Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6D23

GLUCOSE-6-P DEHYDROGENASE (APO FORM) FROM TRYPANOSOMA CRUZI

Replaces: 4E9I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
A	0006006	biological_process	glucose metabolic process
A	0006098	biological_process	pentose-phosphate shunt
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0050661	molecular_function	NADP binding
B	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
B	0006006	biological_process	glucose metabolic process
B	0006098	biological_process	pentose-phosphate shunt
B	0016491	molecular_function	oxidoreductase activity
B	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
B	0050661	molecular_function	NADP binding
C	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
C	0006006	biological_process	glucose metabolic process
C	0006098	biological_process	pentose-phosphate shunt
C	0016491	molecular_function	oxidoreductase activity
C	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
C	0050661	molecular_function	NADP binding
D	0004345	molecular_function	glucose-6-phosphate dehydrogenase activity
D	0006006	biological_process	glucose metabolic process
D	0006098	biological_process	pentose-phosphate shunt
D	0016491	molecular_function	oxidoreductase activity
D	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
D	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 A 601

Chain	Residue
A	ARG413
A	TYR443
A	LYS445

site_id	AC2
Number of Residues	6
Details	binding site for residue SO4 A 602

Chain	Residue
A	HIS247
A	TYR248
A	LYS251
A	ARG408
A	GLN437
A	GOL611

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 603

Chain	Residue
A	MET147
A	ARG159
A	ARG163

site_id	AC4
Number of Residues	2
Details	binding site for residue SO4 A 604

Chain	Residue
A	ASP79
A	LEU80

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 605

Chain	Residue
A	LYS284
A	ARG400
A	GLU406

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 A 606

Chain	Residue
A	GLY75
A	SER77
A	GLY78
A	ALA108
A	ARG109
A	SER110
A	TYR151

site_id	AC7
Number of Residues	4
Details	binding site for residue GOL A 607

Chain	Residue
A	ARG265
A	GOL608
C	ASP390
D	GLU419

site_id	AC8
Number of Residues	4
Details	binding site for residue GOL A 608

Chain	Residue
A	ARG391
A	GOL607
A	GOL609
C	ARG391

site_id	AC9
Number of Residues	4
Details	binding site for residue GOL A 609

Chain	Residue
A	SER268
A	LYS321
A	ARG391
A	GOL608

site_id	AD1
Number of Residues	9
Details	binding site for residue GOL A 610

Chain	Residue
A	LYS251
A	GLU252
A	MET253
A	ALA436
A	GLU440
A	LEU474
A	PRO475
A	GOL611
A	HOH702

