6CT0

Atomic Structure of the E2 Inner Core of Human Pyruvate Dehydrogenase Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0004742	molecular_function	dihydrolipoyllysine-residue acetyltransferase activity
0	0005515	molecular_function	protein binding
0	0005739	cellular_component	mitochondrion
0	0005759	cellular_component	mitochondrial matrix
0	0006006	biological_process	glucose metabolic process
0	0006086	biological_process	pyruvate decarboxylation to acetyl-CoA
0	0006090	biological_process	pyruvate metabolic process
0	0006099	biological_process	tricarboxylic acid cycle
0	0016407	molecular_function	acetyltransferase activity
0	0016740	molecular_function	transferase activity
0	0016746	molecular_function	acyltransferase activity
0	0034604	molecular_function	obsolete pyruvate dehydrogenase (NAD+) activity
0	0042802	molecular_function	identical protein binding
0	0042867	biological_process	pyruvate catabolic process
0	0045254	cellular_component	pyruvate dehydrogenase complex

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	12
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PalSPtMTMGTV

Chain	Residue	Details
0	PRO224-VAL235

---

site_id	PS00189
Number of Residues	30
Details	LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GdkInegDLIaeVETdKATvgFesleeCyM

Chain	Residue	Details
0	GLY116-MET145
0	GLY243-LEU272

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"Q9N0F1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P11181","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8BMF4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---