6CZK
Crystal structure of wild-type human pro-cathepsin H
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaCGSCWTfST |
| Chain | Residue | Details |
| A | GLN113-THR124 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. VNHAVLAVGYG |
| Chain | Residue | Details |
| A | VAL257-GLY267 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgpqWGmnGYFlI |
| Chain | Residue | Details |
| A | TYR274-ILE293 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Peptide: {"description":"Cathepsin H mini chain","featureId":"PRO_0000026207"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Propeptide: {"featureId":"PRO_0000026208","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"book","publicationDate":"1986","firstPage":"3","lastPage":"18","publisher":"Walter de Gruyter","address":"Berlin and New York","bookName":"Cysteine proteinases and their inhibitors","title":"Human cathepsins B, H and L: characterization by amino acid sequences and some kinetics of inhibition by the kininogens.","editors":["Turk V."],"authors":["Machleidt W.","Ritonja A.","Popovic T.","Kotnik M.","Brzin J.","Turk V.","Machleidt I.","Mueller-Esterl W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3342889","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3342889","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
