6D7J
The Crystal Structure of Parabacteroides merdae Beta-Glucuronidase (GUS) with Glycerol in Active-Site
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| D | 0005975 | biological_process | carbohydrate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue K A 901 |
| Chain | Residue |
| A | ASP78 |
| A | ALA79 |
| A | ASP81 |
| A | VAL84 |
| A | TYR608 |
| A | HOH1211 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 902 |
| Chain | Residue |
| A | ARG172 |
| A | HOH1120 |
| B | LYS41 |
| B | ASP43 |
| B | PRO63 |
| A | TYR86 |
| A | TYR87 |
| A | GLU88 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 903 |
| Chain | Residue |
| A | VAL123 |
| A | TYR124 |
| A | THR125 |
| A | THR126 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 904 |
| Chain | Residue |
| A | PHE228 |
| A | TYR229 |
| A | ASN230 |
| A | PRO231 |
| A | LEU262 |
| A | GLY263 |
| D | ALA447 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 905 |
| Chain | Residue |
| A | ASN101 |
| A | GLY106 |
| A | ILE108 |
| A | LYS147 |
| A | HOH1039 |
| A | HOH1150 |
| C | GLY491 |
| C | VAL492 |
| C | ASP495 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 906 |
| Chain | Residue |
| A | VAL128 |
| A | ASP141 |
| A | ILE142 |
| A | ASP144 |
| A | ALA145 |
| A | HOH1041 |
| A | HOH1086 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 907 |
| Chain | Residue |
| A | HIS367 |
| A | ARG393 |
| A | ASN429 |
| A | GLU430 |
| A | ARG468 |
| A | GLU514 |
| A | TRP591 |
| A | HOH1024 |
| A | HOH1106 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 908 |
| Chain | Residue |
| A | ASP264 |
| A | GLN265 |
| A | HOH1299 |
| D | LYS450 |
| D | HIS453 |
| D | ASP454 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 909 |
| Chain | Residue |
| A | ARG523 |
| A | GLY561 |
| A | TRP563 |
| A | GLN793 |
| A | HOH1026 |
| A | HOH1138 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 910 |
| Chain | Residue |
| A | ASP441 |
| A | SER443 |
| A | HOH1233 |
| D | PRO231 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 911 |
| Chain | Residue |
| A | GLU232 |
| A | ARG235 |
| A | GOL912 |
| A | HOH1022 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 912 |
| Chain | Residue |
| A | PRO231 |
| A | GLU232 |
| A | GOL911 |
| A | HOH1022 |
| D | SER443 |
| D | GOL903 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 913 |
| Chain | Residue |
| A | LYS41 |
| A | ASP78 |
| A | VAL84 |
| A | ASN85 |
| B | LYS41 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue PRO A 914 |
| Chain | Residue |
| A | LEU209 |
| A | GLU210 |
| A | SER211 |
| A | PHE305 |
| A | GLY306 |
| A | HIS417 |
| A | ASN418 |
| A | PRO420 |
| A | HOH1027 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 915 |
| Chain | Residue |
| A | ASP173 |
| A | MET176 |
| A | PRO178 |
| A | HOH1113 |
| A | HOH1271 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue K B 901 |
| Chain | Residue |
| B | TYR608 |
| B | HOH1195 |
| B | ASP78 |
| B | ALA79 |
| B | ASP81 |
| B | VAL84 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 902 |
| Chain | Residue |
| B | SER483 |
| B | ILE484 |
| B | TRP485 |
| B | TYR489 |
| B | ARG490 |
| B | HOH1138 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 903 |
| Chain | Residue |
| B | LEU96 |
| B | LEU97 |
| B | ALA98 |
| B | HOH1025 |
| B | HOH1118 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 904 |
| Chain | Residue |
| B | ARG107 |
| B | ASP141 |
| B | TYR229 |
| site_id | AE2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 905 |
| Chain | Residue |
| B | PHE228 |
| B | TYR229 |
| B | ASN230 |
| B | LEU262 |
| B | GLY263 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 906 |
| Chain | Residue |
| B | LYS30 |
| B | ARG32 |
| B | ASP113 |
| B | ASN195 |
