6D3S

Thermostabilized phosphorylated chicken CFTR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005254	molecular_function	chloride channel activity
A	0005260	molecular_function	intracellularly ATP-gated chloride channel activity
A	0005524	molecular_function	ATP binding
A	0005768	cellular_component	endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006821	biological_process	chloride transport
A	0015106	molecular_function	bicarbonate transmembrane transporter activity
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0031901	cellular_component	early endosome membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0034707	cellular_component	chloride channel complex
A	0055038	cellular_component	recycling endosome membrane
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
A	1902476	biological_process	chloride transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue ATP A 1501

Chain	Residue
A	SER170
A	TRP402
A	GLY462
A	GLY464
A	LYS465
A	THR466
A	SER467

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ATP A 1502

Chain	Residue
A	GLY1251
A	LYS1252
A	SER1253
A	THR1248
A	GLY1249

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV

Chain	Residue	Details
A	LEU549-VAL563

---