6D51
Crystal structure of L,D-transpeptidase 3 from Mycobacterium tuberculosis in complex with a faropenem-derived adduct
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue ACE A 301 |
| Chain | Residue |
| A | MET164 |
| A | TYR179 |
| A | CYS215 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 302 |
| Chain | Residue |
| A | VAL17 |
| A | ASP231 |
| A | HOH455 |
| A | HOH510 |
| A | HOH518 |
| A | HOH550 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373 |
| Chain | Residue | Details |
| A | HIS197 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373 |
| Chain | Residue | Details |
| A | CYS215 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Covalently binds to acetyl group of faropenem => ECO:0000269|PubMed:30556998, ECO:0007744|PDB:6D51 |
| Chain | Residue | Details |
| A | CYS215 |