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL A 611

Chain	Residue
A	LYS251
A	ARG408
A	ASP476
A	ALA477
A	SO4602
A	GOL610

site_id	AD3
Number of Residues	1
Details	binding site for residue CL A 613

Chain	Residue
A	HIS511

site_id	AD4
Number of Residues	2
Details	binding site for residue CL A 614

Chain	Residue
A	GLU461
D	ARG469

site_id	AD5
Number of Residues	2
Details	binding site for residue CL A 615

Chain	Residue
A	THR465
A	ARG469

site_id	AD6
Number of Residues	1
Details	binding site for residue CL A 616

Chain	Residue
A	ARG421

site_id	AD7
Number of Residues	3
Details	binding site for residue SO4 B 601

Chain	Residue
B	ARG413
B	TYR443
B	LYS445

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 B 602

Chain	Residue
B	HIS247
B	TYR248
B	LYS251
B	ARG408
B	GLN437

site_id	AD9
Number of Residues	3
Details	binding site for residue SO4 B 603

Chain	Residue
B	LYS284
B	ARG400
B	GLU406

site_id	AE1
Number of Residues	2
Details	binding site for residue SO4 B 604

Chain	Residue
B	ARG159
B	ARG163

site_id	AE2
Number of Residues	7
Details	binding site for residue SO4 B 605

Chain	Residue
B	GLY75
B	SER77
B	GLY78
B	ALA108
B	ARG109
B	SER110
B	TYR151

site_id	AE3
Number of Residues	4
Details	binding site for residue SO4 B 606

Chain	Residue
B	ASP332
B	GLN336
B	ARG495
D	ARG323

site_id	AE4
Number of Residues	5
Details	binding site for residue GOL B 607

Chain	Residue
B	SER426
B	ASN455
B	ASP456
B	THR457
C	GOL609

site_id	AE5
Number of Residues	4
Details	binding site for residue GOL B 608

Chain	Residue
B	LYS251
B	GLU440
B	ASP476
B	ALA477

site_id	AE6
Number of Residues	7
Details	binding site for residue GOL B 609

Chain	Residue
B	GLN204
B	LYS205
B	GLY209
B	TRP210
B	VAL211
B	ARG240
B	GLN241

site_id	AE7
Number of Residues	1
Details	binding site for residue CL B 610

Chain	Residue
B	ARG469

site_id	AE8
Number of Residues	2
Details	binding site for residue CL B 611

Chain	Residue
B	GLN437
B	ARG408

site_id	AE9
Number of Residues	1
Details	binding site for residue CL B 612

Chain	Residue
B	ARG421

site_id	AF1
Number of Residues	1
Details	binding site for residue CL B 613

Chain	Residue
B	HIS511

site_id	AF2
Number of Residues	5
Details	binding site for residue GOL B 614

Chain	Residue
B	ARG265
B	SER268
B	ALA269
C	GLU419
D	ASP390

site_id	AF3
Number of Residues	2
Details	binding site for residue GOL B 615

Chain	Residue
B	ARG391
D	ARG391

site_id	AF4
Number of Residues	5
Details	binding site for residue GOL C 601

Chain	Residue
A	ARG323
A	GLU333
C	LYS321
C	ARG323
C	GLU333

site_id	AF5
Number of Residues	3
Details	binding site for residue GOL C 602

Chain	Residue
B	ILE330
C	PHE423
C	ASN455

site_id	AF6
Number of Residues	2
Details	binding site for residue CL C 603

Chain	Residue
B	GLU461
C	ARG469

site_id	AF7
Number of Residues	4
Details	binding site for residue SO4 C 604

Chain	Residue
C	ARG413
C	TYR443
C	LYS445
C	THR545

site_id	AF8
Number of Residues	6
Details	binding site for residue SO4 C 605

Chain	Residue
C	MET147
C	ARG159
C	ARG163
D	MET147
D	ARG159
D	ARG163

site_id	AF9
Number of Residues	7
Details	binding site for residue SO4 C 606

Chain	Residue
C	HIS247
C	TYR248
C	LYS251
C	PHE283
C	GLU285
C	GLN437
C	GOL611

site_id	AG1
Number of Residues	3
Details	binding site for residue SO4 C 607

Chain	Residue
C	LYS284
C	ARG400
C	GLN534

site_id	AG2
Number of Residues	4
Details	binding site for residue GOL C 608

Chain	Residue
C	ASN161
C	GLY201
C	ALA202
C	MET203

site_id	AG3
Number of Residues	2
Details	binding site for residue GOL C 609

Chain	Residue
B	GOL607
C	HOH716

site_id	AG4
Number of Residues	4
Details	binding site for residue GOL C 610

Chain	Residue
C	LYS251
C	GLU440
C	PRO475
C	ALA477

site_id	AG5
Number of Residues	4
Details	binding site for residue GOL C 611

Chain	Residue
C	HIS247
C	ASP304
C	HIS309
C	SO4606

site_id	AG6
Number of Residues	3
Details	binding site for residue CL C 613

Chain	Residue
C	TRP210
C	VAL211
C	GLN241

site_id	AG7
Number of Residues	2
Details	binding site for residue CL C 614

Chain	Residue
C	SER230
C	ARG244

site_id	AG8
Number of Residues	1
Details	binding site for residue CL C 615

Chain	Residue
C	HIS511

site_id	AG9
Number of Residues	3
Details	binding site for residue CL C 616

Chain	Residue
C	ASP463
C	THR465
C	ARG469

site_id	AH1
Number of Residues	2
Details	binding site for residue CL C 617

Chain	Residue
C	ARG408
C	PRO438

site_id	AH2
Number of Residues	2
Details	binding site for residue CL C 618

Chain	Residue
C	ARG339
C	ASP497

site_id	AH3
Number of Residues	2
Details	binding site for residue CL C 619

Chain	Residue
C	ASP332
C	GLN336

site_id	AH4
Number of Residues	3
Details	binding site for residue SO4 D 601

Chain	Residue
D	ARG413
D	TYR443
D	LYS445

site_id	AH5
Number of Residues	6
Details	binding site for residue SO4 D 602

Chain	Residue
D	HIS247
D	TYR248
D	LYS251
D	ARG408
D	GLN437
D	GOL612

site_id	AH6
Number of Residues	1
Details	binding site for residue SO4 D 603

Chain	Residue
D	ARG55

site_id	AH7
Number of Residues	4
Details	binding site for residue SO4 D 604

Chain	Residue
D	ASN161
D	GLY201
D	ALA202
D	MET203

site_id	AH8
Number of Residues	1
Details	binding site for residue SO4 D 605

Chain	Residue
D	GLY488

site_id	AH9
Number of Residues	5
Details	binding site for residue SO4 D 606

Chain	Residue
D	SER230
D	LYS234
D	PHE237
D	GLU239
D	ARG244

site_id	AI1
Number of Residues	6
Details	binding site for residue SO4 D 607

Chain	Residue
D	ASP332
D	VAL335
D	GLN336
D	ARG339
D	ARG495
D	HOH904

site_id	AI2
Number of Residues	3
Details	binding site for residue SO4 D 608

Chain	Residue
D	LYS284
D	ARG400
D	GLU406

site_id	AI3
Number of Residues	4
Details	binding site for residue GOL D 609

Chain	Residue
D	GLN255
D	ILE258
D	ASN492
D	GOL611

site_id	AI4
Number of Residues	3
Details	binding site for residue GOL D 610

Chain	Residue
D	TRP210
D	ARG212
D	GLN241

site_id	AI5
Number of Residues	1
Details	binding site for residue GOL D 611

Chain	Residue
D	GOL609

site_id	AI6
Number of Residues	7
Details	binding site for residue GOL D 612

Chain	Residue
D	LYS217
D	TYR248
D	PHE283
D	GLU285
D	VAL305
D	HIS309
D	SO4602

site_id	AI7
Number of Residues	2
Details	binding site for residue CL D 613

Chain	Residue
A	ARG515
D	ASP367

site_id	AI8
Number of Residues	3
Details	binding site for residue CL D 614

Chain	Residue
D	ASP463
D	THR465
D	ARG469

site_id	AI9
Number of Residues	2
Details	binding site for residue CL D 615

Chain	Residue
D	ARG408
D	PRO438

site_id	AJ1
Number of Residues	2
Details	binding site for residue CL D 616

Chain	Residue
C	ARG339
D	ARG421

site_id	AJ2
Number of Residues	1
Details	binding site for residue CL D 617

Chain	Residue
D	HIS511

Functional Information from PROSITE/UniProt

site_id	PS00069
Number of Residues	7
Details	G6P_DEHYDROGENASE Glucose-6-phosphate dehydrogenase active site. DHYLGKE

Chain	Residue	Details
A	ASP246-GLU252

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)