6D66

Crystal structure of the human dual specificity 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein mbp3_16

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0006470	biological_process	protein dephosphorylation
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016311	biological_process	dephosphorylation
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	1901982	molecular_function	maltose binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PEG A 1401

Chain	Residue
A	GLU154
A	EDO1407
A	EDO1419

---

site_id	AC2
Number of Residues	9
Details	binding site for residue PO4 A 1402

Chain	Residue
A	SER463
A	ARG464
A	HOH1649
A	ASP427
A	SER458
A	GLN459
A	ALA460
A	GLY461
A	ILE462

---

site_id	AC3
Number of Residues	1
Details	binding site for residue GLY A 1403

Chain	Residue
A	ALA325

---

site_id	AC4
Number of Residues	2
Details	binding site for residue PGE A 1404

Chain	Residue
A	TYR91
A	GLN326

---

site_id	AC5
Number of Residues	1
Details	binding site for residue EDO A 1405

Chain	Residue
A	LYS430

---

site_id	AC6
Number of Residues	1
Details	binding site for residue EDO A 1406

Chain	Residue
A	GLN419

---

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO A 1407

Chain	Residue
A	ASP66
A	MET331
A	PEG1401
A	HOH1506

---

site_id	AC8
Number of Residues	3
Details	binding site for residue PG4 A 1408

Chain	Residue
A	ALA84
A	GLN87
B	LYS68

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO A 1409

Chain	Residue
A	ASN350
A	ARG355
A	ARG453

---

site_id	AD1
Number of Residues	2
Details	binding site for residue EDO A 1410

Chain	Residue
A	SER496
A	PRO497

---

site_id	AD2
Number of Residues	7
Details	binding site for residue PGE A 1411

Chain	Residue
A	LYS128
A	SER390
A	LYS392
A	ASP393
A	PHE414
A	HOH1536
A	HOH1686

---

site_id	AD3
Number of Residues	2
Details	binding site for residue GLY A 1412

Chain	Residue
A	ASP482
A	MET502

---

site_id	AD4
Number of Residues	2
Details	binding site for residue GLY A 1413

Chain	Residue
A	SER435
A	GLU439

---

site_id	AD5
Number of Residues	4
Details	binding site for residue EDO A 1414

Chain	Residue
A	ASP96
A	TYR177
A	ILE330
A	HOH1513

---

site_id	AD6
Number of Residues	1
Details	binding site for residue PGE A 1415

Chain	Residue
A	ASN283

---

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO A 1416

Chain	Residue
A	GLU292
A	TYR308
A	HIS519

---

site_id	AD8
Number of Residues	4
Details	binding site for residue PEG A 1417

Chain	Residue
A	GLU279
A	GLU282
A	HOH1545
B	ASN36

---

site_id	AD9
Number of Residues	1
Details	binding site for residue EDO A 1418

Chain	Residue
A	ASP427

---

site_id	AE1
Number of Residues	1
Details	binding site for residue EDO A 1419

Chain	Residue
A	PEG1401

---

site_id	AE2
Number of Residues	4
Details	binding site for residue EDO B 201

Chain	Residue
A	TYR387
A	GLN459
B	ASP122
B	HOH363

---

site_id	AE3
Number of Residues	1
Details	binding site for residue EDO B 202

Chain	Residue
B	HIS23

---

site_id	AE4
Number of Residues	2
Details	binding site for residue PEG B 203

Chain	Residue
B	GLU64
B	LYS101

---

site_id	AE5
Number of Residues	3
Details	binding site for residue DAL B 204

Chain	Residue
A	ALA85
B	ARG31
B	TYR69

---

site_id	AE6
Number of Residues	4
Details	binding site for residue EDO B 205

Chain	Residue
B	GLN26
B	ASP27
B	ASP28
B	GLU29

---

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO108-ASN125

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	141
Details	Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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