6CUD
Structure of the human TRPC3 in a lipid-occupied, closed state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005262 | molecular_function | calcium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005262 | molecular_function | calcium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005262 | molecular_function | calcium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 508 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:29726814 |
| Chain | Residue | Details |
| A | VAL375-ALA392 | |
| B | PRO522-LEU545 | |
| B | ILE565-SER588 | |
| B | LYS629-LEU654 | |
| C | VAL375-ALA392 | |
| C | TRP424-LYS442 | |
| C | LEU456-LEU477 | |
| C | PRO522-LEU545 | |
| C | ILE565-SER588 | |
| C | LYS629-LEU654 | |
| D | VAL375-ALA392 | |
| A | TRP424-LYS442 | |
| D | TRP424-LYS442 | |
| D | LEU456-LEU477 | |
| D | PRO522-LEU545 | |
| D | ILE565-SER588 | |
| D | LYS629-LEU654 | |
| A | LEU456-LEU477 | |
| A | PRO522-LEU545 | |
| A | ILE565-SER588 | |
| A | LYS629-LEU654 | |
| B | VAL375-ALA392 | |
| B | TRP424-LYS442 | |
| B | LEU456-LEU477 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 448 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:29726814 |
| Chain | Residue | Details |
| A | SER393-THR423 | |
| D | SER393-THR423 | |
| D | ALA478-ASP521 | |
| D | TYR589-HIS628 | |
| A | ALA478-ASP521 | |
| A | TYR589-HIS628 | |
| B | SER393-THR423 | |
| B | ALA478-ASP521 | |
| B | TYR589-HIS628 | |
| C | SER393-THR423 | |
| C | ALA478-ASP521 | |
| C | TYR589-HIS628 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 120 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:29726814 |
| Chain | Residue | Details |
| A | GLU443-GLN455 | |
| A | PRO546-ASP564 | |
| B | GLU443-GLN455 | |
| B | PRO546-ASP564 | |
| C | GLU443-GLN455 | |
| C | PRO546-ASP564 | |
| D | GLU443-GLN455 | |
| D | PRO546-ASP564 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35051376, ECO:0007744|PDB:7DXB, ECO:0007744|PDB:7DXD |
| Chain | Residue | Details |
| A | GLU73 | |
| A | ASP798 | |
| B | GLU73 | |
| B | ASP798 | |
| C | GLU73 | |
| C | ASP798 | |
| D | GLU73 | |
| D | ASP798 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:35051376, ECO:0007744|PDB:7DXB |
| Chain | Residue | Details |
| A | GLU440 | |
| B | GLU786 | |
| B | GLU789 | |
| B | GLU791 | |
| C | GLU440 | |
| C | GLU443 | |
| C | ASN458 | |
| C | GLU786 | |
| C | GLU789 | |
| C | GLU791 | |
| D | GLU440 | |
| A | GLU443 | |
| D | GLU443 | |
| D | ASN458 | |
| D | GLU786 | |
| D | GLU789 | |
| D | GLU791 | |
| A | ASN458 | |
| A | GLU786 | |
| A | GLU789 | |
| A | GLU791 | |
| B | GLU440 | |
| B | GLU443 | |
| B | ASN458 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29726814, ECO:0000269|PubMed:9535843, ECO:0007744|PDB:6CUD |
| Chain | Residue | Details |
| A | ASN404 | |
| B | ASN404 | |
| C | ASN404 | |
| D | ASN404 |
