6D9Q

The sulfate-bound crystal structure of HPRT (hypoxanthine phosphoribosyltransferase)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 201

Chain	Residue
A	LEU42
A	LYS43
A	GLY44
A	ASP159
A	ARG165
A	HOH325
A	HOH376

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 202

Chain	Residue
A	GLY105
A	HOH303
A	HOH318
A	ASP103
A	SER104

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 B 201

Chain	Residue
B	ASP103
B	SER104
B	GLY105
B	HOH319
B	HOH353
B	HOH368

---

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 B 202

Chain	Residue
B	LYS43
B	GLY44
B	ASP159
B	ARG165
B	HOH302
B	HOH336
B	HOH338

---

site_id	AC5
Number of Residues	6
Details	binding site for residue SO4 C 201

Chain	Residue
C	LEU42
C	LYS43
C	GLY44
C	ASP159
C	ARG165
C	HOH319

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 C 202

Chain	Residue
C	ASP103
C	SER104
C	GLY105
C	HOH301
C	HOH307
C	HOH336
C	HOH367

---

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 D 201

Chain	Residue
D	ASP103
D	SER104
D	GLY105
D	HOH302
D	HOH311
D	HOH322
D	HOH337

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 D 202

Chain	Residue
D	LEU42
D	LYS43
D	GLY44
D	ASP159
D	ARG165
D	HOH304

---

site_id	AC9
Number of Residues	2
Details	binding site for residue GOL D 203

Chain	Residue
D	VAL9
D	TYR169

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Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. ILIVEDIIDSGlT

Chain	Residue	Details
A	ILE95-THR107

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