| site_id | AE4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 907 |
| Chain | Residue |
| B | ASP183 |
| B | HIS367 |
| B | ASN429 |
| B | ARG468 |
| B | GLU514 |
| B | TRP591 |
| B | HOH1033 |
| B | HOH1246 |
| B | HOH1251 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 908 |
| Chain | Residue |
| B | ARG523 |
| B | GLY561 |
| B | PRO605 |
| B | LYS766 |
| B | GLN793 |
| site_id | AE6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL B 909 |
| Chain | Residue |
| A | LYS41 |
| A | GLY42 |
| A | ASP43 |
| A | PRO63 |
| B | ASN85 |
| B | TYR86 |
| B | TYR87 |
| B | GLU88 |
| B | HOH1110 |
| B | HOH1193 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 910 |
| Chain | Residue |
| A | ASN85 |
| B | TYR39 |
| B | LEU40 |
| B | LYS41 |
| B | ILE64 |
| B | TRP65 |
| B | GLN66 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 911 |
| Chain | Residue |
| B | LEU209 |
| B | SER211 |
| B | GLY306 |
| B | HIS417 |
| B | ASN418 |
| B | PRO420 |
| B | ARG463 |
| B | HOH1074 |
| B | HOH1333 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 912 |
| Chain | Residue |
| B | THR310 |
| B | GLU311 |
| B | PHE312 |
| B | THR462 |
| B | MET464 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 913 |
| Chain | Residue |
| A | HOH1023 |
| B | TRP433 |
| B | ARG469 |
| B | HOH1241 |
| site_id | AF2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 914 |
| Chain | Residue |
| B | GLN726 |
| B | ILE760 |
| B | ARG761 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 915 |
| Chain | Residue |
| B | CYS736 |
| B | GLN737 |
| B | VAL738 |
| B | HOH1124 |
| B | HOH1292 |
| B | HOH1319 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue GOL B 916 |
| Chain | Residue |
| B | LYS767 |
| B | GLN768 |
| B | GLU817 |
| B | HOH1015 |
| site_id | AF5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 917 |
| Chain | Residue |
| B | ALA23 |
| B | VAL25 |
| B | ASN139 |
| B | GLU205 |
| B | TYR229 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 918 |
| Chain | Residue |
| B | ASP173 |
| B | MET176 |
| B | PRO178 |
| B | SER179 |
| B | HOH1057 |
| B | HOH1248 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue K C 901 |
| Chain | Residue |
| C | ASP78 |
| C | ALA79 |
| C | ASP81 |
| C | VAL84 |
| C | TYR608 |
| C | HOH1234 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 902 |
| Chain | Residue |
| C | ARG107 |
| C | ASP144 |
| C | GLU232 |
| C | HOH1020 |
| site_id | AF9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 903 |
| Chain | Residue |
| C | ARG523 |
| C | GLY561 |
| C | TRP563 |
| C | ASP603 |
| C | LYS766 |
| C | GLN793 |
| site_id | AG1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 904 |
| Chain | Residue |
| C | LEU40 |
| C | GLY42 |
| C | ASP43 |
| C | PRO63 |
| C | HOH1024 |
| C | HOH1097 |
| D | TYR86 |
| D | TYR87 |
| D | GLU88 |
| site_id | AG2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 905 |
| Chain | Residue |
| C | ASP527 |
| C | ALA528 |
| C | PRO555 |
| C | ARG556 |
| C | SER558 |
| C | TYR567 |
| C | HOH1022 |
| site_id | AG3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 906 |
| Chain | Residue |
| C | GLU49 |
| C | ALA50 |
| C | ARG52 |
| C | ALA54 |
| C | LYS94 |
| C | HOH1040 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 907 |
| Chain | Residue |
| C | PHE228 |
| C | TYR229 |
| C | ASN230 |
| C | LEU262 |
| C | GLY263 |
| C | HOH1116 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 908 |
| Chain | Residue |
| C | VAL109 |
| C | ASN139 |
| C | TYR229 |
| site_id | AG6 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 909 |
| Chain | Residue |
| C | ASP183 |
| C | HIS367 |
| C | ASN429 |
| C | ARG468 |
| C | GLU514 |
| C | TRP591 |
| C | HOH1075 |
| C | HOH1118 |
| C | HOH1179 |
| site_id | AG7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 910 |
