH338 |
| A | HOH357 |
| A | HOH371 |
| A | HOH395 |
| A | GLY15 |
| A | GLY18 |
| A | ASP19 |
| A | ILE20 |
| A | GLY43 |
| A | ARG44 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | binding site for residue G7D A 202 |
| Chain | Residue |
| A | ILE5 |
| A | TRP6 |
| A | ALA7 |
| A | ILE20 |
| A | ASP27 |
| A | GLN28 |
| A | ALA29 |
| A | PHE31 |
| A | ARG32 |
| A | LEU50 |
| A | PRO51 |
| A | VAL54 |
| A | LEU57 |
| A | ARG60 |
| A | ILE94 |
| A | NDP201 |
| A | HOH307 |
| A | HOH308 |
| A | HOH311 |
| A | HOH361 |
| A | HOH363 |
| A | HOH383 |
| A | HOH398 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 203 |
| Chain | Residue |
| A | ARG45 |
| A | GLN98 |
| A | GLY124 |
| A | ASP125 |
| A | ALA126 |
| A | GLY148 |
| A | LEU149 |
| A | NDP201 |
| A | HOH313 |
| A | HOH325 |
| A | HOH341 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | GLY15 |
| A | ARG16 |
| A | GLY17 |
| A | GLY18 |
| A | ARG45 |
| A | GLY124 |
| A | NDP201 |
| A | HOH312 |
| A | HOH350 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 205 |
| Chain | Residue |
| A | ARG121 |
| A | TRP142 |
| A | ARG152 |
| A | HOH394 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 206 |
| Chain | Residue |
| A | GLN8 |
| A | GLU114 |
| A | TYR156 |
| A | HOH301 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 207 |
| Chain | Residue |
| A | ARG44 |
| A | ARG45 |
| A | HOH312 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWrlpe.DqahFreiT |
| Chain | Residue | Details |
| A | VAL13-THR35 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Binding site: {} |
