6DDI
Crystal Structure of the human BRD2 BD1 bromodomain in complex with a Tetrahydroquinoline analogue
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue G7V A 301 |
| Chain | Residue |
| A | TRP97 |
| A | HOH456 |
| A | HOH466 |
| A | HOH480 |
| B | GLN94 |
| A | PRO98 |
| A | PHE99 |
| A | LYS107 |
| A | LEU108 |
| A | LEU110 |
| A | CYS152 |
| A | ASN156 |
| A | HOH412 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG100 |
| A | HOH408 |
| A | HOH446 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ASP160 |
| A | ASP161 |
| A | ILE162 |
| A | HOH464 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | GLN94 |
| A | TRP97 |
| B | GLN94 |
| B | TRP97 |
| B | MET165 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue G7V B 301 |
| Chain | Residue |
| A | GLN94 |
| B | TRP97 |
| B | PRO98 |
| B | PHE99 |
| B | LEU110 |
| B | CYS152 |
| B | ASN156 |
| B | HOH413 |
| B | HOH445 |
| B | HOH448 |
| B | HOH460 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue 03S B 302 |
| Chain | Residue |
| B | TRP97 |
| B | ARG100 |
| B | HOH407 |
| B | HOH424 |
| B | HOH462 |
| C | ASN132 |
| C | TYR134 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | ASP160 |
| B | ASP161 |
| B | ILE162 |
| B | HOH403 |
| B | HOH409 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue G7V C 301 |
| Chain | Residue |
| A | GLN80 |
| A | LYS84 |
| A | PRO181 |
| C | TRP97 |
| C | PRO98 |
| C | GLN101 |
| C | LEU110 |
| C | ASN156 |
| C | HOH407 |
| C | HOH439 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFrqpvDavklglpDYHkiIkqpMdmgtIkrrlenny..Ywaasecmqdfnt.MftNCyiY |
| Chain | Residue | Details |
| A | ALA96-TYR155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 106 |
| Details | Domain: {"description":"Bromo 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37731000","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8SB6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20048151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2DVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DVS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
