6CSF

Crystal structure of sodium/alanine symporter AgcS with D-alanine bound

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003333	biological_process	amino acid transmembrane transport
C	0005283	molecular_function	amino acid:sodium symporter activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0006865	biological_process	amino acid transport
C	0015293	molecular_function	symporter activity
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
C	1903825	biological_process	organic acid transmembrane transport
M	0003333	biological_process	amino acid transmembrane transport
M	0005283	molecular_function	amino acid:sodium symporter activity
M	0005886	cellular_component	plasma membrane
M	0006811	biological_process	monoatomic ion transport
M	0006814	biological_process	sodium ion transport
M	0006865	biological_process	amino acid transport
M	0015293	molecular_function	symporter activity
M	0016020	cellular_component	membrane
M	0055085	biological_process	transmembrane transport
M	1903825	biological_process	organic acid transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA M 501

Chain	Residue
M	THR75
M	ASN80
M	SER274
M	ASP308
M	DAL502

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site_id	AC2
Number of Residues	12
Details	binding site for residue DAL M 502

Chain	Residue
M	GLY79
M	ASN80
M	ILE165
M	GLN170
M	PHE273
M	SER274
M	GLU276
M	NA501
M	ALA74
M	THR75
M	GLY77
M	THR78

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR192-HIS198

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site_id	PS00873
Number of Residues	16
Details	NA_ALANINE_SYMP Sodium:alanine symporter family signature. GGpGAIFWMWVtAFFG

Chain	Residue	Details
M	GLY91-GLY106

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	158
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:30659158, ECO:0007744|PDB:6CSE

Chain	Residue	Details
M	MET1-PRO17
C	ASN234-ALA258
C	ALA323-MET350
C	ALA404-LEU408
M	LEU90-GLY92
M	SER180-PRO186
M	ASN234-ALA258
M	ALA323-MET350
M	ALA404-LEU408
C	MET1-PRO17
C	LEU90-GLY92
C	SER180-PRO186

---

site_id	SWS_FT_FI2
Number of Residues	448
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30659158, ECO:0007744|PDB:6CSE

Chain	Residue	Details
M	TYR18-LEU32
M	ILE387-THR403
M	VAL409-LEU430
C	TYR18-LEU32
C	LEU68-VAL89
C	PRO93-TYR111
C	ILE149-ALA179
C	LEU187-LEU202
C	SER207-MET233
C	LEU259-SER274
C	SER301-ILE322
M	LEU68-VAL89
C	GLY351-PHE378
C	ILE387-THR403
C	VAL409-LEU430
M	PRO93-TYR111
M	ILE149-ALA179
M	LEU187-LEU202
M	SER207-MET233
M	LEU259-SER274
M	SER301-ILE322
M	GLY351-PHE378

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site_id	SWS_FT_FI3
Number of Residues	254
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:30659158, ECO:0007744|PDB:6CSE

Chain	Residue	Details
M	ARG33-ALA67
C	ASN275-VAL300
C	GLU379-GLY386
C	LEU431-ALA453
M	ALA112-LYS148
M	GLY203-LYS206
M	ASN275-VAL300
M	GLU379-GLY386
M	LEU431-ALA453
C	ARG33-ALA67
C	ALA112-LYS148
C	GLY203-LYS206

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site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:30659158, ECO:0007744|PDB:6CSE

Chain	Residue	Details
M	THR75
M	GLY79
M	GLN170
C	THR75
C	GLY79
C	GLN170

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site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:30659158, ECO:0007744|PDB:6CSF

Chain	Residue	Details
M	ASN80
M	PHE273
C	ASN80
C	PHE273

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