6D97

Structure of aldehyde dehydrogenase 12 (ALDH12) from Zea mays

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005739	cellular_component	mitochondrion
A	0010133	biological_process	proline catabolic process to glutamate
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0000166	molecular_function	nucleotide binding
B	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005739	cellular_component	mitochondrion
B	0010133	biological_process	proline catabolic process to glutamate
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0000166	molecular_function	nucleotide binding
C	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0005739	cellular_component	mitochondrion
C	0010133	biological_process	proline catabolic process to glutamate
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0000166	molecular_function	nucleotide binding
D	0003842	molecular_function	1-pyrroline-5-carboxylate dehydrogenase activity
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0005739	cellular_component	mitochondrion
D	0010133	biological_process	proline catabolic process to glutamate
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue NAD A 601

Chain	Residue
A	ILE197
A	LEU284
A	HOH729
A	HOH735
A	THR198
A	LYS224
A	ASP226
A	GLY257
A	ASN261
A	PHE274
A	SER277
A	VAL280

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site_id	AC2
Number of Residues	11
Details	binding site for residue NAD B 601

Chain	Residue
B	ILE197
B	THR198
B	LYS224
B	ASP226
B	GLY257
B	ASN261
B	PHE274
B	SER277
B	VAL280
B	LEU284
B	HOH703

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site_id	AC3
Number of Residues	12
Details	binding site for residue NAD C 601

Chain	Residue
C	ILE197
C	THR198
C	PHE200
C	LYS224
C	ASP226
C	GLY257
C	ASN261
C	PHE274
C	GLY276
C	SER277
C	VAL280
C	HOH823

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site_id	AC4
Number of Residues	12
Details	binding site for residue NAD D 601

Chain	Residue
D	ILE197
D	THR198
D	LYS224
D	ASP226
D	GLY257
D	ASN261
D	PHE274
D	SER277
D	VAL280
D	HOH701
D	HOH796
D	HOH811

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Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YaCSGQKCSAQS

Chain	Residue	Details
A	TYR323-SER334

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site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. LLEANPKM

Chain	Residue	Details
A	LEU264-MET271

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