6CSE

Crystal structure of sodium/alanine symporter AgcS with L-alanine bound

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0003333	biological_process	amino acid transmembrane transport
C	0005283	molecular_function	amino acid:sodium symporter activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006814	biological_process	sodium ion transport
C	0006865	biological_process	amino acid transport
C	0015293	molecular_function	symporter activity
C	0016020	cellular_component	membrane
C	0035725	biological_process	sodium ion transmembrane transport
C	0055085	biological_process	transmembrane transport
M	0003333	biological_process	amino acid transmembrane transport
M	0005283	molecular_function	amino acid:sodium symporter activity
M	0005886	cellular_component	plasma membrane
M	0006811	biological_process	monoatomic ion transport
M	0006814	biological_process	sodium ion transport
M	0006865	biological_process	amino acid transport
M	0015293	molecular_function	symporter activity
M	0016020	cellular_component	membrane
M	0035725	biological_process	sodium ion transmembrane transport
M	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue NA M 501

Chain	Residue
M	THR75
M	ASN80
M	SER274
M	ASP308
M	ALA502

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site_id	AC2
Number of Residues	12
Details	binding site for residue ALA M 502

Chain	Residue
M	GLY79
M	ASN80
M	ILE165
M	GLN170
M	PHE273
M	SER274
M	GLU276
M	NA501
M	ALA74
M	THR75
M	GLY77
M	THR78

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR192-HIS198

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site_id	PS00873
Number of Residues	16
Details	NA_ALANINE_SYMP Sodium:alanine symporter family signature. GGpGAIFWMWVtAFFG

Chain	Residue	Details
M	GLY91-GLY106

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	448
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30659158","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CSE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	126
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30659158","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CSE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	70
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30659158","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CSE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30659158","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CSE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30659158","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6CSF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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