| Chain | Residue |
| C | HIS524 |
| C | SER525 |
| C | GLU526 |
| C | ASP527 |
| C | ASP562 |
| site_id | AG8 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 911 |
| Chain | Residue |
| C | LYS24 |
| C | LYS30 |
| C | ARG32 |
| C | ASP111 |
| C | ASP113 |
| C | GLU372 |
| C | HOH1036 |
| C | HOH1063 |
| site_id | AG9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL C 912 |
| Chain | Residue |
| C | LEU209 |
| C | GLU210 |
| C | SER211 |
| C | PHE305 |
| C | GLY306 |
| C | ASN418 |
| C | PRO420 |
| C | ARG463 |
| C | HOH1221 |
| site_id | AH1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 913 |
| Chain | Residue |
| C | ARG349 |
| C | ASP376 |
| C | LEU377 |
| C | GLU380 |
| C | HOH1047 |
| C | HOH1243 |
| site_id | AH2 |
| Number of Residues | 8 |
| Details | binding site for residue GOL C 914 |
| Chain | Residue |
| C | TYR86 |
| C | TYR87 |
| C | GLU88 |
| C | HOH1105 |
| C | HOH1175 |
| D | GLY42 |
| D | ASP43 |
| D | PRO63 |
| site_id | AH3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 915 |
| Chain | Residue |
| C | LYS679 |
| C | ARG692 |
| C | ASN694 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 916 |
| Chain | Residue |
| C | LYS24 |
| C | GLU303 |
| C | ARG304 |
| C | GLU372 |
| C | ASP376 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 917 |
| Chain | Residue |
| C | VAL128 |
| C | ASP141 |
| C | ILE142 |
| C | ASP144 |
| C | ALA145 |
| C | HOH1249 |
| site_id | AH6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 918 |
| Chain | Residue |
| C | TRP433 |
| C | PRO434 |
| C | HOH1009 |
| C | HOH1057 |
| D | HOH1106 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 919 |
| Chain | Residue |
| C | ASP173 |
| C | MET176 |
| C | PRO178 |
| C | HOH1099 |
| C | HOH1267 |
| site_id | AH8 |
| Number of Residues | 6 |
| Details | binding site for residue K D 901 |
| Chain | Residue |
| D | ASP78 |
| D | ALA79 |
| D | ASP81 |
| D | VAL84 |
| D | TYR608 |
| D | HOH1254 |
| site_id | AH9 |
| Number of Residues | 12 |
| Details | binding site for residue GOL D 902 |
| Chain | Residue |
| D | ASP183 |
| D | HIS367 |
| D | ARG393 |
| D | ASN429 |
| D | GLU430 |
| D | ARG468 |
| D | GLU514 |
| D | TRP591 |
| D | ASN610 |
| D | HOH1025 |
| D | HOH1129 |
| D | HOH1184 |
| site_id | AI1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 903 |
| Chain | Residue |
| A | PRO231 |
| A | GOL912 |
| D | ASP441 |
| D | SER443 |
| D | ALA444 |
| site_id | AI2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 904 |
| Chain | Residue |
| D | ASN139 |
| D | GLU205 |
| D | TYR229 |
| site_id | AI3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL D 905 |
| Chain | Residue |
| D | LEU209 |
| D | SER211 |
| D | PHE305 |
| D | GLY306 |
| D | ASN418 |
| D | PRO420 |
| D | HOH1232 |
| site_id | AI4 |
| Number of Residues | 1 |
| Details | binding site for residue GOL D 906 |
| Chain | Residue |
| D | LYS269 |
| site_id | AI5 |
| Number of Residues | 3 |
| Details | binding site for residue GOL D 907 |
| Chain | Residue |
| D | ARG350 |
| D | ASP618 |
| D | THR620 |
| site_id | AI6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 908 |
| Chain | Residue |
| A | SER443 |
| D | PRO231 |
| D | GLU232 |
| D | HOH1016 |
| site_id | AI7 |
| Number of Residues | 9 |
| Details | binding site for residue GOL D 909 |
| Chain | Residue |
| C | ASN85 |
| D | TYR39 |
| D | LEU40 |
| D | LYS41 |
| D | ILE64 |
| D | GLN66 |
| D | HOH1031 |
| D | HOH1116 |
| D | HOH1272 |
| site_id | AI8 |
| Number of Residues | 3 |
| Details | binding site for residue PRO D 910 |
| Chain | Residue |
| D | GLU501 |
| D | GLN505 |
| D | TRP584 |
| site_id | AI9 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 911 |
| Chain | Residue |
| D | ASP173 |
| D | MET176 |
| D | PRO178 |
| D | HOH1050 |
| D | HOH1229 |
