6D7O
Crystal Structure of Rat TRPV6* in complex with 2-Aminoethoxydiphenyl borate (2-APB)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 701 |
| Chain | Residue |
| A | ASP541 |
| A | ASP541 |
| A | ASP541 |
| A | ASP541 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue FZ4 A 702 |
| Chain | Residue |
| A | ASN463 |
| A | TYR466 |
| A | ARG469 |
| A | MET602 |
| A | VAL401 |
| A | GLU402 |
| A | PHE424 |
| A | HIS425 |
| A | ILE428 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue DTB A 703 |
| Chain | Residue |
| A | ARG33 |
| A | GLN40 |
| A | LEU88 |
| A | MET110 |
| A | TYR115 |
| A | ILE123 |
| A | VAL151 |
| A | ILE160 |
| A | TRP267 |
| A | TYR269 |
| A | LEU272 |
| A | GLU633 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 100 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27296226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28878326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 63 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27296226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28878326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 19 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"27296226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28878326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"27296226","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28878326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"ANK 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ANK 5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 29 |
| Details | Repeat: {"description":"ANK 6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with calmodulin","evidences":[{"source":"UniProtKB","id":"Q91WD2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with S100A10","evidences":[{"source":"UniProtKB","id":"Q91WD2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"27296226","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27296226","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IWK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IWP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"17197020","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
