6D66
Crystal structure of the human dual specificity 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein mbp3_16
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| A | 0015768 | biological_process | maltose transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0034219 | biological_process | carbohydrate transmembrane transport |
| A | 0034289 | biological_process | detection of maltose stimulus |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042956 | biological_process | maltodextrin transmembrane transport |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0071702 | biological_process | organic substance transport |
| A | 1901982 | molecular_function | maltose binding |
| A | 1990060 | cellular_component | maltose transport complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue PEG A 1401 |
| Chain | Residue |
| A | GLU154 |
| A | EDO1407 |
| A | EDO1419 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 A 1402 |
| Chain | Residue |
| A | SER463 |
| A | ARG464 |
| A | HOH1649 |
| A | ASP427 |
| A | SER458 |
| A | GLN459 |
| A | ALA460 |
| A | GLY461 |
| A | ILE462 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue GLY A 1403 |
| Chain | Residue |
| A | ALA325 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue PGE A 1404 |
| Chain | Residue |
| A | TYR91 |
| A | GLN326 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1405 |
| Chain | Residue |
| A | LYS430 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1406 |
| Chain | Residue |
| A | GLN419 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1407 |
| Chain | Residue |
| A | ASP66 |
| A | MET331 |
| A | PEG1401 |
| A | HOH1506 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue PG4 A 1408 |
| Chain | Residue |
| A | ALA84 |
| A | GLN87 |
| B | LYS68 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1409 |
| Chain | Residue |
| A | ASN350 |
| A | ARG355 |
| A | ARG453 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1410 |
| Chain | Residue |
| A | SER496 |
| A | PRO497 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue PGE A 1411 |
| Chain | Residue |
| A | LYS128 |
| A | SER390 |
| A | LYS392 |
| A | ASP393 |
| A | PHE414 |
| A | HOH1536 |
| A | HOH1686 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue GLY A 1412 |
| Chain | Residue |
| A | ASP482 |
| A | MET502 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue GLY A 1413 |
| Chain | Residue |
| A | SER435 |
| A | GLU439 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1414 |
| Chain | Residue |
| A | ASP96 |
| A | TYR177 |
| A | ILE330 |
| A | HOH1513 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue PGE A 1415 |
| Chain | Residue |
| A | ASN283 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1416 |
| Chain | Residue |
| A | GLU292 |
| A | TYR308 |
| A | HIS519 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 1417 |
| Chain | Residue |
| A | GLU279 |
| A | GLU282 |
| A | HOH1545 |
| B | ASN36 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1418 |
| Chain | Residue |
| A | ASP427 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1419 |
| Chain | Residue |
| A | PEG1401 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 201 |
| Chain | Residue |
| A | TYR387 |
| A | GLN459 |
| B | ASP122 |
| B | HOH363 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 202 |
| Chain | Residue |
| B | HIS23 |
| site_id | AE4 |
| Number of Residues | 2 |
| Details | binding site for residue PEG B 203 |
| Chain | Residue |
| B | GLU64 |
| B | LYS101 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue DAL B 204 |
| Chain | Residue |
| A | ALA85 |
| B | ARG31 |
| B | TYR69 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 205 |
| Chain | Residue |
| B | GLN26 |
| B | ASP27 |
| B | ASP28 |
| B | GLU29 |
Functional Information from PROSITE/UniProt
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| A | PRO108-ASN125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 |
| Chain | Residue | Details |
| A | SER458 |
