6DCV

Crystal structure of human anti-tau antibody CBTAU-27.1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002250	biological_process	adaptive immune response
A	0003823	molecular_function	antigen binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005886	cellular_component	plasma membrane
A	0006955	biological_process	immune response
A	0016064	biological_process	immunoglobulin mediated immune response
A	0019814	cellular_component	immunoglobulin complex
A	0050853	biological_process	B cell receptor signaling pathway
A	0070062	cellular_component	extracellular exosome
A	0071735	cellular_component	IgG immunoglobulin complex
A	0071738	cellular_component	IgD immunoglobulin complex
A	0071742	cellular_component	IgE immunoglobulin complex
A	0071745	cellular_component	IgA immunoglobulin complex
A	0071753	cellular_component	IgM immunoglobulin complex
A	0072562	cellular_component	blood microparticle
L	0002250	biological_process	adaptive immune response
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue GOL H 301

Chain	Residue
H	PHE174
H	PRO175
H	SER186
H	LEU187
H	SER188
L	SER176
L	THR178

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site_id	AC2
Number of Residues	5
Details	binding site for residue GOL H 302

Chain	Residue
H	HOH402
H	HOH404
L	LYS207
H	SER85
H	LYS129

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site_id	AC3
Number of Residues	7
Details	binding site for residue GOL B 301

Chain	Residue
A	SER176
A	THR178
B	PHE174
B	PRO175
B	SER186
B	LEU187
B	SER188

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR206-HIS212
L	TYR192-HIS198

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