6CXY

Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody Fab mAb-1_19A11

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005509	molecular_function	calcium ion binding
C	0005886	cellular_component	plasma membrane
C	0007155	biological_process	cell adhesion
C	0007156	biological_process	homophilic cell-cell adhesion
C	0016020	cellular_component	membrane
C	0098609	biological_process	cell-cell adhesion

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA C 401

Chain	Residue
C	ASN102
C	ASN104
C	ASP134
C	ASP136
C	ASN143
C	ASP195

---

site_id	AC2
Number of Residues	6
Details	binding site for residue CA C 402

Chain	Residue
C	GLN101
C	ASP103
C	ASP136
C	GLU11
C	GLU69
C	ASP100

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CA C 403

Chain	Residue
C	GLU11
C	ASP67
C	GLU69
C	ASP103
C	HOH581
C	HOH698

---

site_id	AC4
Number of Residues	10
Details	binding site for residue EDO C 404

Chain	Residue
C	TRP2
C	TRP2
C	VAL3
C	VAL3
C	ILE4
C	ILE4
C	MET92
C	MET92
C	HOH518
C	HOH518

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO C 405

Chain	Residue
C	GLU13
C	GLY15
C	PRO16
C	LYS19
L	ARG99

---

site_id	AC6
Number of Residues	3
Details	binding site for residue PG4 C 406

Chain	Residue
C	ASP138
C	ASN140
C	TYR142

---

site_id	AC7
Number of Residues	7
Details	binding site for residue EDO H 301

Chain	Residue
H	THR90
H	ALA91
H	MET92
H	SER114
H	VAL115
H	THR116
H	HOH416

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO H 302

Chain	Residue
H	ARG66
H	SER84
H	GLN86
H	ASP88
H	ASP89

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO H 303

Chain	Residue
H	LYS64
H	LEU67
H	HOH424

---

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO H 304

Chain	Residue
C	VAL48
C	GLY49
C	THR63
C	GLU64
H	ARG31
H	TYR104

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO H 305

Chain	Residue
H	ASN161
H	SER162
H	ASN202
H	HOH450

---

site_id	AD3
Number of Residues	3
Details	binding site for residue EDO H 306

Chain	Residue
H	GLN111
H	GLY112
H	HOH562

---

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO H 307

Chain	Residue
H	LEU11
H	HOH431
H	HOH445

---

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO H 308

Chain	Residue
H	SER28
H	LEU29
H	SER30

---

site_id	AD6
Number of Residues	10
Details	binding site for residue EDO L 301

Chain	Residue
H	LEU45
H	GLU46
H	TRP47
H	ASN60
H	HOH511
L	THR103
L	PHE104
L	EDO306
L	HOH405
L	HOH492

---

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO L 302

Chain	Residue
L	SER71
L	GLY72
L	EDO303
L	HOH419

---

site_id	AD8
Number of Residues	6
Details	binding site for residue EDO L 303

Chain	Residue
L	SER58
L	ILE69
L	GLY70
L	EDO302
L	HOH462
L	HOH568

---

site_id	AD9
Number of Residues	5
Details	binding site for residue EDO L 304

Chain	Residue
L	LEU30
L	SER32
L	GLN35
L	HOH415
L	HOH506

---

site_id	AE1
Number of Residues	3
Details	binding site for residue EDO L 305

Chain	Residue
L	LEU30
L	HOH424
L	HOH466

---

site_id	AE2
Number of Residues	2
Details	binding site for residue EDO L 306

Chain	Residue
L	EDO301
L	PHE104

---

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO L 307

Chain	Residue
L	GLN44
L	PRO46
L	GLY47
L	GLN48

---

site_id	AE4
Number of Residues	5
Details	binding site for residue EDO L 308

Chain	Residue
L	ILE150
L	ASN151
L	VAL152
L	ASN167
L	TRP169

---

Functional Information from PROSITE/UniProt

site_id	PS00232
Number of Residues	11
Details	CADHERIN_1 Cadherin domain signature. ItVtDqNDNkP

Chain	Residue	Details
C	ILE96-PRO106

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR198-HIS204

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Cadherin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00043","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Cleavage; by S.pyogenes SpeB","evidences":[{"source":"PubMed","id":"23532847","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Man...) serine","evidences":[{"source":"UniProtKB","id":"P09803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (Man...) threonine","evidences":[{"source":"UniProtKB","id":"P09803","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---